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Syt10 synaptotagmin X [ Mus musculus (house mouse) ]

Gene ID: 54526, updated on 8-Dec-2022

Summary

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Official Symbol
Syt10provided by MGI
Official Full Name
synaptotagmin Xprovided by MGI
Primary source
MGI:MGI:1859546
See related
Ensembl:ENSMUSG00000063260 AllianceGenome:MGI:1859546
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables several functions, including SNARE binding activity; phospholipid binding activity; and protein dimerization activity. Involved in chemical synaptic transmission; positive regulation of calcium ion-dependent exocytosis; and sensory perception of smell. Located in exocytic vesicle. Is expressed in several structures, including alimentary system; brain; cardiovascular system; ear; and skeleton. Orthologous to human SYT10 (synaptotagmin 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 3.7), cortex adult (RPKM 0.8) and 2 other tissues See more
Orthologs
human all
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Genomic context

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See Syt10 in Genome Data Viewer
Location:
15; 15 E3
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (89657221..89726181, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (89773714..89841980, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene NMD3 homolog pseudogene Neighboring gene predicted gene, 19378 Neighboring gene predicted gene, 36330 Neighboring gene predicted gene, 24415 Neighboring gene microRNA 7648 Neighboring gene asparagine-linked glycosylation 10B (alpha-1,2-glucosyltransferase)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of Synaptotagmin 10 as Effector of NPAS4-Mediated Protection from Excitotoxic Neurodegeneration. Woitecki AM, et al. J Neurosci, 2016 Mar 2. PMID 26936998, Free PMC Article
  2. Complexin activates exocytosis of distinct secretory vesicles controlled by different synaptotagmins. Cao P, et al. J Neurosci, 2013 Jan 23. PMID 23345244, Free PMC Article
  3. Synaptotagmin10-Cre, a driver to disrupt clock genes in the SCN. Husse J, et al. J Biol Rhythms, 2011 Oct. PMID 21921292
  4. The light-dark cycle controls peripheral rhythmicity in mice with a genetically ablated suprachiasmatic nucleus clock. Husse J, et al. FASEB J, 2014 Nov. PMID 25063847
  5. Acetylation of BMAL1 by TIP60 controls BRD4-P-TEFb recruitment to circadian promoters. Petkau N, et al. Elife, 2019 Jul 11. PMID 31294688, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Conditional deletion of synaptotagmin-10, the Ca(2+) sensor for IGF1 secretion from mitral cells, or deletion of IGF1 receptor in the olfactory bulb prevented the socially relevant GABAergic long-term potentiation and impaired memory formation after social transmission of food preference.
    Title: IGF1-Dependent Synaptic Plasticity of Mitral Cells in Olfactory Memory during Social Learning.
  2. This study demonstrated that Syt10 is required for NPAS4 to protect hippocampal neurons against excitotoxic cell death.
    Title: Identification of Synaptotagmin 10 as Effector of NPAS4-Mediated Protection from Excitotoxic Neurodegeneration.
  3. Study shows that olfactory bulb neurons secrete IGF-1 by an activity-dependent pathway of exocytosis, and that Syt10 functions as the Ca(2+)-sensor that triggers IGF-1 exocytosis in these neurons.
    Title: Activity-dependent IGF-1 exocytosis is controlled by the Ca(2+)-sensor synaptotagmin-10.
  4. Syt10 knockout mice imply that Syt10 protein acts to trigger insulin-like growth factor 1 (IGF-1) secretion in the olfactory bulb
    Title: Activity-dependent IGF-1 exocytosis is controlled by the Ca(2+)-sensor synaptotagmin-10.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SNARE binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables calcium ion binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables clathrin binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylserine binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables phosphatidylserine binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables syntaxin binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcium-ion regulated exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in cellular response to calcium ion IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within exocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of calcium ion-dependent exocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in presynaptic dense core vesicle exocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in presynaptic dense core vesicle exocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of calcium ion-dependent exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in regulation of calcium ion-dependent exocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of dopamine secretion IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in sensory perception of smell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in synaptic vesicle exocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in exocytic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in presynapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
synaptotagmin-10
Names
sytX

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018803.2 → NP_061273.1  synaptotagmin-10

    See identical proteins and their annotated locations for NP_061273.1

    Status: VALIDATED

    Source sequence(s)
    AC124133, BC125634, CJ093642
    Consensus CDS
    CCDS27756.1
    UniProtKB/Swiss-Prot
    Q9R0N4
    UniProtKB/TrEMBL
    Q059J3
    Related
    ENSMUSP00000029441.4, ENSMUST00000029441.4
    Conserved Domains (2) summary
    cd08385
    Location:231 → 356
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08403
    Location:365 → 498
    C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    89657221..89726181 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011245696.2 → XP_011243998.1  synaptotagmin-10 isoform X1

    Conserved Domains (2) summary
    cd08385
    Location:231 → 356
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08403
    Location:365 → 498
    C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10

  2. XM_006521175.3 → XP_006521238.1  synaptotagmin-10 isoform X2

    Conserved Domains (2) summary
    cd08385
    Location:231 → 356
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08403
    Location:365 → 498
    C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10

  3. XM_017316706.3 → XP_017172195.1  synaptotagmin-10 isoform X4

    Conserved Domains (2) summary
    cd08385
    Location:50 → 175
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08403
    Location:184 → 317
    C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10

  4. XM_006521176.4 → XP_006521239.1  synaptotagmin-10 isoform X3

    Conserved Domains (2) summary
    cd08385
    Location:231 → 356
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    COG5038
    Location:142 → 305
    COG5038; Ca2+-dependent lipid-binding protein, contains C2 domain [General function prediction only]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R0N4.1 GenPept UniProtKB/Swiss-Prot:Q9R0N4

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