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PARP14 poly(ADP-ribose) polymerase family member 14 [ Homo sapiens (human) ]

Gene ID: 54625, updated on 21-Dec-2019

Summary

Official Symbol
PARP14provided by HGNC
Official Full Name
poly(ADP-ribose) polymerase family member 14provided by HGNC
Primary source
HGNC:HGNC:29232
See related
Ensembl:ENSG00000173193 MIM:610028
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BAL2; ARTD8; pART8; PARP-14
Summary
This gene encodes a member of the poly(ADP-ribose) polymerase (PARP) protein family. The encoded anti-apoptotic protein may regulate aerobic glycolysis and promote survival of cancer cells. Increased expression of this gene has been reported in a variety of tumor types. [provided by RefSeq, Jul 2016]
Expression
Ubiquitous expression in spleen (RPKM 17.4), appendix (RPKM 15.1) and 24 other tissues See more
Orthologs

Genomic context

See PARP14 in Genome Data Viewer
Location:
3q21.1
Exon count:
17
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (122680726..122730840)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (122399672..122449687)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene poly(ADP-ribose) polymerase family member 14 pseudogene Neighboring gene poly(ADP-ribose) polymerase family member 15 Neighboring gene eukaryotic translation initiation factor 4B pseudogene 8 Neighboring gene HSPB1 associated protein 1 Neighboring gene solute carrier family 49 member 4 Neighboring gene long intergenic non-protein coding RNA 2035

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1268

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NAD+ ADP-ribosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein ADP-ribosylase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
membrane HDA PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
protein mono-ADP-ribosyltransferase PARP14
Names
ADP-ribosyltransferase diphtheria toxin-like 8
B-aggressive lymphoma 2
b aggressive lymphoma protein 2
collaborator of STAT6
poly [ADP-ribose] polymerase 14
NP_060024.2
XP_011511230.1
XP_011511231.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051076.1 RefSeqGene

    Range
    5100..55115
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_017554.3NP_060024.2  protein mono-ADP-ribosyltransferase PARP14

    See identical proteins and their annotated locations for NP_060024.2

    Status: REVIEWED

    Source sequence(s)
    AC048348, AC092908
    Consensus CDS
    CCDS46894.1
    UniProtKB/Swiss-Prot
    Q460N5
    UniProtKB/TrEMBL
    Q8N546
    Related
    ENSP00000418194.2, ENST00000474629.7
    Conserved Domains (8) summary
    COG2110
    Location:808981
    YmdB; O-acetyl-ADP-ribose deacetylase (regulator of RNase III), contains Macro domain [Translation, ribosomal structure and biogenesis]
    cd01439
    Location:16791799
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
    cd02903
    Location:10141155
    Macro_BAL_like; Macro domain, BAL_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). ...
    cd02907
    Location:801977
    Macro_Af1521_BAL_like; Macro domain, Af1521- and BAL-like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose ...
    cd12300
    Location:688
    RRM1_PAR14; RNA recognition motif 1 in vertebrate poly [ADP-ribose] polymerase 14 (PARP-14)
    cd12543
    Location:227301
    RRM2_PAR14; RNA recognition motif 2 in vertebrate poly [ADP-ribose] polymerase 14 (PARP-14)
    pfam00644
    Location:16181800
    PARP; Poly(ADP-ribose) polymerase catalytic domain
    cl02729
    Location:15371597
    WWE; WWE domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    122680726..122730840
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011512929.2XP_011511231.1  protein mono-ADP-ribosyltransferase PARP14 isoform X2

    Conserved Domains (5) summary
    COG2110
    Location:808981
    YmdB; O-acetyl-ADP-ribose deacetylase (regulator of RNase III), contains Macro domain [Translation, ribosomal structure and biogenesis]
    cd02903
    Location:10141155
    Macro_BAL_like; Macro domain, BAL_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). ...
    cd02907
    Location:801977
    Macro_Af1521_BAL_like; Macro domain, Af1521- and BAL-like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose ...
    cd12300
    Location:688
    RRM1_PAR14; RNA recognition motif 1 in vertebrate poly [ADP-ribose] polymerase 14 (PARP-14)
    cd12543
    Location:227301
    RRM2_PAR14; RNA recognition motif 2 in vertebrate poly [ADP-ribose] polymerase 14 (PARP-14)
  2. XM_011512928.3XP_011511230.1  protein mono-ADP-ribosyltransferase PARP14 isoform X1

    Conserved Domains (6) summary
    COG2110
    Location:808981
    YmdB; O-acetyl-ADP-ribose deacetylase (regulator of RNase III), contains Macro domain [Translation, ribosomal structure and biogenesis]
    cd02903
    Location:10141155
    Macro_BAL_like; Macro domain, BAL_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). ...
    cd02907
    Location:801977
    Macro_Af1521_BAL_like; Macro domain, Af1521- and BAL-like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose ...
    cd12300
    Location:688
    RRM1_PAR14; RNA recognition motif 1 in vertebrate poly [ADP-ribose] polymerase 14 (PARP-14)
    cd12543
    Location:227301
    RRM2_PAR14; RNA recognition motif 2 in vertebrate poly [ADP-ribose] polymerase 14 (PARP-14)
    cl02729
    Location:15371597
    WWE; WWE domain

RNA

  1. XR_002959544.1 RNA Sequence

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