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Otud5 OTU domain containing 5 [ Mus musculus (house mouse) ]

Gene ID: 54644, updated on 8-Nov-2022

Summary

Official Symbol
Otud5provided by MGI
Official Full Name
OTU domain containing 5provided by MGI
Primary source
MGI:MGI:1859615
See related
Ensembl:ENSMUSG00000031154 AllianceGenome:MGI:1859615
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DUBA; Sfc7; DXImx46e
Summary
Predicted to enable Lys48-specific deubiquitinase activity; Lys63-specific deubiquitinase activity; and thiol-dependent deubiquitinase. Acts upstream of or within several processes, including alpha-beta T cell differentiation; negative regulation of interleukin-17 production; and regulation of T-helper 17 type immune response. Orthologous to human OTUD5 (OTU deubiquitinase 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 21.1), spleen adult (RPKM 18.3) and 28 other tissues See more
Orthologs
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Genomic context

See Otud5 in Genome Data Viewer
Location:
X A1.1; X 3.54 cM
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (7705852..7742865)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (7839613..7876626)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene GRIP1 associated protein 1 Neighboring gene microRNA 1198 Neighboring gene potassium voltage-gated channel, Shal-related family, member 1 Neighboring gene proviral integration site 2 Neighboring gene solute carrier family 35 (UDP-galactose transporter), member A2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12550

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables K48-linked deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables K63-linked deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables K63-linked deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within CD8-positive, alpha-beta T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within T-helper 17 cell lineage commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within interleukin-21 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within interleukin-9 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of interleukin-17 production IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of interleukin-17 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neural crest cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of TORC2 signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein K48-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K63-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within protein deubiquitination ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in protein deubiquitination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of T-helper 17 type immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of protein stability IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
OTU domain-containing protein 5
Names
deubiquinating enzyme A
deubiquitinating enzyme A
NP_001277465.1
NP_001277466.1
NP_613070.2
XP_006527728.1
XP_006527729.1
XP_017174053.1
XP_030107257.1
XP_030107258.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290536.1NP_001277465.1  OTU domain-containing protein 5 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL671978, AL671995
    Consensus CDS
    CCDS72336.1
    UniProtKB/TrEMBL
    A2AES5
    Related
    ENSMUSP00000111330.2, ENSMUST00000115666.8
    Conserved Domains (1) summary
    cl19932
    Location:221332
    OTU; OTU-like cysteine protease
  2. NM_001290537.1NP_001277466.1  OTU domain-containing protein 5 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame segment of the 5' coding region and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AK149777, AL671978, BY132653
    Consensus CDS
    CCDS72335.1
    UniProtKB/Swiss-Prot
    Q3U2S4
    Related
    ENSMUSP00000111332.4, ENSMUST00000115668.10
    Conserved Domains (1) summary
    cl19932
    Location:178287
    OTU; OTU-like cysteine protease
  3. NM_138604.3NP_613070.2  OTU domain-containing protein 5 isoform 2

    See identical proteins and their annotated locations for NP_613070.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AL671978, AL671995
    Consensus CDS
    CCDS29975.1
    UniProtKB/Swiss-Prot
    Q3U2S4, Q9JIG6
    Related
    ENSMUSP00000033494.10, ENSMUST00000033494.16
    Conserved Domains (1) summary
    cl19932
    Location:221332
    OTU; OTU-like cysteine protease

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    7705852..7742865
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527666.4XP_006527729.1  OTU domain-containing protein 5 isoform X4

    Conserved Domains (1) summary
    cl19932
    Location:221332
    OTU; OTU-like cysteine protease
  2. XM_006527665.5XP_006527728.1  OTU domain-containing protein 5 isoform X3

    Conserved Domains (1) summary
    cl19932
    Location:220331
    OTU; OTU-like cysteine protease
  3. XM_030251398.2XP_030107258.1  OTU domain-containing protein 5 isoform X5

    Conserved Domains (1) summary
    cl19932
    Location:177288
    OTU; OTU-like cysteine protease
  4. XM_017318564.3XP_017174053.1  OTU domain-containing protein 5 isoform X1

    UniProtKB/TrEMBL
    A2AES5
    Conserved Domains (1) summary
    cl19932
    Location:221332
    OTU; OTU-like cysteine protease
  5. XM_030251397.2XP_030107257.1  OTU domain-containing protein 5 isoform X2

    UniProtKB/Swiss-Prot
    Q9JIG6
    Related
    ENSMUSP00000111331.4, ENSMUST00000115667.10
    Conserved Domains (1) summary
    cl19932
    Location:221332
    OTU; OTU-like cysteine protease