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Tubb1 tubulin, beta 1 class VI [ Mus musculus (house mouse) ]

Gene ID: 545486, updated on 11-Apr-2024

Summary

Official Symbol
Tubb1provided by MGI
Official Full Name
tubulin, beta 1 class VIprovided by MGI
Primary source
MGI:MGI:107814
See related
Ensembl:ENSMUSG00000016255 AllianceGenome:MGI:107814
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
M(beta)1; 2810484G07Rik
Summary
A structural constituent of cytoskeleton. Acts upstream of or within spindle assembly. Located in microtubule. Is expressed in dorsal root ganglion; liver; and spinal cord. Human ortholog(s) of this gene implicated in autosomal dominant macrothrombocytopenia TUBB1-related. Orthologous to human TUBB1 (tubulin beta 1 class VI). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 21.1), liver E14 (RPKM 14.7) and 6 other tissues See more
Orthologs
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Genomic context

Location:
2 H4; 2 97.95 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (174292388..174300173)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (174450595..174458380)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene negative elongation factor complex member C/D, Th1l Neighboring gene cathepsin Z Neighboring gene STARR-positive B cell enhancer ABC_E6030 Neighboring gene ribosomal protein L30, pseudogene 5 Neighboring gene STARR-seq mESC enhancer starr_06641 Neighboring gene ATP synthase F1 subunit epsilon Neighboring gene PRELI domain containing 3B Neighboring gene STARR-positive B cell enhancer ABC_E6031

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables structural constituent of cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
enables structural constituent of cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in microtubule polymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within microtubule-based process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in platelet aggregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in platelet formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within spindle assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in thyroid gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in thyroid hormone transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in microtubule IDA
Inferred from Direct Assay
more info
PubMed 
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080971.2NP_001074440.1  tubulin beta-1 chain

    See identical proteins and their annotated locations for NP_001074440.1

    Status: VALIDATED

    Source sequence(s)
    AL844534
    Consensus CDS
    CCDS38359.1
    UniProtKB/Swiss-Prot
    A2AQ07
    Related
    ENSMUSP00000016399.6, ENSMUST00000016399.6
    Conserved Domains (2) summary
    PTZ00010
    Location:1428
    PTZ00010; tubulin beta chain; Provisional
    cd02187
    Location:2426
    beta_tubulin; The beta-tubulin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    174292388..174300173
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)