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Dll4 delta like canonical Notch ligand 4 [ Mus musculus (house mouse) ]

Gene ID: 54485, updated on 15-Jul-2018
Official Symbol
Dll4provided by MGI
Official Full Name
delta like canonical Notch ligand 4provided by MGI
Primary source
MGI:MGI:1859388
See related
Ensembl:ENSMUSG00000027314 Vega:OTTMUSG00000015953
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Delta4
Expression
Broad expression in lung adult (RPKM 41.8), subcutaneous fat pad adult (RPKM 15.0) and 16 other tissues See more
Orthologs
See Dll4 in Genome Data Viewer
Location:
2; 2 E5
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (119325784..119335666)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (119151520..119161402)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein S27 pseudogene Neighboring gene VPS18 CORVET/HOPS core subunit Neighboring gene predicted gene 14207 Neighboring gene ChaC, cation transport regulator 1 Neighboring gene INO80 complex subunit

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
Notch binding IDA
Inferred from Direct Assay
more info
PubMed 
Notch binding IPI
Inferred from Physical Interaction
more info
PubMed 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Notch signaling involved in heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Notch signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
T cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
blood vessel lumenization IMP
Inferred from Mutant Phenotype
more info
PubMed 
blood vessel remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
branching involved in blood vessel morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cardiac atrium morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cardiac ventricle morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell communication IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cellular response to fibroblast growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to vascular endothelial growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
dorsal aorta morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of Notch signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of blood vessel endothelial cell migration IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
nervous system development IEA
Inferred from Electronic Annotation
more info
 
pericardium morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of Notch signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neural precursor cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of neural retina development IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of neurogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to stimulus IEA
Inferred from Electronic Annotation
more info
 
ventral spinal cord interneuron fate commitment ISO
Inferred from Sequence Orthology
more info
 
ventricular trabecula myocardium morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
visual perception IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
delta-like protein 4
Names
delta-like 4
drosophila Delta homolog 4

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019454.3NP_062327.2  delta-like protein 4 precursor

    See identical proteins and their annotated locations for NP_062327.2

    Status: VALIDATED

    Source sequence(s)
    AK052322, AL929318, BC049130
    Consensus CDS
    CCDS16600.1
    UniProtKB/Swiss-Prot
    Q9JI71
    Related
    ENSMUSP00000099575.3, OTTMUSP00000017019, ENSMUST00000102517.3, OTTMUST00000037914
    Conserved Domains (3) summary
    cd00054
    Location:329361
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam01414
    Location:156218
    DSL; Delta serrate ligand
    pfam07657
    Location:2889
    MNNL; N terminus of Notch ligand

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

    Range
    119325784..119335666
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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