Syt7 synaptotagmin VII [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Syt7provided by MGI
Official Full Name: synaptotagmin VIIprovided by MGI
Primary source: MGI:MGI:1859545
See related: Ensembl:ENSMUSG00000024743 AllianceGenome:MGI:1859545
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: B230112P13Rik
Summary: Enables SNARE binding activity; calmodulin binding activity; and phospholipid binding activity. Involved in several processes, including calcium-ion regulated exocytosis; regulation of secretion by cell; and regulation of vesicle-mediated transport. Acts upstream of or within plasma membrane repair. Located in several cellular components, including GABA-ergic synapse; cytoplasmic vesicle; and presynaptic membrane. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human SYT7 (synaptotagmin 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cortex adult (RPKM 37.8), frontal lobe adult (RPKM 34.9) and 13 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 19; 19 A

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (10366142..10430545)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (10388802..10453181)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Synaptotagmins 1 and 7 Play Complementary Roles in Somatodendritic Dopamine Release.
Title: Synaptotagmins 1 and 7 Play Complementary Roles in Somatodendritic Dopamine Release.
Effects and Mechanisms of Synaptotagmin-7 in the Hippocampus on Cognitive Impairment in Aging Mice.
Title: Effects and Mechanisms of Synaptotagmin-7 in the Hippocampus on Cognitive Impairment in Aging Mice.
Introduction of synaptotagmin 7 promotes facilitation at the climbing fiber to Purkinje cell synapse.
Title: Introduction of synaptotagmin 7 promotes facilitation at the climbing fiber to Purkinje cell synapse.
Neuromodulator release in neurons requires two functionally redundant calcium sensors.
Title: Neuromodulator release in neurons requires two functionally redundant calcium sensors.
Synaptotagmin-7-mediated activation of spontaneous NMDAR currents is disrupted in bipolar disorder susceptibility variants.
Title: Synaptotagmin-7-mediated activation of spontaneous NMDAR currents is disrupted in bipolar disorder susceptibility variants.
Synaptotagmin 7 is targeted to the axonal plasma membrane through gamma-secretase processing to promote synaptic vesicle docking in mouse hippocampal neurons.
Title: Synaptotagmin 7 is targeted to the axonal plasma membrane through γ-secretase processing to promote synaptic vesicle docking in mouse hippocampal neurons.
Drosophila Synaptotagmin 7 negatively regulates synaptic vesicle release and replenishment in a dosage-dependent manner.
Title: Drosophila Synaptotagmin 7 negatively regulates synaptic vesicle release and replenishment in a dosage-dependent manner.
Synaptotagmin-7 deficiency induces mania-like behavioral abnormalities through attenuating GluN2B activity.
Title: Synaptotagmin-7 deficiency induces mania-like behavioral abnormalities through attenuating GluN2B activity.
Syt7 knockout mice showed nocturnal manic-like and diurnal depressive-like behavioral fluctuations
Title: Synaptotagmin-7 is a key factor for bipolar-like behavioral abnormalities in mice.
Catecholamine (CA) and ATP release from a dense core vesicle is differentially regulated by Syt7. During release of a single vesicle in Syt7 KO versus WT cells, the significantly smaller CA quantal size was sub-quantal, whereas the co-released ATP quantal size remained unchanged as quantal, confirming that CA and ATP co-released from a single vesicle are differentially regulated in Syt7 KO chromaffin cells.
Title: Differential Co-release of Two Neurotransmitters from a Vesicle Fusion Pore in Mammalian Adrenal Chromaffin Cells.

Submit: New GeneRIF Correction See all GeneRIFs (43)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (5)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

NoName (e-PCR)
- UniSTS:489540

Syt7 (e-PCR), detects polymorphism
- UniSTS:507266

AI851541 (e-PCR)
- UniSTS:166125

Homology

Homologs of the Syt7 gene: The Syt7 gene is conserved in human, dog, cow, zebrafish, and frog.
Orthologs from Annotation Pipeline: 449 organisms have orthologs with human gene Syt7
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SNARE binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables SNARE binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium-dependent phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables calcium-dependent phospholipid binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium-dependent phospholipid binding	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	IDA Inferred from Direct Assay more info	PubMed
enables clathrin binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables clathrin binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-4,5-bisphosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylserine binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables phosphatidylserine binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables syntaxin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in calcium ion regulated lysosome exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion regulated lysosome exocytosis	ISO Inferred from Sequence Orthology more info
involved_in calcium ion-regulated exocytosis of neurotransmitter	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in calcium ion-regulated exocytosis of neurotransmitter	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium-dependent activation of synaptic vesicle fusion	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium-dependent activation of synaptic vesicle fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium-ion regulated exocytosis	ISO Inferred from Sequence Orthology more info
involved_in cellular response to calcium ion	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within exocytosis	IEA Inferred from Electronic Annotation more info
involved_in exocytosis	IEA Inferred from Electronic Annotation more info
involved_in phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phagosome-lysosome fusion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within plasma membrane repair	IDA Inferred from Direct Assay more info	PubMed
involved_in plasma membrane repair	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium ion-dependent exocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of bone remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of calcium ion-dependent exocytosis	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in regulation of calcium ion-dependent exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of calcium ion-dependent exocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of dopamine secretion	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in regulation of dopamine secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of glucagon secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic vesicle endocytosis	ISO Inferred from Sequence Orthology more info
involved_in short-term synaptic potentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in short-term synaptic potentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle recycling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle fusion	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in vesicle-mediated cholesterol transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in GABA-ergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in axon terminus	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dense core granule	ISO Inferred from Sequence Orthology more info
located_in early phagosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in hippocampal mossy fiber to CA3 synapse	ISO Inferred from Sequence Orthology more info
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info	PubMed
is_active_in synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in synaptic vesicle	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: synaptotagmin-7

