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KRT20 keratin 20 [ Homo sapiens (human) ]

Gene ID: 54474, updated on 11-Sep-2019

Summary

Official Symbol
KRT20provided by HGNC
Official Full Name
keratin 20provided by HGNC
Primary source
HGNC:HGNC:20412
See related
Ensembl:ENSG00000171431 MIM:608218
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
K20; CD20; CK20; CK-20; KRT21
Summary
The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This cytokeratin is a major cellular protein of mature enterocytes and goblet cells and is specifically expressed in the gastric and intestinal mucosa. The type I cytokeratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008]
Expression
Biased expression in small intestine (RPKM 435.8), colon (RPKM 405.3) and 3 other tissues See more
Orthologs

Genomic context

See KRT20 in Genome Data Viewer
Location:
17q21.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (40875889..40885242, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (39032141..39041495, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene transmembrane protein 99 (putative) Neighboring gene keratin 10 Neighboring gene uncharacterized LOC105371777 Neighboring gene keratin 12 Neighboring gene uncharacterized LOC107985072 Neighboring gene keratin 23 Neighboring gene keratin 39

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • Keratinization, organism-specific biosystem (from REACTOME)
    Keratinization, organism-specific biosystemKeratins are the major structural protein of vertebrate epidermis, constituting up to 85% of a fully differentiated keratinocyte (Fuchs 1995). Keratins belong to a superfamily of intermediate filamen...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC35423

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of cytoskeleton NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cellular response to starvation IEA
Inferred from Electronic Annotation
more info
 
cornification TAS
Traceable Author Statement
more info
 
intermediate filament organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
keratinization TAS
Traceable Author Statement
more info
 
regulation of protein secretion IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
intermediate filament NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
keratin, type I cytoskeletal 20
Names
cytokeratin 20
keratin 20, type I
protein IT

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012286.1 RefSeqGene

    Range
    4986..14339
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_019010.3NP_061883.1  keratin, type I cytoskeletal 20

    See identical proteins and their annotated locations for NP_061883.1

    Status: REVIEWED

    Source sequence(s)
    BC031559, DA426874, DB242980
    Consensus CDS
    CCDS11379.1
    UniProtKB/Swiss-Prot
    P35900
    Related
    ENSP00000167588.3, ENST00000167588.3
    Conserved Domains (1) summary
    pfam00038
    Location:69380
    Filament; Intermediate filament protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    40875889..40885242 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NW_003871091.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    25157..34510 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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