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Pde3a phosphodiesterase 3A, cGMP inhibited [ Mus musculus (house mouse) ]

Gene ID: 54611, updated on 9-Apr-2019

Summary

Official Symbol
Pde3aprovided by MGI
Official Full Name
phosphodiesterase 3A, cGMP inhibitedprovided by MGI
Primary source
MGI:MGI:1860764
See related
Ensembl:ENSMUSG00000041741
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C87899; A930022O17Rik
Expression
Broad expression in lung adult (RPKM 3.5), heart adult (RPKM 3.3) and 24 other tissues See more
Orthologs

Genomic context

See Pde3a in Genome Data Viewer
Location:
6; 6 G2
Exon count:
18
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (141249269..141506862)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (141197790..141447872)

Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 30524 Neighboring gene ribosomal protein L11 pseudogene Neighboring gene predicted gene 28523 Neighboring gene predicted gene 10400 Neighboring gene solute carrier organic anion transporter family, member 1c1 Neighboring gene solute carrier organic anion transporter family, member 1b2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
3',5'-cyclic-AMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
3',5'-cyclic-AMP phosphodiesterase activity IDA
Inferred from Direct Assay
more info
PubMed 
3',5'-cyclic-nucleotide phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cAMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
cGMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cGMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
cellular response to cGMP ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of cAMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
negative regulation of vascular permeability ISO
Inferred from Sequence Orthology
more info
 
oocyte maturation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oocyte maturation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of oocyte development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of oocyte development IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of vascular permeability ISO
Inferred from Sequence Orthology
more info
 
regulation of meiotic nuclear division IDA
Inferred from Direct Assay
more info
PubMed 
response to drug IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cGMP-inhibited 3',5'-cyclic phosphodiesterase A
Names
CGI-PDE A
cGMP-inhibited phosphodiesterase
cyclic GMP-inhibited phosphodiesterase A
NP_061249.1
XP_006507042.1
XP_011239897.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018779.2NP_061249.1  cGMP-inhibited 3',5'-cyclic phosphodiesterase A

    See identical proteins and their annotated locations for NP_061249.1

    Status: VALIDATED

    Source sequence(s)
    AC155835, AF099187
    Consensus CDS
    CCDS20676.1
    UniProtKB/Swiss-Prot
    Q9Z0X4
    UniProtKB/TrEMBL
    B2RR84
    Related
    ENSMUSP00000038749.7, ENSMUST00000043259.9
    Conserved Domains (1) summary
    pfam00233
    Location:7511012
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

    Range
    141249269..141506862
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506979.3XP_006507042.1  cGMP-inhibited 3',5'-cyclic phosphodiesterase A isoform X2

    Conserved Domains (1) summary
    pfam00233
    Location:451712
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  2. XM_011241595.2XP_011239897.1  cGMP-inhibited 3',5'-cyclic phosphodiesterase A isoform X1

    Conserved Domains (1) summary
    pfam00233
    Location:456717
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
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