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MIER2 MIER family member 2 [ Homo sapiens (human) ]

Gene ID: 54531, updated on 5-Aug-2022

Summary

Official Symbol
MIER2provided by HGNC
Official Full Name
MIER family member 2provided by HGNC
Primary source
HGNC:HGNC:29210
See related
Ensembl:ENSG00000105556 AllianceGenome:HGNC:29210
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Mi-er2; KIAA1193
Summary
Enables histone deacetylase binding activity. Contributes to histone deacetylase activity. Involved in histone deacetylation. Located in cytoplasm and nucleus. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 6.0), spleen (RPKM 3.4) and 25 other tissues See more
Orthologs
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Genomic context

See MIER2 in Genome Data Viewer
Location:
19p13.3
Exon count:
16
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (305573..344796, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (255525..294230, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (305573..344796, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene PLPP2 intron CAGE-defined low expression enhancer Neighboring gene phospholipid phosphatase 2 Neighboring gene uncharacterized LOC124904605 Neighboring gene theg spermatid protein Neighboring gene uncharacterized LOC124904606

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Prognostic implications of genetic variants in advanced non-small cell lung cancer: a genome-wide association study.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to histone deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables histone deacetylase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables histone deacetylase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in histone deacetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in histone deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
mesoderm induction early response protein 2
Names
mesoderm induction early response 1, family member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001346105.2NP_001333034.1  mesoderm induction early response protein 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC016588
    Conserved Domains (2) summary
    cd11661
    Location:266310
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:161211
    ELM2; ELM2 domain
  2. NM_001387152.1NP_001374081.1  mesoderm induction early response protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC016588
    Conserved Domains (2) summary
    cd11661
    Location:304348
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:199249
    ELM2; ELM2 domain
  3. NM_001387153.1NP_001374082.1  mesoderm induction early response protein 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC016588
    Conserved Domains (3) summary
    cd11661
    Location:302346
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    TIGR01649
    Location:353457
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
    pfam01448
    Location:197247
    ELM2; ELM2 domain
  4. NM_001387154.1NP_001374083.1  mesoderm induction early response protein 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC016588
    Conserved Domains (3) summary
    cd11661
    Location:266310
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    TIGR01649
    Location:317421
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
    pfam01448
    Location:161211
    ELM2; ELM2 domain
  5. NM_001387155.1NP_001374084.1  mesoderm induction early response protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC016588
    Conserved Domains (2) summary
    cd11661
    Location:266310
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:161211
    ELM2; ELM2 domain
  6. NM_001387156.1NP_001374085.1  mesoderm induction early response protein 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC016588
    Conserved Domains (2) summary
    cd11661
    Location:218262
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:113163
    ELM2; ELM2 domain
  7. NM_001387157.1NP_001374086.1  mesoderm induction early response protein 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC016588
    Conserved Domains (2) summary
    cd11661
    Location:218262
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:113163
    ELM2; ELM2 domain
  8. NM_017550.3NP_060020.1  mesoderm induction early response protein 2 isoform 1

    See identical proteins and their annotated locations for NP_060020.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC016588
    Consensus CDS
    CCDS32855.1
    UniProtKB/Swiss-Prot
    Q8N344, Q9ULM7
    Related
    ENSP00000264819.3, ENST00000264819.7
    Conserved Domains (3) summary
    smart00717
    Location:301347
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd11661
    Location:302346
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:197247
    ELM2; ELM2 domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    305573..344796 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438972.1XP_047294928.1  mesoderm induction early response protein 2 isoform X5

  2. XM_047438970.1XP_047294926.1  mesoderm induction early response protein 2 isoform X2

  3. XM_047438978.1XP_047294934.1  mesoderm induction early response protein 2 isoform X5

  4. XM_006722769.5XP_006722832.1  mesoderm induction early response protein 2 isoform X4

    Conserved Domains (3) summary
    smart00717
    Location:303349
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd11661
    Location:304348
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:199249
    ELM2; ELM2 domain
  5. XM_047438971.1XP_047294927.1  mesoderm induction early response protein 2 isoform X3

  6. XM_047438969.1XP_047294925.1  mesoderm induction early response protein 2 isoform X1

  7. XM_047438977.1XP_047294933.1  mesoderm induction early response protein 2 isoform X5

  8. XM_047438976.1XP_047294932.1  mesoderm induction early response protein 2 isoform X5

  9. XM_047438975.1XP_047294931.1  mesoderm induction early response protein 2 isoform X5

  10. XM_047438974.1XP_047294930.1  mesoderm induction early response protein 2 isoform X5

  11. XM_047438973.1XP_047294929.1  mesoderm induction early response protein 2 isoform X5

  12. XM_047438979.1XP_047294935.1  mesoderm induction early response protein 2 isoform X6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    255525..294230 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)