U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

APBB1IP amyloid beta precursor protein binding family B member 1 interacting protein [ Homo sapiens (human) ]

Gene ID: 54518, updated on 7-Apr-2025

Summary

Go to the top of the page Help
Official Symbol
APBB1IPprovided by HGNC
Official Full Name
amyloid beta precursor protein binding family B member 1 interacting proteinprovided by HGNC
Primary source
HGNC:HGNC:17379
See related
Ensembl:ENSG00000077420 MIM:609036; AllianceGenome:HGNC:17379
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RIAM; INAG1; PREL1; RARP1
Summary
Predicted to be involved in signal transduction. Predicted to act upstream of or within T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell and positive regulation of cell adhesion. Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]
Expression
Broad expression in appendix (RPKM 24.2), spleen (RPKM 22.5) and 16 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See APBB1IP in Genome Data Viewer
Location:
10p12.1
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (26438341..26567803)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (26462982..26592541)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (26727270..26856732)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene NANOG hESC enhancer GRCh37_chr10:26263803-26264349 Neighboring gene myosin IIIA Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:26289384-26290583 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:26290901-26292100 Neighboring gene NANOG hESC enhancer GRCh37_chr10:26488725-26489248 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr10:26502717-26503284 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:26503285-26503850 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:26503851-26504417 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:26507027-26507655 Neighboring gene glutamate decarboxylase 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3164 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3165 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3167 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:26726587-26727116 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2235 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3168 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:26778915-26779063 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2236 Neighboring gene RNA, 5S ribosomal pseudogene 307 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3169 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3170 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:26868178-26868678 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:26871445-26871944 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:26877727-26878226 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:26882505-26883048 Neighboring gene long intergenic non-protein coding RNA 3028 Neighboring gene family with sequence similarity 238 member A

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Structural, biochemical, and functional properties of the Rap1-Interacting Adaptor Molecule (RIAM). Sari-Ak D, et al. Biomed J, 2022 Apr. PMID 34601137, Free PMC Article
  2. Phosphorylation of RIAM by src promotes integrin activation by unmasking the PH domain of RIAM. Cho EA, et al. Structure, 2021 Apr 1. PMID 33275877, Free PMC Article
  3. Rap1-GTP-interacting adaptor molecule (RIAM) protein controls invasion and growth of melanoma cells. Hernández-Varas P, et al. J Biol Chem, 2011 May 27. PMID 21454517, Free PMC Article
  4. Rap1-interacting adapter molecule (RIAM) associates with the plasma membrane via a proximity detector. Wynne JP, et al. J Cell Biol, 2012 Oct 15. PMID 23045549, Free PMC Article
  5. RIAM (Rap1-interacting adaptor molecule) regulates complement-dependent phagocytosis. Medraño-Fernandez I, et al. Cell Mol Life Sci, 2013 Jul. PMID 23420480, Free PMC Article

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression of the phagocytic receptors alphaMbeta2 and alphaXbeta2 is controlled by RIAM, VASP and Vinculin in neutrophil-differentiated HL-60 cells.
    Title: Expression of the phagocytic receptors α(M)β(2) and α(X)β(2) is controlled by RIAM, VASP and Vinculin in neutrophil-differentiated HL-60 cells.
  2. Structural, biochemical, and functional properties of the Rap1-Interacting Adaptor Molecule (RIAM).
    Title: Structural, biochemical, and functional properties of the Rap1-Interacting Adaptor Molecule (RIAM).
  3. Phosphorylation of RIAM by src promotes integrin activation by unmasking the PH domain of RIAM.
    Title: Phosphorylation of RIAM by src promotes integrin activation by unmasking the PH domain of RIAM.
  4. RIAM-VASP Module Relays Integrin Complement Receptors in Outside-In Signaling Driving Particle Engulfment.
    Title: RIAM-VASP Module Relays Integrin Complement Receptors in Outside-In Signaling Driving Particle Engulfment.
  5. Talin dissociates from RIAM and associates to vinculin sequentially in response to the actomyosin force.
    Title: Talin dissociates from RIAM and associates to vinculin sequentially in response to the actomyosin force.
  6. We solved the crystal structure of IN-RA-PH to a resolution of 2.4-A. The structure reveals that the IN segment associates with the RA segment and thereby suppresses RIAM:RAP1 association. This autoinhibitory configuration of RIAM can be released by phosphorylation at Tyr45 in the IN segment.
    Title: Molecular basis for autoinhibition of RIAM regulated by FAK in integrin activation.
  7. Authors provide an overview of the structure and interactions of RIAM and discuss the implications of RIAM functions in innate and adaptive immunity and cancer. [Review]
    Title: The adaptor molecule RIAM integrates signaling events critical for integrin-mediated control of immune function and cancer progression.
  8. The Rap1-RIAM-talin axis of integrin activation and blood cell function
    Title: The Rap1-RIAM-talin axis of integrin activation and blood cell function.
  9. Disruption of the RIAM/lamellipodin-integrin-talin complex markedly impairs cell migration.
    Title: A RIAM/lamellipodin-talin-integrin complex forms the tip of sticky fingers that guide cell migration.
  10. RIAM is a critical component of the phagocytosis machinery downstream of Rap1 and mediates its function by recruiting talin to the phagocytic complement receptors.
    Title: RIAM (Rap1-interacting adaptor molecule) regulates complement-dependent phagocytosis.
Submit: New GeneRIF Correction See all GeneRIFs (19)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study of inflammatory biomarker changes in response to fenofibrate treatment in the Genetics of Lipid Lowering Drug and Diet Network.
EBI GWAS Catalog
Genomic association analysis identifies multiple loci influencing antihypertensive response to an angiotensin II receptor blocker.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of T cell receptor complex IEA
Inferred from Electronic Annotation
more info
  
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
  
located_in lamellipodium IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
amyloid beta A4 precursor protein-binding family B member 1-interacting protein
Names
APBB1-interacting protein 1
MLLT10/APBB1IP reciprocal fusion
MLLT10/APBB1IP reciprocal fusion protein
PREL-1
RARP-1
Rap1-GTP-interacting adaptor molecule
Rap1-interacting adaptor molecule
proline rich EVH1 ligand 1
proline-rich protein 73
rap1-GTP-interacting adapter molecule
retinoic acid-responsive proline-rich protein 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019043.4 → NP_061916.3  amyloid beta A4 precursor protein-binding family B member 1-interacting protein

    See identical proteins and their annotated locations for NP_061916.3

    Status: VALIDATED

    Source sequence(s)
    BC054516, BM150270, BM556115
    Consensus CDS
    CCDS31167.1
    UniProtKB/Swiss-Prot
    Q7Z5R6, Q8IWS8, Q8IYL7, Q8IZZ7
    UniProtKB/TrEMBL
    B4E100
    Related
    ENSP00000365411.4, ENST00000376236.9
    Conserved Domains (3) summary
    cd01787
    Location:183 → 261
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd01259
    Location:307 → 428
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam00169
    Location:311 → 419
    PH; PH domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    26438341..26567803
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011519514.3 → XP_011517816.1  amyloid beta A4 precursor protein-binding family B member 1-interacting protein isoform X1

    Conserved Domains (3) summary
    cd01787
    Location:183 → 261
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd01259
    Location:300 → 380
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam00169
    Location:295 → 371
    PH; PH domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    26462982..26592541
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054366128.1 → XP_054222103.1  amyloid beta A4 precursor protein-binding family B member 1-interacting protein isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7Z5R6.1 GenPept UniProtKB/Swiss-Prot:Q7Z5R6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous