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SDK2 sidekick cell adhesion molecule 2 [ Homo sapiens (human) ]

Gene ID: 54549, updated on 7-Dec-2018

Summary

Official Symbol
SDK2provided by HGNC
Official Full Name
sidekick cell adhesion molecule 2provided by HGNC
Primary source
HGNC:HGNC:19308
See related
Ensembl:ENSG00000069188 MIM:607217
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a member of the immunoglobulin superfamily. The protein contains two immunoglobulin domains and thirteen fibronectin type III domains. Fibronectin type III domains are present in both extracellular and intracellular proteins and tandem repeats are known to contain binding sites for DNA, heparin and the cell surface. This protein, and a homologous mouse sequence, are very similar to the Drosophila sidekick gene product but the specific function of this superfamily member is not yet known. Evidence for alternative splicing at this gene locus has been observed but the full-length nature of additional variants has not yet been determined. [provided by RefSeq, Jul 2008]
Expression
Biased expression in testis (RPKM 6.4), spleen (RPKM 1.7) and 8 other tissues See more
Orthologs

Genomic context

See SDK2 in Genome Data Viewer
Location:
17q25.1
Exon count:
47
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (73334384..73644481, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (71330523..71640227, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene chromosome 17 open reading frame 80 Neighboring gene cleavage and polyadenylation specific factor 4 like Neighboring gene CDC42 effector protein 4 Neighboring gene uncharacterized LOC101928251 Neighboring gene uncharacterized LOC107985091 Neighboring gene uncharacterized LOC100134391 Neighboring gene long intergenic non-protein coding RNA 469

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10832, KIAA1514

Gene Ontology Provided by GOA

Process Evidence Code Pubs
camera-type eye photoreceptor cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
cell-cell junction organization TAS
Traceable Author Statement
more info
 
homophilic cell adhesion via plasma membrane adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
homophilic cell adhesion via plasma membrane adhesion molecules ISS
Inferred from Sequence or Structural Similarity
more info
 
retina layer formation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
retina layer formation ISS
Inferred from Sequence or Structural Similarity
more info
 
synapse assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synapse assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cell junction IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synapse ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
protein sidekick-2
Names
sidekick homolog 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001144952.2NP_001138424.1  protein sidekick-2 precursor

    See identical proteins and their annotated locations for NP_001138424.1

    Status: VALIDATED

    Source sequence(s)
    AB040947, AC032019, AC087301, AC124804, BC066363
    Consensus CDS
    CCDS45769.1
    UniProtKB/Swiss-Prot
    Q58EX2
    Related
    ENSP00000376421.3, ENST00000392650.7
    Conserved Domains (6) summary
    cd00096
    Location:326394
    Ig; Immunoglobulin domain
    smart00408
    Location:233286
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:502586
    IG_like; Immunoglobulin like
    cd00063
    Location:16261719
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:402492
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:416492
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    73334384..73644481 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011524915.2XP_011523217.1  protein sidekick-2 isoform X2

    Conserved Domains (6) summary
    cd00096
    Location:326394
    Ig; Immunoglobulin domain
    smart00408
    Location:233286
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:502586
    IG_like; Immunoglobulin like
    cd00063
    Location:16261719
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:402492
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:416492
    Ig; Immunoglobulin domain
  2. XM_011524914.2XP_011523216.1  protein sidekick-2 isoform X1

    UniProtKB/Swiss-Prot
    Q58EX2
    Conserved Domains (6) summary
    cd00096
    Location:326394
    Ig; Immunoglobulin domain
    smart00408
    Location:233286
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:502586
    IG_like; Immunoglobulin like
    cd00063
    Location:16071700
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:402492
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:416492
    Ig; Immunoglobulin domain
  3. XM_011524916.3XP_011523218.1  protein sidekick-2 isoform X3

    Conserved Domains (6) summary
    cd00096
    Location:326394
    Ig; Immunoglobulin domain
    smart00408
    Location:233286
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:502586
    IG_like; Immunoglobulin like
    cd00063
    Location:590681
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:402492
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:416492
    Ig; Immunoglobulin domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_019064.3: Suppressed sequence

    Description
    NM_019064.3: This RefSeq was temporarily suppressed because the CDS was partial.
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