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Ubqln2 ubiquilin 2 [ Mus musculus (house mouse) ]

Gene ID: 54609, updated on 11-Apr-2024

Summary

Official Symbol
Ubqln2provided by MGI
Official Full Name
ubiquilin 2provided by MGI
Primary source
MGI:MGI:1860283
See related
Ensembl:ENSMUSG00000050148 AllianceGenome:MGI:1860283
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dsk2; Chap1; Plic2; Plic-2; HRIHFB2157
Summary
Predicted to enable identical protein binding activity and polyubiquitin modification-dependent protein binding activity. Predicted to be involved in several processes, including negative regulation of receptor-mediated endocytosis; regulation of cellular catabolic process; and ubiquitin-dependent ERAD pathway. Predicted to act upstream of or within autophagy. Predicted to be located in cytoplasm and plasma membrane. Predicted to be active in cytosol. Is expressed in telencephalon. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis and amyotrophic lateral sclerosis type 15. Orthologous to human UBQLN2 (ubiquilin 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See Ubqln2 in Genome Data Viewer
Location:
X F3; X 68.46 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (152281228..152284558)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (153498232..153501562)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_48116 Neighboring gene Kruppel-like transcription factor 8 Neighboring gene STARR-seq mESC enhancer starr_48117 Neighboring gene STARR-seq mESC enhancer starr_48118 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_48121 Neighboring gene predicted gene, 39543 Neighboring gene cysteine-rich perinuclear theca 3 Neighboring gene predicted gene, 25793

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables molecular condensate scaffold activity ISO
Inferred from Sequence Orthology
more info
 
enables polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in ERAD pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within autophagy IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of G protein-coupled receptor internalization ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of clathrin-dependent endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ERAD pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of autophagosome assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of macroautophagy IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of macroautophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ubiquilin-2
Names
Ubiquitin-related protein
protein linking IAP with cytoskeleton 2
ubiquitin-like product Chap1/Dsk2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018798.2NP_061268.2  ubiquilin-2

    See identical proteins and their annotated locations for NP_061268.2

    Status: VALIDATED

    Source sequence(s)
    BC053022
    Consensus CDS
    CCDS30482.1
    UniProtKB/Swiss-Prot
    B1AY62, Q7TSJ8, Q8VDH9, Q9QZM0
    Related
    ENSMUSP00000056888.9, ENSMUST00000060714.10
    Conserved Domains (4) summary
    smart00727
    Location:396440
    STI1; Heat shock chaperonin-binding motif
    cd01808
    Location:33103
    hPLIC_N; Ubiquitin-like domain of hPLIC-1 and hPLIC2
    smart00213
    Location:33103
    UBQ; Ubiquitin homologues
    cd14399
    Location:595634
    UBA_PLICs; UBA domain of eukaryotic protein linking integrin-associated protein (IAP, also known as CD47) with cytoskeleton (PLIC) proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    152281228..152284558
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)