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GNL3L G protein nucleolar 3 like [ Homo sapiens (human) ]

Gene ID: 54552, updated on 8-Jan-2023

Summary

Official Symbol
GNL3Lprovided by HGNC
Official Full Name
G protein nucleolar 3 likeprovided by HGNC
Primary source
HGNC:HGNC:25553
See related
Ensembl:ENSG00000130119 MIM:300873; AllianceGenome:HGNC:25553
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GNL3B
Summary
The protein encoded by this gene appears to be a nucleolar GTPase that is essential for ribosomal pre-rRNA processing and cell proliferation. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]
Expression
Ubiquitous expression in thyroid (RPKM 3.6), appendix (RPKM 3.3) and 25 other tissues See more
Orthologs
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Genomic context

See GNL3L in Genome Data Viewer
Location:
Xp11.22
Exon count:
20
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (54530219..54645854)
110 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (53821079..53858149)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (54556652..54593722)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene WNK lysine deficient protein kinase 3 Neighboring gene RNA, U6 small nuclear 434, pseudogene Neighboring gene TSR2 ribosome maturation factor Neighboring gene FYVE, RhoGEF and PH domain containing 1 Neighboring gene phosphoglycerate mutase family member 4 pseudogene 1 Neighboring gene inter-alpha-trypsin inhibitor heavy chain family member 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10613

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in membrane HDA PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
part_of telomerase holoenzyme complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
guanine nucleotide-binding protein-like 3-like protein
Names
G protein nucleolar 3B
guanine nucleotide binding protein-like 3 (nucleolar)-like
novel GTPase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021314.2 RefSeqGene

    Range
    5002..42072
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184819.2NP_001171748.1  guanine nucleotide-binding protein-like 3-like protein

    See identical proteins and their annotated locations for NP_001171748.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AK001475, AL391139, BC003603, BQ674906
    Consensus CDS
    CCDS14360.1
    UniProtKB/Swiss-Prot
    Q9NVN8
    UniProtKB/TrEMBL
    A0A024R9Y6, Q05DU1
    Related
    ENSP00000354091.2, ENST00000360845.3
    Conserved Domains (2) summary
    cd04178
    Location:136307
    Nucleostemin_like; A circularly permuted subfamily of the Ras GTPases
    COG3596
    Location:251405
    YeeP; Predicted GTPase [General function prediction only]
  2. NM_019067.6NP_061940.1  guanine nucleotide-binding protein-like 3-like protein

    See identical proteins and their annotated locations for NP_061940.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AK001475, AL391139, BQ674906
    Consensus CDS
    CCDS14360.1
    UniProtKB/Swiss-Prot
    Q9NVN8
    UniProtKB/TrEMBL
    A0A024R9Y6
    Related
    ENSP00000338573.4, ENST00000336470.8
    Conserved Domains (2) summary
    cd04178
    Location:136307
    Nucleostemin_like; A circularly permuted subfamily of the Ras GTPases
    COG3596
    Location:251405
    YeeP; Predicted GTPase [General function prediction only]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    54530219..54645854
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047442190.1XP_047298146.1  guanine nucleotide-binding protein-like 3-like protein isoform X1

    UniProtKB/Swiss-Prot
    Q9NVN8
    UniProtKB/TrEMBL
    A0A024R9Y6
    Related
    ENSP00000501452.1, ENST00000674311.1
  2. XM_047442189.1XP_047298145.1  guanine nucleotide-binding protein-like 3-like protein isoform X1

    UniProtKB/Swiss-Prot
    Q9NVN8
    UniProtKB/TrEMBL
    A0A024R9Y6
    Related
    ENSP00000501411.1, ENST00000674498.1

RNA

  1. XR_007068190.1 RNA Sequence

  2. XR_007068191.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    53821079..53858149
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)