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ROBO4 roundabout guidance receptor 4 [ Homo sapiens (human) ]

Gene ID: 54538, updated on 20-Dec-2019

Summary

Official Symbol
ROBO4provided by HGNC
Official Full Name
roundabout guidance receptor 4provided by HGNC
Primary source
HGNC:HGNC:17985
See related
Ensembl:ENSG00000154133 MIM:607528
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MRB; AOVD3; ECSM4
Expression
Broad expression in fat (RPKM 35.9), spleen (RPKM 32.4) and 17 other tissues See more
Orthologs

Genomic context

See ROBO4 in Genome Data Viewer
Location:
11q24.2
Exon count:
18
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (124883691..124897865, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (124754114..124767857, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100507283 Neighboring gene E3 ubiquitin-protein ligase RNF181 pseudogene Neighboring gene roundabout guidance receptor 3 Neighboring gene uncharacterized LOC107984406 Neighboring gene hepatic and glial cell adhesion molecule Neighboring gene hepatocellular carcinoma, down-regulated 1 Neighboring gene CCDC15 divergent transcript

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Interaction of SLIT2 with Robo4 significantly inhibits HIV-1 gp120-induced phosphorylation of c-Src in human lymphatic endothelial cells PubMed
env HIV-1 gp120 induces phosphorylation of fibronectin and enhances a physical association between fibronectin and Robo4 in human lymphatic endothelial cells PubMed
env The fibronectin domains of Robo4 are critical for HIV-1 gp120-induced hyperpermeability of human lymphatic endothelial cell monolayers PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20798, MGC133352, MGC133353

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cell-cell adhesion mediator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
angiogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dendrite self-avoidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
homophilic cell adhesion via plasma membrane adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cell migration NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular exosome HDA PubMed 
integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
roundabout homolog 4
Names
roundabout homolog 4, magic roundabout
roundabout, axon guidance receptor, homolog 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301088.2NP_001288017.1  roundabout homolog 4 isoform 2

    See identical proteins and their annotated locations for NP_001288017.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction at the 5' end of the second exon and starts translation at a downstream AUG compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AF361473, AK302628, AP003501, DC424813
    Consensus CDS
    CCDS73409.1
    UniProtKB/Swiss-Prot
    Q8WZ75
    UniProtKB/TrEMBL
    B4DYV8
    Related
    ENSP00000437129.1, ENST00000533054.5
    Conserved Domains (3) summary
    smart00410
    Location:175
    IG_like; Immunoglobulin like
    pfam00041
    Location:205287
    fn3; Fibronectin type III domain
    cl11960
    Location:180
    Ig; Immunoglobulin domain
  2. NM_019055.6NP_061928.4  roundabout homolog 4 isoform 1 precursor

    See identical proteins and their annotated locations for NP_061928.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF361473, AP003501, DC424813
    Consensus CDS
    CCDS8455.1
    UniProtKB/Swiss-Prot
    Q8WZ75
    Related
    ENSP00000304945.3, ENST00000306534.8
    Conserved Domains (4) summary
    cd05724
    Location:141225
    Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    pfam07679
    Location:139220
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:350432
    fn3; Fibronectin type III domain
    cl11960
    Location:31133
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    124883691..124897865 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006718861.2XP_006718924.1  roundabout homolog 4 isoform X1

    Conserved Domains (4) summary
    cd05724
    Location:141225
    Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    pfam07679
    Location:139220
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:350432
    fn3; Fibronectin type III domain
    cl11960
    Location:31133
    Ig; Immunoglobulin domain
  2. XM_011542875.1XP_011541177.1  roundabout homolog 4 isoform X2

    Conserved Domains (1) summary
    PHA03247
    Location:125434
    PHA03247; large tegument protein UL36; Provisional
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