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Cyp2c67 cytochrome P450, family 2, subfamily c, polypeptide 67 [ Mus musculus (house mouse) ]

Gene ID: 545288, updated on 8-Mar-2023

Summary

Official Symbol
Cyp2c67provided by MGI
Official Full Name
cytochrome P450, family 2, subfamily c, polypeptide 67provided by MGI
Primary source
MGI:MGI:3612288
See related
Ensembl:ENSMUSG00000062624 AllianceGenome:MGI:3612288
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C730004C24Rik
Summary
Predicted to enable several functions, including caffeine oxidase activity; heme binding activity; and monooxygenase activity. Predicted to be involved in epoxygenase P450 pathway and xenobiotic metabolic process. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in several diseases, including Plasmodium falciparum malaria; eosinophilic esophagitis; glucose metabolism disease (multiple); invasive aspergillosis; and multiple chemical sensitivity. Orthologous to human CYP2C19 (cytochrome P450 family 2 subfamily C member 19) and CYP2C9 (cytochrome P450 family 2 subfamily C member 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 101.5) and liver E18 (RPKM 45.4) See more
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Genomic context

See Cyp2c67 in Genome Data Viewer
Location:
19; 19 C3
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (39597288..39637523, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (39608844..39649079, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 2, subfamily c, polypeptide 72, pseudogene Neighboring gene cytochrome P450, family 2, subfamily c, polypeptide 39 Neighboring gene cytochrome P450, family 2, subfamily c, polypeptide 38 Neighboring gene cytochrome P450, family 2, subfamily c, polypeptide 68 Neighboring gene cytochrome P450, family 2, subfamily c, polypeptide 40

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

General gene information

Markers

Clone Names

  • MGC118068

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in epoxygenase P450 pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in xenobiotic metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cytochrome P450, family 2, subfamily c, polypeptide 67

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024719.3NP_001019890.1  cytochrome P450, family 2, subfamily c, polypeptide 67 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001019890.1

    Status: VALIDATED

    Source sequence(s)
    AC117790, AC157322
    Consensus CDS
    CCDS29796.1
    UniProtKB/TrEMBL
    E9QAE5, Q569X9
    Related
    ENSMUSP00000065796.7, ENSMUST00000067328.7
    Conserved Domains (1) summary
    pfam00067
    Location:30487
    p450; Cytochrome P450
  2. NM_001417644.1NP_001404573.1  cytochrome P450, family 2, subfamily c, polypeptide 67 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC117790, AC157322

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    39597288..39637523 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247291.2XP_011245593.1  cytochrome P450, family 2, subfamily c, polypeptide 67 isoform X1

    Conserved Domains (1) summary
    pfam00067
    Location:30477
    p450; Cytochrome P450