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ZFAND6 zinc finger AN1-type containing 6 [ Homo sapiens (human) ]

Gene ID: 54469, updated on 7-Jun-2020

Summary

Official Symbol
ZFAND6provided by HGNC
Official Full Name
zinc finger AN1-type containing 6provided by HGNC
Primary source
HGNC:HGNC:30164
See related
Ensembl:ENSG00000086666 MIM:610183
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AWP1; ZA20D3; ZFAND5B
Expression
Ubiquitous expression in testis (RPKM 50.8), thyroid (RPKM 41.4) and 25 other tissues See more
Orthologs

Genomic context

See ZFAND6 in Genome Data Viewer
Location:
15q25.1
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (80059568..80138393)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (80351910..80430735)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ribonucleotide reductase regulatory subunit M2 pseudogene Neighboring gene BCL2 related protein A1 Neighboring gene Sharpr-MPRA regulatory region 12283 Neighboring gene fumarylacetoacetate hydrolase Neighboring gene cortexin domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
molecular_function ND
No biological Data available
more info
 
polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
polyubiquitin modification-dependent protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cellular response to tumor necrosis factor IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein targeting to peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein targeting to peroxisome ISS
Inferred from Sequence or Structural Similarity
more info
 
protein targeting to peroxisome TAS
Traceable Author Statement
more info
 
regulation of I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
AN1-type zinc finger protein 6
Names
protein associated with PRK1
zinc finger, A20 domain containing 3
zinc finger, AN1-type domain 6

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242911.1NP_001229840.1  AN1-type zinc finger protein 6 isoform a

    See identical proteins and their annotated locations for NP_001229840.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-7 all encode isoform a.
    Source sequence(s)
    AC092701, AL136598, AW571396, DB050060
    Consensus CDS
    CCDS10313.1
    UniProtKB/Swiss-Prot
    Q6FIF0
    Related
    ENSP00000454137.1, ENST00000558494.5
    Conserved Domains (2) summary
    smart00154
    Location:149186
    ZnF_AN1; AN1-like Zinc finger
    pfam01754
    Location:1235
    zf-A20; A20-like zinc finger
  2. NM_001242912.1NP_001229841.1  AN1-type zinc finger protein 6 isoform a

    See identical proteins and their annotated locations for NP_001229841.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-7 all encode isoform a.
    Source sequence(s)
    AC092701, AW571396, BX363429, DB050060
    Consensus CDS
    CCDS10313.1
    UniProtKB/Swiss-Prot
    Q6FIF0
    Related
    ENSP00000479071.1, ENST00000613266.4
    Conserved Domains (2) summary
    smart00154
    Location:149186
    ZnF_AN1; AN1-like Zinc finger
    pfam01754
    Location:1235
    zf-A20; A20-like zinc finger
  3. NM_001242913.1NP_001229842.1  AN1-type zinc finger protein 6 isoform a

    See identical proteins and their annotated locations for NP_001229842.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-7 all encode isoform a.
    Source sequence(s)
    AC092701, AW571396, CN428457
    Consensus CDS
    CCDS10313.1
    UniProtKB/Swiss-Prot
    Q6FIF0
    Conserved Domains (2) summary
    smart00154
    Location:149186
    ZnF_AN1; AN1-like Zinc finger
    pfam01754
    Location:1235
    zf-A20; A20-like zinc finger
  4. NM_001242914.1NP_001229843.1  AN1-type zinc finger protein 6 isoform a

    See identical proteins and their annotated locations for NP_001229843.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1-7 all encode isoform a.
    Source sequence(s)
    AC092701, AW571396, BG720174, BI562073
    Consensus CDS
    CCDS10313.1
    UniProtKB/Swiss-Prot
    Q6FIF0
    Related
    ENSP00000484971.1, ENST00000618205.4
    Conserved Domains (2) summary
    smart00154
    Location:149186
    ZnF_AN1; AN1-like Zinc finger
    pfam01754
    Location:1235
    zf-A20; A20-like zinc finger
  5. NM_001242915.1NP_001229844.1  AN1-type zinc finger protein 6 isoform a

