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VSIG10 V-set and immunoglobulin domain containing 10 [ Homo sapiens (human) ]

Gene ID: 54621, updated on 22-Sep-2022

Summary

Official Symbol
VSIG10provided by HGNC
Official Full Name
V-set and immunoglobulin domain containing 10provided by HGNC
Primary source
HGNC:HGNC:26078
See related
Ensembl:ENSG00000176834 AllianceGenome:HGNC:26078
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable cell adhesion molecule binding activity. Predicted to be involved in cell-cell adhesion. Predicted to be active in cell-cell junction. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in small intestine (RPKM 12.6), colon (RPKM 8.8) and 24 other tissues See more
Orthologs
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Genomic context

See VSIG10 in Genome Data Viewer
Location:
12q24.23
Exon count:
10
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (118063593..118104011, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (118050893..118091265, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (118501398..118541816, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene kinase suppressor of ras 2 Neighboring gene uncharacterized LOC105370011 Neighboring gene uncharacterized LOC124903030 Neighboring gene replication factor C subunit 5 Neighboring gene uncharacterized LOC124903029 Neighboring gene WD repeat and SOCS box containing 2 Neighboring gene uncharacterized LOC101928274 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancers GRCh37_chr12:118557876-118558588 and GRCh37_chr12:118558589-118559300 Neighboring gene Sharpr-MPRA regulatory region 10186

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog
TAOK3, a novel genome-wide association study locus associated with morphine requirement and postoperative pain in a retrospective pediatric day surgery population.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC1013, FLJ20674

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cell adhesion molecule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cell-cell junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
V-set and immunoglobulin domain-containing protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019086.6NP_061959.2  V-set and immunoglobulin domain-containing protein 10 precursor

    See identical proteins and their annotated locations for NP_061959.2

    Status: VALIDATED

    Source sequence(s)
    AC026366, AC131238, BC034471, DA995625
    Consensus CDS
    CCDS44992.1
    UniProtKB/Swiss-Prot
    Q8N0Z9, Q9NWQ7
    Related
    ENSP00000352172.5, ENST00000359236.10
    Conserved Domains (4) summary
    cd00096
    Location:327402
    Ig; Immunoglobulin domain
    smart00410
    Location:31119
    IG_like; Immunoglobulin like
    pfam00047
    Location:136208
    ig; Immunoglobulin domain
    pfam07686
    Location:29119
    V-set; Immunoglobulin V-set domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    118063593..118104011 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006719467.3XP_006719530.1  V-set and immunoglobulin domain-containing protein 10 isoform X3

    Conserved Domains (3) summary
    cd00096
    Location:226301
    Ig; Immunoglobulin domain
    smart00410
    Location:31119
    IG_like; Immunoglobulin like
    pfam07686
    Location:29119
    V-set; Immunoglobulin V-set domain
  2. XM_011538502.2XP_011536804.1  V-set and immunoglobulin domain-containing protein 10 isoform X1

    Conserved Domains (4) summary
    cd00096
    Location:327402
    Ig; Immunoglobulin domain
    smart00410
    Location:31119
    IG_like; Immunoglobulin like
    pfam00047
    Location:136208
    ig; Immunoglobulin domain
    pfam07686
    Location:29119
    V-set; Immunoglobulin V-set domain
  3. XM_005253908.5XP_005253965.1  V-set and immunoglobulin domain-containing protein 10 isoform X4

    Conserved Domains (2) summary
    cd00096
    Location:155230
    Ig; Immunoglobulin domain
    smart00410
    Location:152233
    IG_like; Immunoglobulin like
  4. XM_006719468.2XP_006719531.1  V-set and immunoglobulin domain-containing protein 10 isoform X5

    Conserved Domains (2) summary
    cd00096
    Location:94169
    Ig; Immunoglobulin domain
    smart00410
    Location:91172
    IG_like; Immunoglobulin like
  5. XM_047429032.1XP_047284988.1  V-set and immunoglobulin domain-containing protein 10 isoform X2

RNA

  1. XR_002957343.2 RNA Sequence

  2. XR_002957342.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    118050893..118091265 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)