Format

Send to:

Choose Destination

EXOC6 exocyst complex component 6 [ Homo sapiens (human) ]

Gene ID: 54536, updated on 7-Jun-2020

Summary

Official Symbol
EXOC6provided by HGNC
Official Full Name
exocyst complex component 6provided by HGNC
Primary source
HGNC:HGNC:23196
See related
Ensembl:ENSG00000138190 MIM:609672
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SEC15; EXOC6A; SEC15L; Sec15p; SEC15L1; SEC15L3
Summary
The protein encoded by this gene is highly similar to the Saccharomyces cerevisiae SEC15 gene product, which is essential for vesicular traffic from the Golgi apparatus to the cell surface in yeast. It is one of the components of a multiprotein complex required for exocytosis. The 5' portion of this gene and two neighboring cytochrome p450 genes are included in a deletion that results in an autosomal-dominant form of nonsyndromic optic nerve aplasia (ONA). Alternative splicing and the use of alternative promoters results in multiple transcript variants. A paralogous gene encoding a similar protein is present on chromosome 2. [provided by RefSeq, Jan 2016]
Expression
Ubiquitous expression in thyroid (RPKM 11.4), placenta (RPKM 9.4) and 25 other tissues See more
Orthologs

Genomic context

See EXOC6 in Genome Data Viewer
Location:
10q23.33
Exon count:
27
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (92826831..93059494)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (94590887..94819251)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene NUP98-HHEX recombination region Neighboring gene hematopoietically expressed homeobox Neighboring gene VISTA enhancer hs1866 Neighboring gene cytochrome P450 family 26 subfamily C member 1 Neighboring gene cytochrome P450 family 26 subfamily A member 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 Nef immunocomplexes analyzed by mass spectrometry reveal that exocyst complex component 6 (EXOC6) is a Nef-binding protein in Jurkat cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ1125, FLJ11251, MGC33397, DKFZp761I2124

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Golgi to plasma membrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein transport IEA
Inferred from Electronic Annotation
more info
 
vesicle docking involved in exocytosis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Flemming body IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
exocyst IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
growth cone IEA
Inferred from Electronic Annotation
more info
 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
exocyst complex component 6
Names
SEC15-like 1
SEC15-like protein 3
exocyst complex component Sec15A
rsec15-like protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013848.3NP_001013870.1  exocyst complex component 6 isoform b

    See identical proteins and their annotated locations for NP_001013870.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and initiates translation from a downstream in-frame start codon, compared to variant 3. The encoded isoform (b) is shorter at the N-terminus, compared to isoform c.
    Source sequence(s)
    AK128190, AK300285, AL832501, BC028395, BU674151
    Consensus CDS
    CCDS31247.1
    UniProtKB/Swiss-Prot
    Q8TAG9
    UniProtKB/TrEMBL
    B3KXY5, B7Z6G5
    Related
    ENSP00000500529.1, ENST00000671701.1
    Conserved Domains (1) summary
    pfam04091
    Location:451757
    Sec15; Exocyst complex subunit Sec15-like
  2. NM_001319194.2NP_001306123.1  exocyst complex component 6 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (c).
    Source sequence(s)
    AL157705, AL358613, AL392103, AL590080
    UniProtKB/Swiss-Prot
    Q8TAG9
    UniProtKB/TrEMBL
    B7Z6G5
    Conserved Domains (1) summary
    pfam04091
    Location:472778
    Sec15; Exocyst complex subunit Sec15-like
  3. NM_001319195.2NP_001306124.1  exocyst complex component 6 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two 5' exons but instead contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and 5' coding region, and it also uses an alternate in-frame splice site in the central coding region, compared to variant 3. The encoded isoform (d) has a distinct N-terminus and is shorter than isoform c.
    Source sequence(s)
    AL157705, AL358613, AL392103, AL590080
    UniProtKB/Swiss-Prot
    Q8TAG9
    Conserved Domains (1) summary
    pfam04091
    Location:456761
    Sec15; Exocyst complex subunit Sec15-like
  4. NM_001319200.1NP_001306129.1  exocyst complex component 6 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks two 5' exons but instead contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and 5' coding region, and it also lacks four internal exons resulting in the loss of two in-frame segments in the central coding region, compared to variant 3. The encoded isoform (e) has a distinct N-terminus and is shorter than isoform c.
    Source sequence(s)
    BC028395, BU674151, DA333847, EF571007
    Consensus CDS
    CCDS81487.1
    UniProtKB/Swiss-Prot
    Q8TAG9
    UniProtKB/TrEMBL
    A5YP36, E7EW84
    Related
    ENSP00000396206.2, ENST00000443748.6
    Conserved Domains (1) summary
    pfam04091
    Location:353659
    Sec15; Exocyst complex subunit Sec15-like
  5. NM_019053.6NP_061926.3  exocyst complex component 6 isoform a

    See identical proteins and their annotated locations for NP_061926.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks two 5' exons but instead contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and 5' coding region, compared to variant 3. The encoded isoform (a) has a distinct and shorter N-terminus, compared to isoform c.
    Source sequence(s)
    AL157705, AL358613, AL392103, AL590080
    Consensus CDS
    CCDS7424.2
    UniProtKB/Swiss-Prot
    Q8TAG9
    UniProtKB/TrEMBL
    B2RDH5
    Related
    ENSP00000260762.6, ENST00000260762.10
    Conserved Domains (1) summary
    pfam04091
    Location:456762
    Sec15; Exocyst complex subunit Sec15-like

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    92826831..93059494
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017016344.2XP_016871833.1  exocyst complex component 6 isoform X1

  2. XM_017016348.1XP_016871837.1  exocyst complex component 6 isoform X6

  3. XM_017016345.2XP_016871834.1  exocyst complex component 6 isoform X2

    UniProtKB/Swiss-Prot
    Q8TAG9
    Related
    ENSP00000360607.4, ENST00000371552.8
    Conserved Domains (1) summary
    pfam04091
    Location:451757
    Sec15; Exocyst complex subunit Sec15-like
  4. XM_017016346.2XP_016871835.1  exocyst complex component 6 isoform X3

  5. XM_024448047.1XP_024303815.1  exocyst complex component 6 isoform X5

    Conserved Domains (1) summary
    pfam04091
    Location:409715
    Sec15; Exocyst complex subunit Sec15-like
  6. XM_017016347.2XP_016871836.1  exocyst complex component 6 isoform X4

    Conserved Domains (1) summary
    pfam04091
    Location:435741
    Sec15; Exocyst complex subunit Sec15-like
Support Center