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MINDY2 MINDY lysine 48 deubiquitinase 2 [ Homo sapiens (human) ]

Gene ID: 54629, updated on 5-Aug-2022

Summary

Official Symbol
MINDY2provided by HGNC
Official Full Name
MINDY lysine 48 deubiquitinase 2provided by HGNC
Primary source
HGNC:HGNC:26954
See related
Ensembl:ENSG00000128923 MIM:618408; AllianceGenome:HGNC:26954
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM63B
Summary
Enables cysteine-type peptidase activity and polyubiquitin modification-dependent protein binding activity. Predicted to be involved in protein K48-linked deubiquitination. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 6.3), fat (RPKM 6.3) and 25 other tissues See more
Orthologs
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Genomic context

See MINDY2 in Genome Data Viewer
Location:
15q21.3-q22.1
Exon count:
10
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (58771302..58861900)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (56573291..56663918)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (59063501..59154099)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, C/D box 3 pseudogene 1 Neighboring gene MINDY2 divergent transcript Neighboring gene zinc finger protein 444 pseudogene 1 Neighboring gene ribosomal protein L21 pseudogene 14

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1164

General protein information

Preferred Names
ubiquitin carboxyl-terminal hydrolase MINDY-2
Names
MINDY deubiquitinase 2
deubiquitinating enzyme MINDY-2
family with sequence similarity 63 member B
protein FAM63B
NP_001035540.1
NP_001035543.1
XP_011519989.1
XP_011519990.1
XP_011519991.1
XP_011519992.1
XP_016877821.1
XP_016877822.1
XP_016877823.1
XP_016877824.1
XP_024305732.1
XP_047288655.1
XP_047288656.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040450.3NP_001035540.1  ubiquitin carboxyl-terminal hydrolase MINDY-2 isoform a

    See identical proteins and their annotated locations for NP_001035540.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC090515, AK075319, CB321913
    Consensus CDS
    CCDS42046.1
    UniProtKB/Swiss-Prot
    Q8NBR6, Q9ULQ6
    Related
    ENSP00000452885.1, ENST00000559228.6
    Conserved Domains (1) summary
    pfam04424
    Location:279390
    DUF544; Protein of unknown function (DUF544)
  2. NM_001040453.3NP_001035543.1  ubiquitin carboxyl-terminal hydrolase MINDY-2 isoform b

    See identical proteins and their annotated locations for NP_001035543.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the terminal coding exon, compared to variant 1, and encodes a shorter isoform (b), compared to isoform a.
    Source sequence(s)
    AC090515, BC144616, CB321913
    Consensus CDS
    CCDS45268.1
    UniProtKB/Swiss-Prot
    Q8NBR6
    Related
    ENSP00000393231.2, ENST00000450403.3
    Conserved Domains (1) summary
    pfam04424
    Location:279390
    DUF544; Protein of unknown function (DUF544)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    58771302..58861900
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521687.3XP_011519989.1  ubiquitin carboxyl-terminal hydrolase MINDY-2 isoform X1

    Conserved Domains (1) summary
    pfam04424
    Location:279408
    DUF544; Protein of unknown function (DUF544)
  2. XM_011521688.3XP_011519990.1  ubiquitin carboxyl-terminal hydrolase MINDY-2 isoform X2

    Conserved Domains (1) summary
    pfam04424
    Location:279408
    DUF544; Protein of unknown function (DUF544)
  3. XM_017022332.3XP_016877821.1  ubiquitin carboxyl-terminal hydrolase MINDY-2 isoform X7

  4. XM_047432700.1XP_047288656.1  ubiquitin carboxyl-terminal hydrolase MINDY-2 isoform X8

  5. XM_011521689.3XP_011519991.1  ubiquitin carboxyl-terminal hydrolase MINDY-2 isoform X3

    Conserved Domains (1) summary
    pfam04424
    Location:279374
    DUF544; Protein of unknown function (DUF544)
  6. XM_047432699.1XP_047288655.1  ubiquitin carboxyl-terminal hydrolase MINDY-2 isoform X4

  7. XM_017022333.3XP_016877822.1  ubiquitin carboxyl-terminal hydrolase MINDY-2 isoform X9

    Conserved Domains (1) summary
    PRK07003
    Location:19209
    PRK07003; DNA polymerase III subunit gamma/tau
  8. XM_017022334.3XP_016877823.1  ubiquitin carboxyl-terminal hydrolase MINDY-2 isoform X10

  9. XM_011521690.3XP_011519992.1  ubiquitin carboxyl-terminal hydrolase MINDY-2 isoform X5

    Conserved Domains (1) summary
    pfam04424
    Location:279356
    DUF544; Protein of unknown function (DUF544)
  10. XM_024449964.2XP_024305732.1  ubiquitin carboxyl-terminal hydrolase MINDY-2 isoform X6

    Conserved Domains (2) summary
    pfam04424
    Location:279356
    DUF544; Protein of unknown function (DUF544)
    cl26386
    Location:19209
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  11. XM_017022335.3XP_016877824.1  ubiquitin carboxyl-terminal hydrolase MINDY-2 isoform X11

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    56573291..56663918
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_019092.1: Suppressed sequence

    Description
    NM_019092.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.