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WDR74 WD repeat domain 74 [ Homo sapiens (human) ]

Gene ID: 54663, updated on 1-Jun-2020

Summary

Official Symbol
WDR74provided by HGNC
Official Full Name
WD repeat domain 74provided by HGNC
Primary source
HGNC:HGNC:25529
See related
Ensembl:ENSG00000133316 MIM:617947
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Nsa1
Expression
Ubiquitous expression in bone marrow (RPKM 9.1), ovary (RPKM 4.9) and 25 other tissues See more
Orthologs

Genomic context

See WDR74 in Genome Data Viewer
Location:
11q12.3
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (62832905..62841809, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (62600380..62608044, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene microRNA 6514 Neighboring gene nuclear RNA export factor 1 Neighboring gene syntaxin 5 Neighboring gene RNA, U6 small nuclear 118, pseudogene Neighboring gene uncharacterized LOC105369332 Neighboring gene RNA, U2 small nuclear 2, pseudogene Neighboring gene small nucleolar RNA, C/D box 22 Neighboring gene small nucleolar RNA, C/D box 31 Neighboring gene small nucleolar RNA host gene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10439, FLJ21730

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
RNA metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
blastocyst formation ISS
Inferred from Sequence or Structural Similarity
more info
 
rRNA processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
ribosomal large subunit biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribosomal large subunit biogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with nuclear exosome (RNase complex) IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IMP
Inferred from Mutant Phenotype
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
preribosome, large subunit precursor IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
WD repeat-containing protein 74
Names
NOP seven-associated protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001307977.1NP_001294906.1  WD repeat-containing protein 74 isoform 2

    See identical proteins and their annotated locations for NP_001294906.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an in-frame exon in the 3' coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AK001301, BC006351, BU740579
    Consensus CDS
    CCDS76421.1
    UniProtKB/Swiss-Prot
    Q6RFH5
    Related
    ENSP00000308931.7, ENST00000311713.11
    Conserved Domains (2) summary
    sd00039
    Location:4585
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:45302
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_001369447.1NP_001356376.1  WD repeat-containing protein 74 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AP001160
    Conserved Domains (2) summary
    sd00039
    Location:4585
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:45316
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. NM_001369448.1NP_001356377.1  WD repeat-containing protein 74 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AP001160
    Conserved Domains (2) summary
    sd00039
    Location:5290
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:7167
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  4. NM_001369449.1NP_001356378.1  WD repeat-containing protein 74 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AP001160
    Conserved Domains (2) summary
    sd00039
    Location:5290
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:7167
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  5. NM_001369450.1NP_001356379.1  WD repeat-containing protein 74 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AP001160
    Related
    ENSP00000278856.4, ENST00000278856.8
    Conserved Domains (2) summary
    sd00039
    Location:4585
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:45302
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  6. NM_001369451.1NP_001356380.1  WD repeat-containing protein 74 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AP001160
    Related
    ENSP00000432119.1, ENST00000525239.5
    Conserved Domains (2) summary
    sd00039
    Location:4585
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:45302
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  7. NM_001369453.1NP_001356382.1  WD repeat-containing protein 74 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AP001160
    Related
    ENSP00000432113.1, ENST00000525752.5
    Conserved Domains (2) summary
    sd00039
    Location:4585
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:45302
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  8. NM_018093.3NP_060563.2  WD repeat-containing protein 74 isoform 1

    See identical proteins and their annotated locations for NP_060563.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK001301, AY500828, BC006351, BU740579
    Consensus CDS
    CCDS44630.1
    UniProtKB/Swiss-Prot
    Q6RFH5
    Related
    ENSP00000435726.1, ENST00000529106.5
    Conserved Domains (2) summary
    sd00039
    Location:4585
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:45302
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. NR_161381.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP001160

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    62832905..62841809 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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