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Syt7 synaptotagmin VII [ Mus musculus (house mouse) ]

Gene ID: 54525, updated on 18-Jun-2024

Summary

Official Symbol
Syt7provided by MGI
Official Full Name
synaptotagmin VIIprovided by MGI
Primary source
MGI:MGI:1859545
See related
Ensembl:ENSMUSG00000024743 AllianceGenome:MGI:1859545
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B230112P13Rik
Summary
Enables SNARE binding activity; calmodulin binding activity; and phospholipid binding activity. Involved in several processes, including calcium-ion regulated exocytosis; regulation of secretion by cell; and regulation of vesicle-mediated transport. Acts upstream of or within plasma membrane repair. Located in several cellular components, including GABA-ergic synapse; cytoplasmic vesicle; and presynaptic membrane. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human SYT7 (synaptotagmin 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 37.8), frontal lobe adult (RPKM 34.9) and 13 other tissues See more
Orthologs
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Genomic context

See Syt7 in Genome Data Viewer
Location:
19 A; 19 6.58 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (10366142..10430545)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (10388802..10453181)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene diacylglycerol lipase, alpha Neighboring gene predicted gene, 30042 Neighboring gene predicted gene, 30263 Neighboring gene leucine rich repeat containing 10B Neighboring gene stabilizer of axonemal microtubules 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables SNARE binding IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium-dependent phospholipid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium-dependent phospholipid binding ISO
Inferred from Sequence Orthology
more info
 
enables calmodulin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables clathrin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables clathrin binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol-4,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylserine binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphatidylserine binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables syntaxin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in calcium ion regulated lysosome exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcium ion regulated lysosome exocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium ion-regulated exocytosis of neurotransmitter IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in calcium ion-regulated exocytosis of neurotransmitter IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcium-dependent activation of synaptic vesicle fusion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in calcium-dependent activation of synaptic vesicle fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcium-ion regulated exocytosis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within exocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in phagocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phagosome-lysosome fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within plasma membrane repair IDA
Inferred from Direct Assay
more info
PubMed 
involved_in plasma membrane repair ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of calcium ion-dependent exocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of bone remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of calcium ion-dependent exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of calcium ion-dependent exocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of dopamine secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of glucagon secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of phagocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of synaptic vesicle endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in short-term synaptic potentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in short-term synaptic potentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synaptic vesicle recycling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in vesicle-mediated cholesterol transport IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in GABA-ergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in axon terminus IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in dense core granule ISO
Inferred from Sequence Orthology
more info
 
located_in early phagosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in hippocampal mossy fiber to CA3 synapse ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in peroxisome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in synaptic vesicle IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
synaptotagmin-7
Names
sytVII

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001373944.1NP_001360873.1  synaptotagmin-7 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC124169
    Consensus CDS
    CCDS89341.1
    UniProtKB/TrEMBL
    A0A2C9F2C1
    Related
    ENSMUSP00000076234.5, ENSMUST00000076968.11
    Conserved Domains (2) summary
    cd08386
    Location:343467
    C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
    cd08405
    Location:475610
    C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
  2. NM_018801.3NP_061271.1  synaptotagmin-7 isoform alpha

    See identical proteins and their annotated locations for NP_061271.1

    Status: VALIDATED

    Source sequence(s)
    AC124169
    Consensus CDS
    CCDS29575.1
    UniProtKB/Swiss-Prot
    A4QPF1, E9PZA8, Q0D2K7, Q8CF95, Q8CF96, Q9R0N7
    UniProtKB/TrEMBL
    A0A494B9N4
    Related
    ENSMUSP00000073560.5, ENSMUST00000073899.6
    Conserved Domains (2) summary
    cd08386
    Location:135259
    C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
    cd08405
    Location:267402
    C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
  3. NM_173067.3NP_775090.1  synaptotagmin-7 isoform beta

