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NEURL1B neuralized E3 ubiquitin protein ligase 1B [ Homo sapiens (human) ]

Gene ID: 54492, updated on 13-Mar-2020

Summary

Official Symbol
NEURL1Bprovided by HGNC
Official Full Name
neuralized E3 ubiquitin protein ligase 1Bprovided by HGNC
Primary source
HGNC:HGNC:35422
See related
Ensembl:ENSG00000214357 MIM:615893
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
neur2; NEURL3; RNF67B; hNeur2
Expression
Ubiquitous expression in fat (RPKM 15.4), colon (RPKM 11.9) and 23 other tissues See more
Orthologs

Genomic context

See NEURL1B in Genome Data Viewer
Location:
5q35.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (172641263..172691540)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (172068266..172118543)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377729 Neighboring gene uncharacterized LOC107986478 Neighboring gene translation machinery associated 7 homolog (S. cerevisiae) pseudogene Neighboring gene microRNA 5003 Neighboring gene uncharacterized LOC107986479 Neighboring gene heart enhancer 25 Neighboring gene uncharacterized LOC101928093 Neighboring gene cyclin Q pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association studies and heritability estimates of body mass index related phenotypes in bangladeshi adults.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp761M1511

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin protein ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-dependent endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-dependent endocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
early endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
early endosome ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase NEURL1B
Names
E3 ubiquitin-protein ligase NEURL3
RING-type E3 ubiquitin transferase NEURL1B
neuralized 2 alternative protein
neuralized homolog 1B
neuralized-2
neuralized-like protein 1B
neuralized-like protein 3
NP_001136123.1
NP_001295106.1
NP_001295107.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142651.3NP_001136123.1  E3 ubiquitin-protein ligase NEURL1B isoform hNEUR2

    See identical proteins and their annotated locations for NP_001136123.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (hNEUR2).
    Source sequence(s)
    AC027309, AK026748, AK096661, CN267889, GQ414757, HY104395
    Consensus CDS
    CCDS47342.1
    UniProtKB/Swiss-Prot
    A8MQ27
    Related
    ENSP00000358815.5, ENST00000369800.6
    Conserved Domains (4) summary
    smart00588
    Location:40159
    NEUZ; domain in neuralized proteins
    pfam07177
    Location:41106
    Neuralized; Neuralized
    pfam13920
    Location:499549
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
    cl02614
    Location:40189
    SPRY; SPRY domain
  2. NM_001308177.2NP_001295106.1  E3 ubiquitin-protein ligase NEURL1B isoform hNEUR2-deltaNHR1

    See identical proteins and their annotated locations for NP_001295106.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (hNEUR2-deltaNHR1) that is shorter than isoform hNEUR2.
    Source sequence(s)
    AC027309, AK026748, AK096661, CN267889, GQ414758, HY104395
    Consensus CDS
    CCDS83042.1
    UniProtKB/Swiss-Prot
    A8MQ27
    Related
    ENSP00000430001.1, ENST00000522853.5
    Conserved Domains (3) summary
    smart00588
    Location:97217
    NEUZ; domain in neuralized proteins
    pfam07177
    Location:100165
    Neuralized; Neuralized
    pfam13920
    Location:317367
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
  3. NM_001308178.2NP_001295107.1  E3 ubiquitin-protein ligase NEURL1B isoform hNEUR2-deltaNHR2

    See identical proteins and their annotated locations for NP_001295107.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (hNEUR2-deltaNHR2) that is shorter than isoform hNEUR2.
    Source sequence(s)
    AC027309, AK026748, AK096661, CN267889, GQ414759, HY104395
    Consensus CDS
    CCDS78085.1
    UniProtKB/Swiss-Prot
    A8MQ27
    Related
    ENSP00000429797.1, ENST00000520919.5
    Conserved Domains (2) summary
    pfam07177
    Location:41193
    Neuralized; Neuralized
    cl17238
    Location:262304
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    172641263..172691540
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_015355.3: Suppressed sequence

    Description
    NR_015355.3: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
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