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Calcrl calcitonin receptor-like [ Mus musculus (house mouse) ]

Gene ID: 54598, updated on 22-Sep-2022

Summary

Official Symbol
Calcrlprovided by MGI
Official Full Name
calcitonin receptor-likeprovided by MGI
Primary source
MGI:MGI:1926944
See related
Ensembl:ENSMUSG00000059588 AllianceGenome:MGI:1926944
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CRLR
Summary
Enables calcitonin gene-related peptide receptor activity. Acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway; heart development; and positive regulation of smooth muscle cell proliferation. Predicted to be located in endoplasmic reticulum; endosome; and lysosome. Predicted to be part of CGRP receptor complex and adrenomedullin receptor complex. Predicted to be active in plasma membrane. Is expressed in dorsal root ganglion and lung epithelium. Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human CALCRL (calcitonin receptor like receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in lung adult (RPKM 53.6), bladder adult (RPKM 7.2) and 3 other tissues See more
Orthologs
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Genomic context

See Calcrl in Genome Data Viewer
Location:
2; 2 D
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (84160970..84255786, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (84330626..84425405, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (84170783..84265423, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L6 pseudogene Neighboring gene predicted gene, 54167 Neighboring gene tissue factor pathway inhibitor Neighboring gene predicted gene 13710

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables adrenomedullin binding ISO
Inferred from Sequence Orthology
more info
 
enables adrenomedullin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables adrenomedullin receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables calcitonin gene-related peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcitonin gene-related peptide receptor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables calcitonin gene-related peptide receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables calcitonin receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in adrenomedullin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in calcitonin gene-related peptide receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to sucrose stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of vascular associated smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein transport ISO
Inferred from Sequence Orthology
more info
 
involved_in receptor internalization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of vascular associated smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of CGRP receptor complex ISO
Inferred from Sequence Orthology
more info
 
part_of adrenomedullin receptor complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
calcitonin gene-related peptide type 1 receptor
Names
CGRP type 1 receptor
calcitonin receptor-like receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018782.2NP_061252.2  calcitonin gene-related peptide type 1 receptor precursor

    See identical proteins and their annotated locations for NP_061252.2

    Status: VALIDATED

    Source sequence(s)
    AF146525, AF209905, AK137210, CB595628, DY245973
    Consensus CDS
    CCDS16184.1
    UniProtKB/Swiss-Prot
    Q9R1W5, Q9WUP2
    UniProtKB/TrEMBL
    A2AR99
    Related
    ENSMUSP00000073875.3, ENSMUST00000074262.9
    Conserved Domains (2) summary
    cd15274
    Location:137410
    7tmB1_calcitonin_R; calcitonin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors
    pfam02793
    Location:61128
    HRM; Hormone receptor domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    84160970..84255786 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499918.5XP_006499981.1  calcitonin gene-related peptide type 1 receptor isoform X1

    See identical proteins and their annotated locations for XP_006499981.1

    UniProtKB/Swiss-Prot
    Q9R1W5, Q9WUP2
    UniProtKB/TrEMBL
    A2AR99
    Related
    ENSMUSP00000097527.4, ENSMUST00000099944.4
    Conserved Domains (2) summary
    cd15274
    Location:137410
    7tmB1_calcitonin_R; calcitonin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors
    pfam02793
    Location:61128
    HRM; Hormone receptor domain
  2. XM_036162403.1XP_036018296.1  calcitonin gene-related peptide type 1 receptor isoform X1

    UniProtKB/Swiss-Prot
    Q9WUP2
    UniProtKB/TrEMBL
    A2AR99
    Conserved Domains (2) summary
    cd15274
    Location:137410
    7tmB1_calcitonin_R; calcitonin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors
    pfam02793
    Location:61128
    HRM; Hormone receptor domain