    See identical proteins and their annotated locations for NP_775090.1

    Status: VALIDATED

    Source sequence(s)
    AC124169
    Consensus CDS
    CCDS29576.1
    UniProtKB/TrEMBL
    A0A494B9N4
    Related
    ENSMUSP00000153482.2, ENSMUST00000223586.2
    Conserved Domains (2) summary
    cd08386
    Location:179303
    C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
    cd08405
    Location:311446
    C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
  4. NM_173068.2NP_775091.2  synaptotagmin-7 isoform gamma

    Status: VALIDATED

    Source sequence(s)
    AC124169
    Consensus CDS
    CCDS50388.1
    UniProtKB/Swiss-Prot
    Q9R0N7
    Related
    ENSMUSP00000153132.3, ENSMUST00000224135.3
    Conserved Domains (2) summary
    cd08386
    Location:299423
    C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
    cd08405
    Location:431566
    C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    10366142..10430545
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527204.5XP_006527267.1  synaptotagmin-7 isoform X2

    UniProtKB/TrEMBL
    A0A498WGM0
    Related
    ENSMUSP00000127973.3, ENSMUST00000169121.9
    Conserved Domains (3) summary
    cd08386
    Location:419543
    C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
    cd08405
    Location:551686
    C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
    PHA03307
    Location:106311
    PHA03307; transcriptional regulator ICP4; Provisional
  2. XM_030250995.2XP_030106855.1  synaptotagmin-7 isoform X5

    UniProtKB/TrEMBL
    A0A494B991, A0A494BB44
    Related
    ENSMUSP00000158359.2, ENSMUST00000235784.2
    Conserved Domains (3) summary
    cd08386
    Location:375499
    C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
    cd08405
    Location:507642
    C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
    PHA03307
    Location:100267
    PHA03307; transcriptional regulator ICP4; Provisional
  3. XM_030250997.2XP_030106857.1  synaptotagmin-7 isoform X9

    Conserved Domains (2) summary
    cd08386
    Location:242366
    C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
    cd08405
    Location:374509
    C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
  4. XM_030250994.1XP_030106854.1  synaptotagmin-7 isoform X1

    Conserved Domains (3) summary
    cd08386
    Location:451575
    C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
    cd08405
    Location:583718
    C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
    PHA03307
    Location:138343
    PHA03307; transcriptional regulator ICP4; Provisional
  5. XM_036161637.1XP_036017530.1  synaptotagmin-7 isoform X4

    Conserved Domains (2) summary
    cd08386
    Location:375499
    C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
    cd08405
    Location:507642
    C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
  6. XM_017318255.1XP_017173744.1  synaptotagmin-7 isoform X10

    UniProtKB/TrEMBL
    A0A494B9N4
    Conserved Domains (2) summary
    cd08386
    Location:211335
    C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
    cd08405
    Location:343478
    C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
  7. XM_017318252.1XP_017173741.1  synaptotagmin-7 isoform X3

    Conserved Domains (2) summary
    cd08386
    Location:407531
    C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
    cd08405
    Location:539674
    C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
  8. XM_017318253.1XP_017173742.1  synaptotagmin-7 isoform X7

    Conserved Domains (2) summary
    cd08386
    Location:331455
    C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
    cd08405
    Location:463598
    C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
  9. XM_017318257.1XP_017173746.1  synaptotagmin-7 isoform X11

    UniProtKB/TrEMBL
    A0A494B9N4
    Conserved Domains (2) summary
    cd08386
    Location:167291
    C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
    cd08405
    Location:299434
    C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
  10. XM_036161638.1XP_036017531.1  synaptotagmin-7 isoform X6

    Conserved Domains (3) summary
    cd08386
    Location:366490
    C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
    cd08405
    Location:498633
    C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
    PHA03307
    Location:91258
    PHA03307; transcriptional regulator ICP4; Provisional
  11. XM_030250996.2XP_030106856.1  synaptotagmin-7 isoform X8

    Conserved Domains (2) summary
    cd08386
    Location:300424
    C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
    cd08405
    Location:432567
    C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7