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Calcrl calcitonin receptor-like [ Mus musculus (house mouse) ]

Gene ID: 54598, updated on 18-Apr-2019

Summary

Official Symbol
Calcrlprovided by MGI
Official Full Name
calcitonin receptor-likeprovided by MGI
Primary source
MGI:MGI:1926944
See related
Ensembl:ENSMUSG00000059588
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CRLR; AV071593
Expression
Biased expression in lung adult (RPKM 53.6), bladder adult (RPKM 7.2) and 3 other tissues See more
Orthologs

Genomic context

See Calcrl in Genome Data Viewer
Location:
2; 2 D
Exon count:
16
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (84330626..84425426, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (84170783..84265423, complement)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene CWC22 spliceosome-associated protein homolog pseudogene Neighboring gene CWC22 spliceosome-associated protein homolog pseudogene Neighboring gene tissue factor pathway inhibitor Neighboring gene predicted gene 13710

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
adrenomedullin binding ISO
Inferred from Sequence Orthology
more info
 
adrenomedullin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adrenomedullin receptor activity ISO
Inferred from Sequence Orthology
more info
 
calcitonin gene-related peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcitonin gene-related peptide receptor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
calcitonin gene-related peptide receptor activity ISO
Inferred from Sequence Orthology
more info
 
calcitonin receptor activity IEA
Inferred from Electronic Annotation
more info
 
transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
adrenomedullin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
angiogenesis ISO
Inferred from Sequence Orthology
more info
 
calcitonin gene-related peptide receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cellular response to sucrose stimulus ISO
Inferred from Sequence Orthology
more info
 
heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
negative regulation of smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein transport ISO
Inferred from Sequence Orthology
more info
 
receptor internalization ISO
Inferred from Sequence Orthology
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
CGRP receptor complex ISO
Inferred from Sequence Orthology
more info
 
adrenomedullin receptor complex ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
endosome ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
lysosome ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
calcitonin gene-related peptide type 1 receptor
Names
CGRP type 1 receptor
calcitonin receptor-like receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018782.2NP_061252.2  calcitonin gene-related peptide type 1 receptor precursor

    See identical proteins and their annotated locations for NP_061252.2

    Status: VALIDATED

    Source sequence(s)
    AF146525, AF209905, AK137210, CB595628, DY245973
    Consensus CDS
    CCDS16184.1
    UniProtKB/Swiss-Prot
    Q9R1W5
    UniProtKB/TrEMBL
    A2AR99
    Related
    ENSMUSP00000073875.2, ENSMUST00000074262.8
    Conserved Domains (2) summary
    pfam00002
    Location:137379
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:61128
    HRM; Hormone receptor domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

    Range
    84330626..84425426 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499918.3XP_006499981.1  calcitonin gene-related peptide type 1 receptor isoform X1

    See identical proteins and their annotated locations for XP_006499981.1

    UniProtKB/Swiss-Prot
    Q9R1W5
    UniProtKB/TrEMBL
    A2AR99
    Related
    ENSMUSP00000097527.3, ENSMUST00000099944.3
    Conserved Domains (2) summary
    pfam00002
    Location:137379
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:61128
    HRM; Hormone receptor domain
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