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HES2 hes family bHLH transcription factor 2 [ Homo sapiens (human) ]

Gene ID: 54626, updated on 22-Apr-2017
Official Symbol
HES2provided by HGNC
Official Full Name
hes family bHLH transcription factor 2provided by HGNC
Primary source
HGNC:HGNC:16005
See related
Ensembl:ENSG00000069812 MIM:609970; Vega:OTTHUMG00000000752
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
bHLHb40
Orthologs
Location:
1p36.31
Exon count:
4
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 1 NC_000001.11 (6415232..6419919, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (6475292..6484724, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 153 Neighboring gene acyl-CoA thioesterase 7 Neighboring gene microRNA 4252 Neighboring gene espin Neighboring gene TNF receptor superfamily member 25 Neighboring gene pleckstrin homology and RhoGEF domain containing G5

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
negative regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
transcription factor HES-2
Names
class B basic helix-loop-helix protein 40
hairy and enhancer of split 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019089.4NP_061962.2  transcription factor HES-2

    See identical proteins and their annotated locations for NP_061962.2

    Status: VALIDATED

    Source sequence(s)
    AK023754, AK091122, BU729177
    Consensus CDS
    CCDS30574.1
    UniProtKB/Swiss-Prot
    Q9Y543
    Related
    ENSP00000367065.4, OTTHUMP00000000825, ENST00000377834.8, OTTHUMT00000001881
    Conserved Domains (2) summary
    smart00511
    Location:84127
    ORANGE; Orange domain
    cd00083
    Location:1270
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p7 Primary Assembly

    Range
    6415232..6419919 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 Alternate CHM1_1.1

    Range
    6463852..6468539 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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