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Apbb1ip amyloid beta precursor protein binding family B member 1 interacting protein [ Mus musculus (house mouse) ]

Gene ID: 54519, updated on 27-Nov-2024

Summary

Official Symbol
Apbb1ipprovided by MGI
Official Full Name
amyloid beta precursor protein binding family B member 1 interacting proteinprovided by MGI
Primary source
MGI:MGI:1861354
See related
Ensembl:ENSMUSG00000026786 AllianceGenome:MGI:1861354
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Prp48; 9930118P07Rik
Summary
Acts upstream of or within T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell and positive regulation of cell adhesion. Located in cytosol and plasma membrane. Part of T cell receptor complex. Is expressed in several structures, including brain; genitourinary system; hemolymphoid system; liver; and molar. Orthologous to human APBB1IP (amyloid beta precursor protein binding family B member 1 interacting protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in thymus adult (RPKM 9.0), spleen adult (RPKM 6.8) and 15 other tissues See more
Orthologs
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Genomic context

See Apbb1ip in Genome Data Viewer
Location:
2 A3; 2 15.15 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (22645983..22765671)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (22755971..22875653)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene glutamic acid decarboxylase 2 Neighboring gene microRNA 3967 Neighboring gene STARR-seq mESC enhancer starr_03915 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 3 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E4417 Neighboring gene STARR-seq mESC enhancer starr_03917 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:22661206-22661359 Neighboring gene STARR-positive B cell enhancer ABC_E7796 Neighboring gene STARR-seq mESC enhancer starr_03918 Neighboring gene STARR-seq mESC enhancer starr_03919 Neighboring gene STARR-seq mESC enhancer starr_03920 Neighboring gene STARR-seq mESC enhancer starr_03922 Neighboring gene predicted gene, 52503 Neighboring gene prenyl (solanesyl) diphosphate synthase, subunit 1 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene abl interactor 1 Neighboring gene STARR-seq mESC enhancer starr_03923 Neighboring gene predicted gene, 52502

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (4)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of T cell receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
 
located_in lamellipodium IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
amyloid beta A4 precursor protein-binding family B member 1-interacting protein
Names
APBB1-interacting protein 1
PREL-1
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
proline-rich EVH1 ligand 1
proline-rich protein 48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019456.2NP_062329.2  amyloid beta A4 precursor protein-binding family B member 1-interacting protein

    See identical proteins and their annotated locations for NP_062329.2

    Status: VALIDATED

    Source sequence(s)
    AK021331, AK041552, AK089987, BB638237, CT030013
    Consensus CDS
    CCDS38056.1
    UniProtKB/Swiss-Prot
    O35329, Q8BRU0, Q8R5A3, Q99KV8
    UniProtKB/TrEMBL
    B1AYC9
    Related
    ENSMUSP00000014290.9, ENSMUST00000014290.15
    Conserved Domains (2) summary
    cd01259
    Location:310431
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16137
    Location:186267
    RA_MRL_RIAM; Ras-associating (RA) domain found in Rap1-GTP-interacting adapter molecule (RIAM)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    22645983..22765671
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498186.4XP_006498249.1  amyloid beta A4 precursor protein-binding family B member 1-interacting protein isoform X1

    See identical proteins and their annotated locations for XP_006498249.1

    UniProtKB/Swiss-Prot
    O35329, Q8BRU0, Q8R5A3, Q99KV8
    UniProtKB/TrEMBL
    B1AYC9
    Conserved Domains (2) summary
    cd01259
    Location:310431
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16137
    Location:186267
    RA_MRL_RIAM; Ras-associating (RA) domain found in Rap1-GTP-interacting adapter molecule (RIAM)
  2. XM_006498187.2XP_006498250.1  amyloid beta A4 precursor protein-binding family B member 1-interacting protein isoform X2

    Conserved Domains (2) summary
    cd01259
    Location:243364
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16137
    Location:119200
    RA_MRL_RIAM; Ras-associating (RA) domain found in Rap1-GTP-interacting adapter molecule (RIAM)