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Ptprh protein tyrosine phosphatase receptor type H [ Mus musculus (house mouse) ]

Gene ID: 545902, updated on 2-Nov-2024

Summary

Official Symbol
Ptprhprovided by MGI
Official Full Name
protein tyrosine phosphatase receptor type Hprovided by MGI
Primary source
MGI:MGI:3026877
See related
Ensembl:ENSMUSG00000035429 AllianceGenome:MGI:3026877
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
sap-1; R-PTP-H
Summary
Predicted to enable cadherin binding activity and protein tyrosine phosphatase activity. Involved in peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity. Located in microvillus. Is expressed in intestine; stomach; and testis. Orthologous to human PTPRH (protein tyrosine phosphatase receptor type H). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in large intestine adult (RPKM 59.8), small intestine adult (RPKM 50.8) and 3 other tissues See more
Orthologs
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Genomic context

See Ptprh in Genome Data Viewer
Location:
7 A1; 7 2.63 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (4551607..4607040, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (4548608..4604041, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene troponin I, cardiac 3 Neighboring gene dynein, axonemal assembly factor 3 Neighboring gene synaptotagmin V Neighboring gene hematological and neurological expressed 1-like pseudogene Neighboring gene predicted gene 9463

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cadherin binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in microvillus IDA
Inferred from Direct Assay
more info
PubMed 
located_in microvillus membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
receptor-type tyrosine-protein phosphatase H
Names
receptor type protein tyrosine phosphatase sap-1
stomach cancer-associated protein tyrosine phosphatase 1
NP_997153.2
XP_006540267.1
XP_011248936.1
XP_011248937.1
XP_011248938.1
XP_011248939.1
XP_011248940.1
XP_011248941.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207270.3NP_997153.2  receptor-type tyrosine-protein phosphatase H precursor

    Status: VALIDATED

    Source sequence(s)
    AC161197, AC161218
    Consensus CDS
    CCDS51974.1
    UniProtKB/Swiss-Prot
    B6ZDS3, E9Q0N2, Q8BIW7
    Related
    ENSMUSP00000125833.2, ENSMUST00000166650.3
    Conserved Domains (4) summary
    smart00060
    Location:156234
    FN3; Fibronectin type 3 domain
    smart00194
    Location:670929
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:698928
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:67146
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    4551607..4607040 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011250634.3XP_011248936.1  receptor-type tyrosine-protein phosphatase H isoform X1

    Conserved Domains (3) summary
    smart00060
    Location:334412
    FN3; Fibronectin type 3 domain
    cd00063
    Location:67146
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl28904
    Location:8811113
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  2. XM_006540204.4XP_006540267.1  receptor-type tyrosine-protein phosphatase H isoform X6

    Conserved Domains (3) summary
    smart00060
    Location:518594
    FN3; Fibronectin type 3 domain
    cd00063
    Location:67146
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl28904
    Location:7881020
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  3. XM_011250635.3XP_011248937.1  receptor-type tyrosine-protein phosphatase H isoform X2

    Conserved Domains (3) summary
    smart00060
    Location:334412
    FN3; Fibronectin type 3 domain
    cd00063
    Location:67146
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl28904
    Location:8771109
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  4. XM_011250639.3XP_011248941.1  receptor-type tyrosine-protein phosphatase H isoform X7

    Conserved Domains (3) summary
    smart00060
    Location:334412
    FN3; Fibronectin type 3 domain
    cd00063
    Location:67146
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl28904
    Location:7881020
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  5. XM_011250636.3XP_011248938.1  receptor-type tyrosine-protein phosphatase H isoform X3

    Conserved Domains (3) summary
    smart00060
    Location:334412
    FN3; Fibronectin type 3 domain
    cd00063
    Location:67146
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl28904
    Location:8771109
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  6. XM_011250638.3XP_011248940.1  receptor-type tyrosine-protein phosphatase H isoform X5

    Conserved Domains (3) summary
    smart00060
    Location:334412
    FN3; Fibronectin type 3 domain
    cd00063
    Location:67146
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl28904
    Location:7921024
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  7. XM_011250637.3XP_011248939.1  receptor-type tyrosine-protein phosphatase H isoform X4

    Conserved Domains (3) summary
    smart00060
    Location:288366
    FN3; Fibronectin type 3 domain
    cd00063
    Location:21100
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl28904
    Location:8351067
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

RNA

  1. XR_003946524.1 RNA Sequence

  2. XR_881746.3 RNA Sequence