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POU3F4 POU class 3 homeobox 4 [ Homo sapiens (human) ]

Gene ID: 5456, updated on 8-Dec-2018

Summary

Official Symbol
POU3F4provided by HGNC
Official Full Name
POU class 3 homeobox 4provided by HGNC
Primary source
HGNC:HGNC:9217
See related
Ensembl:ENSG00000196767 MIM:300039
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BRN4; DFN3; OTF9; BRN-4; DFNX2; OCT-9; OTF-9; BRAIN-4
Summary
This gene encodes a member of the POU-III class of neural transcription factors. This family member plays a role in inner ear development. The protein is thought to be involved in the mediation of epigenetic signals which induce striatal neuron-precursor differentiation. Mutations in this gene are associated with X chromosome-linked nonsyndromic mixed deafness. [provided by RefSeq, Dec 2012]
Orthologs

Genomic context

See POU3F4 in Genome Data Viewer
Location:
Xq21.1
Exon count:
1
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) X NC_000023.11 (83508261..83509767)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (82763269..82764775)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene autophagy related 4A cysteine peptidase pseudogene 1 Neighboring gene uncharacterized LOC107985635 Neighboring gene proteasome maturation protein pseudogene Neighboring gene telomeric repeat binding factor 1 pseudogene 4

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cochlea morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
forebrain neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of mesenchymal cell apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
sensory perception of sound IEA
Inferred from Electronic Annotation
more info
 
transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
POU domain, class 3, transcription factor 4
Names
brain-specific homeobox/POU domain protein 4
octamer-binding transcription factor 9

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_009936.2 RefSeqGene

    Range
    5001..6507
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000307.4NP_000298.3  POU domain, class 3, transcription factor 4

    See identical proteins and their annotated locations for NP_000298.3

    Status: REVIEWED

    Source sequence(s)
    AK314967, X82324, Z82170
    Consensus CDS
    CCDS14450.1
    UniProtKB/Swiss-Prot
    P49335
    Related
    ENSP00000362296.2, ENST00000373200.5
    Conserved Domains (2) summary
    smart00352
    Location:186260
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:281334
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p12 Primary Assembly

    Range
    83508261..83509767
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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