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Pde3a phosphodiesterase 3A, cGMP inhibited [ Mus musculus (house mouse) ]

Gene ID: 54611, updated on 7-May-2024

Summary

Official Symbol
Pde3aprovided by MGI
Official Full Name
phosphodiesterase 3A, cGMP inhibitedprovided by MGI
Primary source
MGI:MGI:1860764
See related
Ensembl:ENSMUSG00000041741 AllianceGenome:MGI:1860764
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A930022O17Rik
Summary
Enables 3',5'-cyclic-AMP phosphodiesterase activity. Acts upstream of or within several processes, including oocyte maturation; positive regulation of oocyte development; and regulation of meiotic nuclear division. Located in cytosol and membrane. Is expressed in several structures, including alimentary system; central nervous system; cranium; genitourinary system; and integumental system. Human ortholog(s) of this gene implicated in hypertension and brachydactyly syndrome. Orthologous to human PDE3A (phosphodiesterase 3A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 3.5), heart adult (RPKM 3.3) and 24 other tissues See more
Orthologs
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Genomic context

See Pde3a in Genome Data Viewer
Location:
6 G2; 6 71.87 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (141194995..141452588)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (141249269..141506862)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30215 Neighboring gene ribosomal protein L38, pseudogene 2 Neighboring gene STARR-positive B cell enhancer mm9_chr6:140765370-140765671 Neighboring gene STARR-seq mESC enhancer starr_17681 Neighboring gene STARR-seq mESC enhancer starr_17683 Neighboring gene STARR-seq mESC enhancer starr_17684 Neighboring gene predicted gene, 30524 Neighboring gene ribosomal protein L11 pseudogene Neighboring gene predicted gene 28523 Neighboring gene STARR-seq mESC enhancer starr_17687 Neighboring gene STARR-seq mESC enhancer starr_17688 Neighboring gene STARR-seq mESC enhancer starr_17689 Neighboring gene STARR-seq mESC enhancer starr_17690 Neighboring gene predicted gene 10400 Neighboring gene STARR-seq mESC enhancer starr_17691 Neighboring gene 40S ribosomal protein S25 pseudogene Neighboring gene solute carrier organic anion transporter family, member 1c1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables 3',5'-cyclic-AMP phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
 
enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables 3',5'-cyclic-GMP phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
 
enables 3',5'-cyclic-nucleotide phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
 
enables cGMP-inhibited cyclic-nucleotide phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
 
enables estrogen binding ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclear estrogen receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cAMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in cGMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to cGMP ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cAMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of vascular permeability ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of oocyte development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within oocyte maturation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of oocyte development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of vascular permeability ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of meiotic nuclear division IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of ribonuclease activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to xenobiotic stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
Names
CGI-PDE A
cGMP-inhibited 3',5'-cyclic phosphodiesterase A
cGMP-inhibited phosphodiesterase
cyclic GMP-inhibited phosphodiesterase A
NP_061249.1
XP_006507042.1
XP_011239897.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018779.2NP_061249.1  cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A

    See identical proteins and their annotated locations for NP_061249.1

    Status: VALIDATED

    Source sequence(s)
    AC155835, AF099187
    Consensus CDS
    CCDS20676.1
    UniProtKB/Swiss-Prot
    Q9Z0X4
    UniProtKB/TrEMBL
    B2RR84
    Related
    ENSMUSP00000038749.8, ENSMUST00000043259.10
    Conserved Domains (1) summary
    pfam00233
    Location:7511012
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    141194995..141452588
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506979.5XP_006507042.1  cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A isoform X2

    Conserved Domains (1) summary
    pfam00233
    Location:451712
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  2. XM_011241595.4XP_011239897.1  cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A isoform X1

    Conserved Domains (1) summary
    pfam00233
    Location:456717
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase