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PPA1 inorganic pyrophosphatase 1 [ Homo sapiens (human) ]

Gene ID: 5464, updated on 2-Aug-2021

Summary

Official Symbol
PPA1provided by HGNC
Official Full Name
inorganic pyrophosphatase 1provided by HGNC
Primary source
HGNC:HGNC:9226
See related
Ensembl:ENSG00000180817 MIM:179030
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PP; PP1; IOPPP; HEL-S-66p; SID6-8061
Summary
The protein encoded by this gene is a member of the inorganic pyrophosphatase (PPase) family. PPases catalyze the hydrolysis of pyrophosphate to inorganic phosphate, which is important for the phosphate metabolism of cells. Studies of a similar protein in bovine suggested a cytoplasmic localization of this enzyme. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in adrenal (RPKM 81.3), colon (RPKM 70.8) and 25 other tissues See more
Orthologs
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Genomic context

See PPA1 in Genome Data Viewer
Location:
10q22.1
Exon count:
11
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (70202831..70233429, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (71962591..71993185, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene secretion associated Ras related GTPase 1A Neighboring gene calmodulin 2 pseudogene 2 Neighboring gene ribosomal protein S25 pseudogene 9 Neighboring gene H3K27me3-DHS negatively-acting regulatory element H2 Neighboring gene neuropeptide FF receptor 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC111556

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables inorganic diphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables magnesium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in phosphate-containing compound metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm TAS
Traceable Author Statement
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 

General protein information

Preferred Names
inorganic pyrophosphatase
Names
PPase
cytosolic inorganic pyrophosphatase
diphosphate phosphohydrolase
epididymis secretory sperm binding protein Li 66p
inorganic diphosphatase 1
pyrophosphatase (inorganic) 1
pyrophosphatase 1
pyrophosphate phospho-hydrolase
NP_066952.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021129.4NP_066952.1  inorganic pyrophosphatase

    See identical proteins and their annotated locations for NP_066952.1

    Status: REVIEWED

    Source sequence(s)
    AB026723, AL731540
    Consensus CDS
    CCDS7299.1
    UniProtKB/Swiss-Prot
    Q15181
    UniProtKB/TrEMBL
    V9HWB5
    Related
    ENSP00000362329.2, ENST00000373232.8
    Conserved Domains (1) summary
    cl00217
    Location:4241
    pyrophosphatase; Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers.

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    70202831..70233429 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_002956985.1 RNA Sequence

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