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Mast3 microtubule associated serine/threonine kinase 3 [ Mus musculus (house mouse) ]

Gene ID: 546071, updated on 11-Apr-2024

Summary

Official Symbol
Mast3provided by MGI
Official Full Name
microtubule associated serine/threonine kinase 3provided by MGI
Primary source
MGI:MGI:2683541
See related
Ensembl:ENSMUSG00000031833 AllianceGenome:MGI:2683541
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0561
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in cytoskeleton organization; intracellular signal transduction; and peptidyl-serine phosphorylation. Predicted to act upstream of or within phosphorylation. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human MAST3 (microtubule associated serine/threonine kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 51.9), cortex adult (RPKM 30.0) and 25 other tissues See more
Orthologs
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Genomic context

Location:
8 B3.3; 8 34.15 cM
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (71230761..71257681, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (70778117..70805048, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10506 Neighboring gene phosphoinositide-3-kinase regulatory subunit 2 Neighboring gene RIKEN cDNA 2010320M18 gene Neighboring gene STARR-positive B cell enhancer ABC_E8241 Neighboring gene STARR-positive B cell enhancer ABC_E6649 Neighboring gene STARR-positive B cell enhancer ABC_E2265 Neighboring gene microRNA 7240 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:73330531-73330714 Neighboring gene interleukin 12 receptor, beta 1 Neighboring gene STARR-positive B cell enhancer ABC_E133 Neighboring gene arrestin domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
microtubule-associated serine/threonine-protein kinase 3
NP_001389902.1
NP_001389903.1
NP_001389904.1
NP_001389905.1
NP_001389907.1
NP_001389908.1
NP_001389909.1
NP_955012.2
XP_006509771.2
XP_006509772.2
XP_006509773.2
XP_006509775.1
XP_017168397.2
XP_017168398.1
XP_036010079.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001402973.1NP_001389902.1  microtubule-associated serine/threonine-protein kinase 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC162446
  2. NM_001402974.1NP_001389903.1  microtubule-associated serine/threonine-protein kinase 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC162446
    UniProtKB/Swiss-Prot
    E9QQ28, Q3U214, Q6A047
    Related
    ENSMUSP00000128703.3, ENSMUST00000166004.3
  3. NM_001402975.1NP_001389904.1  microtubule-associated serine/threonine-protein kinase 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC162446
  4. NM_001402976.1NP_001389905.1  microtubule-associated serine/threonine-protein kinase 3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC162446
  5. NM_001402978.1NP_001389907.1  microtubule-associated serine/threonine-protein kinase 3 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC162446
  6. NM_001402979.1NP_001389908.1  microtubule-associated serine/threonine-protein kinase 3 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC162446
  7. NM_001402980.1NP_001389909.1  microtubule-associated serine/threonine-protein kinase 3 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC162446
  8. NM_199308.3NP_955012.2  microtubule-associated serine/threonine-protein kinase 3 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC162446
    Consensus CDS
    CCDS52577.1
    UniProtKB/TrEMBL
    A0A1D5RM97
    Related
    ENSMUSP00000148686.2, ENSMUST00000211948.2
    Conserved Domains (4) summary
    smart00220
    Location:373646
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:9551032
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:372651
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:64337
    DUF1908; Domain of unknown function (DUF1908)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    71230761..71257681 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154186.1XP_036010079.1  microtubule-associated serine/threonine-protein kinase 3 isoform X11

    Conserved Domains (3) summary
    cd00992
    Location:9551032
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:372651
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:57337
    DUF1908; Domain of unknown function (DUF1908)
  2. XM_017312908.2XP_017168397.2  microtubule-associated serine/threonine-protein kinase 3 isoform X10

    Conserved Domains (3) summary
    cd00992
    Location:9561033
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:373652
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:58338
    DUF1908; Domain of unknown function (DUF1908)
  3. XM_006509710.3XP_006509773.2  microtubule-associated serine/threonine-protein kinase 3 isoform X5

    Conserved Domains (3) summary
    cd00992
    Location:9781055
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:395674
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:87360
    DUF1908; Domain of unknown function (DUF1908)
  4. XM_006509708.3XP_006509771.2  microtubule-associated serine/threonine-protein kinase 3 isoform X2

    Conserved Domains (3) summary
    cd00992
    Location:9851062
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:402681
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:87367
    DUF1908; Domain of unknown function (DUF1908)
  5. XM_006509709.4XP_006509772.2  microtubule-associated serine/threonine-protein kinase 3 isoform X3

    Conserved Domains (3) summary
    cd00992
    Location:9791056
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:396675
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:88361
    DUF1908; Domain of unknown function (DUF1908)
  6. XM_017312909.2XP_017168398.1  microtubule-associated serine/threonine-protein kinase 3 isoform X4

    Conserved Domains (3) summary
    smart00228
    Location:9741055
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd05609
    Location:395674
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:80360
    DUF1908; Domain of unknown function (DUF1908)
  7. XM_006509712.5XP_006509775.1  microtubule-associated serine/threonine-protein kinase 3 isoform X9

    Conserved Domains (3) summary
    cd00992
    Location:9611038
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:378657
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:63343
    DUF1908; Domain of unknown function (DUF1908)