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DLL4 delta like canonical Notch ligand 4 [ Homo sapiens (human) ]

Gene ID: 54567, updated on 13-May-2022

Summary

Official Symbol
DLL4provided by HGNC
Official Full Name
delta like canonical Notch ligand 4provided by HGNC
Primary source
HGNC:HGNC:2910
See related
Ensembl:ENSG00000128917 MIM:605185; AllianceGenome:HGNC:2910
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AOS6; delta4; hdelta2
Summary
This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. [provided by RefSeq, Jul 2008]
Expression
Broad expression in placenta (RPKM 11.5), fat (RPKM 11.2) and 22 other tissues See more
Orthologs
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Genomic context

See DLL4 in Genome Data Viewer
Location:
15q15.1
Exon count:
11
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (40929340..40939073)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (38735323..38745058)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (41221538..41231271)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 6315 Neighboring gene uncharacterized LOC105370943 Neighboring gene iron-sulfur cluster assembly 1 pseudogene 4 Neighboring gene ChaC glutathione specific gamma-glutamylcyclotransferase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Adams-Oliver syndrome 6
MedGen: C4225271 OMIM: 616589 GeneReviews: Adams-Oliver Syndrome
Compare labs

EBI GWAS Catalog

Description
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126344

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables Notch binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in Notch signaling involved in heart development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in T cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in aortic valve morphogenesis IC
Inferred by Curator
more info
PubMed 
involved_in blood circulation TAS
Traceable Author Statement
more info
PubMed 
involved_in blood vessel lumenization IEA
Inferred from Electronic Annotation
more info
 
involved_in blood vessel remodeling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in branching involved in blood vessel morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cardiac atrium morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cardiac ventricle morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to fibroblast growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to vascular endothelial growth factor stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dorsal aorta morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of Notch signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell migration involved in sprouting angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell migration involved in sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in pericardium morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of Notch signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of neural precursor cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of neural retina development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of neurogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
involved_in ventral spinal cord interneuron fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ventricular trabecula myocardium morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in visual perception IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
delta-like protein 4
Names
delta 4
delta ligand 4
delta-like 4 homolog
delta-like 4 protein
drosophila Delta homolog 4
notch ligand DLL4
notch ligand delta-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046974.1 RefSeqGene

    Range
    5008..14741
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1268

mRNA and Protein(s)

  1. NM_019074.4NP_061947.1  delta-like protein 4 precursor

    See identical proteins and their annotated locations for NP_061947.1

    Status: REVIEWED

    Source sequence(s)
    AB036931, AI478830, BC106950, DA089757, HY291308
    Consensus CDS
    CCDS45232.1
    UniProtKB/Swiss-Prot
    Q9NR61
    Related
    ENSP00000249749.5, ENST00000249749.7
    Conserved Domains (3) summary
    cd00054
    Location:327360
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam01414
    Location:155217
    DSL; Delta serrate ligand
    pfam07657
    Location:2788
    MNNL; N terminus of Notch ligand

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    40929340..40939073
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    38735323..38745058
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)