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Amy2b amylase 2b [ Mus musculus (house mouse) ]

Gene ID: 545562, updated on 16-Sep-2018

Summary

Official Symbol
Amy2bprovided by MGI
Official Full Name
amylase 2bprovided by MGI
Primary source
MGI:MGI:104547
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PA; Amy2; Amy-X; Amy2a; Amy2-2; mAmy2-1
Summary
Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The mouse genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the pancreas. At least one mouse strain has a non-functional allele of this gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2011]
Expression
Biased expression in small intestine adult (RPKM 369.0), spleen adult (RPKM 271.2) and 2 other tissues See more

Genomic context

See Amy2b in Genome Data Viewer
Location:
3 F3; 3 49.35 cM
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (113147656..113156727, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (112950574..112959645, complement)

Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene leptin receptor gene-related protein pseudogene Neighboring gene predicted pseudogene 38395 Neighboring gene amylase 2, pseudogene 1 Neighboring gene amylase 2a5

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Pathways from BioSystems

  • Pancreatic secretion, organism-specific biosystem (from KEGG)
    Pancreatic secretion, organism-specific biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
  • Pancreatic secretion, conserved biosystem (from KEGG)
    Pancreatic secretion, conserved biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...

General gene information

Markers

Clone Names

  • MGC175496, MGC183419

General protein information

Preferred Names
amylase 2b
Names
1,4-alpha-D-glucan glucanohydrolase
Pancreatic alpha-amylase
amylase 2-2, pancreatic
amylase 2b, pancreatic
NP_001177332.1
NP_001177333.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190403.1NP_001177332.1  amylase 2b isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC121826
    Conserved Domains (2) summary
    cd11317
    Location:25358
    AmyAc_bac_euk_AmyA; Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase)
    smart00632
    Location:364452
    Aamy_C; Aamy_C domain
  2. NM_001190404.1NP_001177333.1  amylase 2b isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AC121826
    Conserved Domains (2) summary
    cd11317
    Location:25336
    AmyAc_bac_euk_AmyA; Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase)
    smart00632
    Location:342430
    Aamy_C; Aamy_C domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

    Range
    113147656..113156727 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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