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SHLD2 shieldin complex subunit 2 [ Homo sapiens (human) ]

Gene ID: 54537, updated on 23-Nov-2021

Summary

Official Symbol
SHLD2provided by HGNC
Official Full Name
shieldin complex subunit 2provided by HGNC
Primary source
HGNC:HGNC:28773
See related
Ensembl:ENSG00000122376 MIM:618029
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RINN2; FAM35A; FAM35A1; bA163M19.1
Expression
Ubiquitous expression in kidney (RPKM 20.9), thyroid (RPKM 14.9) and 25 other tissues See more
Orthologs
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Genomic context

See SHLD2 in Genome Data Viewer
Location:
10q23.2
Exon count:
22
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (87094478..87191468)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (88854963..88951222)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 4381 Neighboring gene RNA, U6 small nuclear 529, pseudogene Neighboring gene glutamate dehydrogenase 1 Neighboring gene RNA, 7SL, cytoplasmic 733, pseudogene Neighboring gene uncharacterized LOC105378410 Neighboring gene NUTM2A antisense RNA 1 Neighboring gene NUT family member 2A Neighboring gene long intergenic non-protein coding RNA 863

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC5560

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in chromosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in site of double-strand break IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in site of double-strand break IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
shieldin complex subunit 2
Names
RINN1-REV7-interacting novel NHEJ regulator 2
family with sequence similarity 35 member A
protein FAM35A
shield complex subunit 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330112.2NP_001317041.1  shieldin complex subunit 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL136982, AL645992
    Consensus CDS
    CCDS81484.1
    UniProtKB/Swiss-Prot
    Q86V20
    Related
    ENSP00000298786.3, ENST00000298786.5
    Conserved Domains (1) summary
    pfam15793
    Location:720892
    FAM35_C; Protein family FAM35, C-terminal
  2. NM_001377158.1NP_001364087.1  shieldin complex subunit 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), as well as variants 2 and 4, encodes isoform 2.
    Source sequence(s)
    AL136982, AL645992
    Conserved Domains (1) summary
    pfam15793
    Location:655823
    FAM35_C; Protein family FAM35, C-terminal
  3. NM_001377159.1NP_001364088.1  shieldin complex subunit 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variants 2 and 3, encodes isoform 2.
    Source sequence(s)
    AL136982, AL645992
    Conserved Domains (1) summary
    pfam15793
    Location:655823
    FAM35_C; Protein family FAM35, C-terminal
  4. NM_001377160.1NP_001364089.1  shieldin complex subunit 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL136982, AL645992
    Conserved Domains (1) summary
    pfam15793
    Location:703871
    FAM35_C; Protein family FAM35, C-terminal
  5. NM_001377161.1NP_001364090.1  shieldin complex subunit 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL136982, AL645992
    Conserved Domains (1) summary
    pfam15793
    Location:722875
    FAM35_C; Protein family FAM35, C-terminal
  6. NM_001377162.1NP_001364091.1  shieldin complex subunit 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL136982, AL645992
    Conserved Domains (1) summary
    pfam15793
    Location:685856
    FAM35_C; Protein family FAM35, C-terminal
  7. NM_001377163.1NP_001364092.1  shieldin complex subunit 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL136982, AL645992
    Conserved Domains (1) summary
    pfam15793
    Location:721840
    FAM35_C; Protein family FAM35, C-terminal
  8. NM_001377164.1NP_001364093.1  shieldin complex subunit 2 isoform 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9), as well as variant 10, encodes isoform 7.
    Source sequence(s)
    AL136982, AL645992
    Conserved Domains (1) summary
    pfam15793
    Location:619787
    FAM35_C; Protein family FAM35, C-terminal
  9. NM_001377165.1NP_001364094.1  shieldin complex subunit 2 isoform 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10), as well as variant 9, encodes isoform 7.
    Source sequence(s)
    AL136982, AL645992
    Conserved Domains (1) summary
    pfam15793
    Location:619787
    FAM35_C; Protein family FAM35, C-terminal
  10. NM_001377166.1NP_001364095.1  shieldin complex subunit 2 isoform 8

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11), as well as variants 12 and 13, encodes isoform 8.
    Source sequence(s)
    AL136982, AL645992
    Conserved Domains (1) summary
    pfam15793
    Location:372543
    FAM35_C; Protein family FAM35, C-terminal
  11. NM_001377167.1NP_001364096.1  shieldin complex subunit 2 isoform 8

