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OTULINL OTU deubiquitinase with linear linkage specificity like [ Homo sapiens (human) ]

Gene ID: 54491, updated on 7-Jun-2020

Summary

Official Symbol
OTULINLprovided by HGNC
Official Full Name
OTU deubiquitinase with linear linkage specificity likeprovided by HGNC
Primary source
HGNC:HGNC:25629
See related
Ensembl:ENSG00000145569
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NET20; FAM105A
Expression
Broad expression in bone marrow (RPKM 12.7), colon (RPKM 9.2) and 21 other tissues See more
Orthologs

Genomic context

See OTULINL in Genome Data Viewer
Location:
5p15.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (14581792..14616180)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (14581891..14616289)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene meiotic recombination hotspot J Neighboring gene dynein axonemal heavy chain 5 Neighboring gene trio Rho guanine nucleotide exchange factor Neighboring gene small nucleolar RNA, C/D box 170 Neighboring gene pleckstrin homology domain containing A1 pseudogene Neighboring gene chaperonin containing TCP1 subunit 6 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11127, FLJ43660

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT ubiquitin binding IDA
Inferred from Direct Assay
more info
PubMed 
NOT ubiquitin-like protein-specific protease activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
NOT protein deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
extrinsic component of endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
inactive ubiquitin thioesterase OTULINL
Names
family with sequence similarity 105 member A
inactive ubiquitin thioesterase FAM105A
protein FAM105A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019018.3NP_061891.1  inactive ubiquitin thioesterase OTULINL

    See identical proteins and their annotated locations for NP_061891.1

    Status: VALIDATED

    Source sequence(s)
    AC010627, AF052146, BC011524, BX342178
    Consensus CDS
    CCDS3884.1
    UniProtKB/Swiss-Prot
    Q9NUU6
    Related
    ENSP00000274217.3, ENST00000274217.4
    Conserved Domains (1) summary
    pfam16218
    Location:89355
    Peptidase_C101; Peptidase family C101

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    14581792..14616180
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514056.2XP_011512358.1  inactive ubiquitin thioesterase OTULINL isoform X1

    Conserved Domains (1) summary
    pfam16218
    Location:1197
    Peptidase_C101; Peptidase family C101

RNA

  1. XR_925623.2 RNA Sequence

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