Names: sytVII

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001373944.1 → NP_001360873.1 synaptotagmin-7 isoform 4

Status: VALIDATED

Source sequence(s)

AC124169

Consensus CDS

CCDS89341.1

UniProtKB/TrEMBL

A0A2C9F2C1

Related

ENSMUSP00000076234.5, ENSMUST00000076968.11

Conserved Domains (2) summary

cd08386
Location:343 → 467

C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7

cd08405
Location:475 → 610

C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
NM_018801.3 → NP_061271.1 synaptotagmin-7 isoform alpha

See identical proteins and their annotated locations for NP_061271.1

Status: VALIDATED

Source sequence(s)

AC124169

Consensus CDS

CCDS29575.1

UniProtKB/Swiss-Prot

Q8CF96, Q9R0N7

UniProtKB/TrEMBL

A0A6P5P2V4

Related

ENSMUSP00000073560.5, ENSMUST00000073899.6

Conserved Domains (2) summary

cd08386
Location:135 → 259

C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7

cd08405
Location:267 → 402

C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
NM_173067.3 → NP_775090.1 synaptotagmin-7 isoform beta

See identical proteins and their annotated locations for NP_775090.1

Status: VALIDATED

Source sequence(s)

AC124169

Consensus CDS

CCDS29576.1

UniProtKB/Swiss-Prot

Q9R0N7

UniProtKB/TrEMBL

A0A6P7QI21

Related

ENSMUSP00000153482.2, ENSMUST00000223586.2

Conserved Domains (2) summary

cd08386
Location:179 → 303

C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7

cd08405
Location:311 → 446

C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
NM_173068.2 → NP_775091.2 synaptotagmin-7 isoform gamma

Status: VALIDATED

Source sequence(s)

AC124169

Consensus CDS

CCDS50388.1

UniProtKB/Swiss-Prot

Q9R0N7

Related

ENSMUSP00000153132.3, ENSMUST00000224135.3

Conserved Domains (2) summary

cd08386
Location:299 → 423

C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7

cd08405
Location:431 → 566

C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

10366142..10430545

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006527204.5 → XP_006527267.1 synaptotagmin-7 isoform X2

UniProtKB/TrEMBL

A0A498WGM0

Related

ENSMUSP00000127973.3, ENSMUST00000169121.9

Conserved Domains (3) summary

cd08386
Location:419 → 543

C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7

cd08405
Location:551 → 686

C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7

PHA03307
Location:106 → 311

PHA03307; transcriptional regulator ICP4; Provisional
XM_030250995.2 → XP_030106855.1 synaptotagmin-7 isoform X5

UniProtKB/TrEMBL

A0A494BB44

Related

ENSMUSP00000158359.2, ENSMUST00000235784.2

Conserved Domains (3) summary

cd08386
Location:375 → 499

C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7

cd08405
Location:507 → 642

C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7

PHA03307
Location:100 → 267

PHA03307; transcriptional regulator ICP4; Provisional
XM_030250997.2 → XP_030106857.1 synaptotagmin-7 isoform X9

Conserved Domains (2) summary

cd08386
Location:242 → 366

C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7

cd08405
Location:374 → 509

C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
XM_030250994.1 → XP_030106854.1 synaptotagmin-7 isoform X1

Conserved Domains (3) summary

cd08386
Location:451 → 575

C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7

cd08405
Location:583 → 718

C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7

PHA03307
Location:138 → 343

PHA03307; transcriptional regulator ICP4; Provisional
XM_036161637.1 → XP_036017530.1 synaptotagmin-7 isoform X4

Conserved Domains (2) summary

cd08386
Location:375 → 499

C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7

cd08405
Location:507 → 642

C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
XM_017318255.1 → XP_017173744.1 synaptotagmin-7 isoform X10

Conserved Domains (2) summary

cd08386
Location:211 → 335

C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7

cd08405
Location:343 → 478

C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
XM_017318252.1 → XP_017173741.1 synaptotagmin-7 isoform X3

Conserved Domains (2) summary

cd08386
Location:407 → 531

C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7

cd08405
Location:539 → 674

C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
XM_017318253.1 → XP_017173742.1 synaptotagmin-7 isoform X7

Conserved Domains (2) summary

cd08386
Location:331 → 455

C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7

cd08405
Location:463 → 598

C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
XM_017318257.1 → XP_017173746.1 synaptotagmin-7 isoform X11

Conserved Domains (2) summary

cd08386
Location:167 → 291

C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7

cd08405
Location:299 → 434

C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
XM_036161638.1 → XP_036017531.1 synaptotagmin-7 isoform X6

Conserved Domains (3) summary

cd08386
Location:366 → 490

C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7

cd08405
Location:498 → 633

C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7

PHA03307
Location:91 → 258

PHA03307; transcriptional regulator ICP4; Provisional
XM_030250996.2 → XP_030106856.1 synaptotagmin-7 isoform X8

Conserved Domains (2) summary

cd08386
Location:300 → 424

C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7

cd08405
Location:432 → 567

C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7