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Ubtfl1 upstream binding transcription factor, RNA polymerase I-like 1 [ Mus musculus (house mouse) ]

Gene ID: 546118, updated on 5-Mar-2024

Summary

Official Symbol
Ubtfl1provided by MGI
Official Full Name
upstream binding transcription factor, RNA polymerase I-like 1provided by MGI
Primary source
MGI:MGI:3588290
See related
Ensembl:ENSMUSG00000074502 AllianceGenome:MGI:3588290
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hmgpi; B020006M18Rik
Summary
Predicted to enable DNA binding activity. Acts upstream of or within blastocyst growth; embryo implantation; and regulation of gene expression. Located in cytoplasm and nucleus. Is expressed in 4-cell stage embryo; 8-cell stage embryo; blastocyst; compacted morula; and early conceptus. Orthologous to several human genes including UBTFL1 (upstream binding transcription factor like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See Ubtfl1 in Genome Data Viewer
Location:
9 A2; 9 7.04 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (18315714..18322798)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (18404418..18411502)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene N-acetylated alpha-linked acidic dipeptidase 2 Neighboring gene STARR-seq mESC enhancer starr_23417 Neighboring gene upstream binding transcription factor, RNA polymerase I-like 1 pseudogene Neighboring gene microtubule-associated protein 1 light chain 3 pseudogene Neighboring gene methyl-CpG binding domain protein 3-like 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase I core promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase I general transcription initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables molecular_function ND
No biological Data available
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
upstream-binding factor 1-like protein 1
Names
HMG-box preimplantation embryo-specific protein
HMG-box protein, preimplantation-embryo-specific

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033793.3NP_001028965.1  upstream-binding factor 1-like protein 1

    See identical proteins and their annotated locations for NP_001028965.1

    Status: VALIDATED

    Source sequence(s)
    AK139937, AK163257, BB289342
    Consensus CDS
    CCDS40540.1
    UniProtKB/Swiss-Prot
    Q3TQX0, Q3USZ2
    Related
    ENSMUSP00000129611.2, ENSMUST00000164441.2
    Conserved Domains (1) summary
    cd01390
    Location:101166
    HMGB-UBF_HMG-box; HMGB-UBF_HMG-box, class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone ...
  2. NM_001360216.1NP_001347145.1  upstream-binding factor 1-like protein 1

    Status: VALIDATED

    Source sequence(s)
    AC162941
    Consensus CDS
    CCDS40540.1
    UniProtKB/Swiss-Prot
    Q3TQX0, Q3USZ2
    Related
    ENSMUSP00000126540.2, ENSMUST00000169398.3
    Conserved Domains (1) summary
    cd01390
    Location:101166
    HMGB-UBF_HMG-box; HMGB-UBF_HMG-box, class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    18315714..18322798
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)