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12), as well as variants 11 and 13, encodes isoform 8.
    Source sequence(s)
    AL136982, AL645992
    Conserved Domains (1) summary
    pfam15793
    Location:372543
    FAM35_C; Protein family FAM35, C-terminal
  12. NM_001377168.1NP_001364097.1  shieldin complex subunit 2 isoform 8

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13), as well as variants 11 and 12, encodes isoform 8.
    Source sequence(s)
    AL136982, AL645992
    Conserved Domains (1) summary
    pfam15793
    Location:372543
    FAM35_C; Protein family FAM35, C-terminal
  13. NM_001377169.1NP_001364098.1  shieldin complex subunit 2 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL136982, AL645992
    Conserved Domains (1) summary
    pfam15793
    Location:372520
    FAM35_C; Protein family FAM35, C-terminal
  14. NM_001377170.1NP_001364099.1  shieldin complex subunit 2 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL136982, AL645992
    Conserved Domains (1) summary
    pfam15793
    Location:253424
    FAM35_C; Protein family FAM35, C-terminal
  15. NM_001377171.1NP_001364100.1  shieldin complex subunit 2 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AL136982, AL645992
    Conserved Domains (1) summary
    pfam15793
    Location:404575
    FAM35_C; Protein family FAM35, C-terminal
  16. NM_001377172.1NP_001364101.1  shieldin complex subunit 2 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AL136982, AL645992
    Conserved Domains (1) summary
    pfam15793
    Location:306474
    FAM35_C; Protein family FAM35, C-terminal
  17. NM_019054.3NP_061927.2  shieldin complex subunit 2 isoform 2

    See identical proteins and their annotated locations for NP_061927.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1. Variants 2-4 all encode the same isoform (2).
    Source sequence(s)
    AK022978, BC051863
    Consensus CDS
    CCDS7383.1
    UniProtKB/Swiss-Prot
    Q86V20
    Related
    ENSP00000298784.1, ENST00000298784.5
    Conserved Domains (1) summary
    pfam15793
    Location:655823
    FAM35_C; Protein family FAM35, C-terminal

RNA

  1. NR_165105.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL136982, AL645992
  2. NR_165106.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL136982, AL645992
  3. NR_165108.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL136982, AL645992

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    87094478..87191468
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017016350.1XP_016871839.1  shieldin complex subunit 2 isoform X2

    Conserved Domains (1) summary
    pfam15793
    Location:769940
    FAM35_C; Protein family FAM35, C-terminal
  2. XM_017016349.1XP_016871838.1  shieldin complex subunit 2 isoform X1

    Conserved Domains (1) summary
    pfam15793
    Location:798969
    FAM35_C; Protein family FAM35, C-terminal
  3. XM_006717903.4XP_006717966.1  shieldin complex subunit 2 isoform X2

    See identical proteins and their annotated locations for XP_006717966.1

    Conserved Domains (1) summary
    pfam15793
    Location:769940
    FAM35_C; Protein family FAM35, C-terminal
  4. XM_011539877.2XP_011538179.1  shieldin complex subunit 2 isoform X2

    See identical proteins and their annotated locations for XP_011538179.1

    Conserved Domains (1) summary
    pfam15793
    Location:769940
    FAM35_C; Protein family FAM35, C-terminal
  5. XM_011539878.2XP_011538180.1  shieldin complex subunit 2 isoform X2

    See identical proteins and their annotated locations for XP_011538180.1

    Conserved Domains (1) summary
    pfam15793
    Location:769940
    FAM35_C; Protein family FAM35, C-terminal
  6. XM_011539879.2XP_011538181.1  shieldin complex subunit 2 isoform X2

    See identical proteins and their annotated locations for XP_011538181.1

    Conserved Domains (1) summary
    pfam15793
    Location:769940
    FAM35_C; Protein family FAM35, C-terminal
  7. XM_006717905.3XP_006717968.1  shieldin complex subunit 2 isoform X2

    See identical proteins and their annotated locations for XP_006717968.1

    Conserved Domains (1) summary
    pfam15793
    Location:769940
    FAM35_C; Protein family FAM35, C-terminal
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