    See identical proteins and their annotated locations for NP_001229844.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1-7 all encode isoform a.
    Source sequence(s)
    AF261138, AW571396, DA091136
    Consensus CDS
    CCDS10313.1
    UniProtKB/Swiss-Prot
    Q6FIF0
    Related
    ENSP00000453291.1, ENST00000559835.5
    Conserved Domains (2) summary
    smart00154
    Location:149186
    ZnF_AN1; AN1-like Zinc finger
    pfam01754
    Location:1235
    zf-A20; A20-like zinc finger
  6. NM_001242916.1NP_001229845.1  AN1-type zinc finger protein 6 isoform a

    See identical proteins and their annotated locations for NP_001229845.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1-7 all encode isoform a.
    Source sequence(s)
    AC092701, AW571396, DA091136, DR762914
    Consensus CDS
    CCDS10313.1
    UniProtKB/Swiss-Prot
    Q6FIF0
    Related
    ENSP00000453709.1, ENST00000559775.5
    Conserved Domains (2) summary
    smart00154
    Location:149186
    ZnF_AN1; AN1-like Zinc finger
    pfam01754
    Location:1235
    zf-A20; A20-like zinc finger
  7. NM_001242917.1NP_001229846.1  AN1-type zinc finger protein 6 isoform b

    See identical proteins and their annotated locations for NP_001229846.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AC092701, AF061739, AW571396, DB050060
    Consensus CDS
    CCDS58395.1
    UniProtKB/Swiss-Prot
    Q6FIF0
    Related
    ENSP00000454152.1, ENST00000559157.5
    Conserved Domains (3) summary
    smart00154
    Location:137174
    ZnF_AN1; AN1-like Zinc finger
    pfam01754
    Location:1235
    zf-A20; A20-like zinc finger
    pfam06484
    Location:25130
    Ten_N; Teneurin Intracellular Region
  8. NM_001242918.1NP_001229847.1  AN1-type zinc finger protein 6 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AC092701, AW571396, BP231220, DB050060
    Related
    ENSP00000454273.1, ENST00000564367.5
    Conserved Domains (3) summary
    pfam01754
    Location:1235
    zf-A20; A20-like zinc finger
    pfam06484
    Location:25117
    Ten_N; Teneurin Intracellular Region
    cl01438
    Location:118148
    zf-AN1; AN1-like Zinc finger
  9. NM_001242919.1NP_001229848.1  AN1-type zinc finger protein 6 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR and uses two alternate in-frame splice sites in the central coding region, compared to variant 1. The encoded isoform (d) is shorter than isoform a.
    Source sequence(s)
    AC092701, AW571396, BP234517
    Conserved Domains (2) summary
    smart00154
    Location:122159
    ZnF_AN1; AN1-like Zinc finger
    pfam01754
    Location:1235
    zf-A20; A20-like zinc finger
  10. NM_019006.4NP_061879.2  AN1-type zinc finger protein 6 isoform a

    See identical proteins and their annotated locations for NP_061879.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1-7 all encode isoform a.
    Source sequence(s)
    AW571396, BC005283, DB050060
    Consensus CDS
    CCDS10313.1
    UniProtKB/Swiss-Prot
    Q6FIF0
    Related
    ENSP00000261749.6, ENST00000261749.11
    Conserved Domains (2) summary
    smart00154
    Location:149186
    ZnF_AN1; AN1-like Zinc finger
    pfam01754
    Location:1235
    zf-A20; A20-like zinc finger

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    80059568..80138393
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449962.1XP_024305730.1  AN1-type zinc finger protein 6 isoform X1

    Conserved Domains (2) summary
    smart00154
    Location:149186
    ZnF_AN1; AN1-like Zinc finger
    pfam01754
    Location:1235
    zf-A20; A20-like zinc finger
  2. XM_024449956.1XP_024305724.1  AN1-type zinc finger protein 6 isoform X1

    Conserved Domains (2) summary
    smart00154
    Location:149186
    ZnF_AN1; AN1-like Zinc finger
    pfam01754
    Location:1235
    zf-A20; A20-like zinc finger
  3. XM_024449963.1XP_024305731.1  AN1-type zinc finger protein 6 isoform X1

    Conserved Domains (2) summary
    smart00154
    Location:149186
    ZnF_AN1; AN1-like Zinc finger
    pfam01754
    Location:1235
    zf-A20; A20-like zinc finger
  4. XM_024449959.1XP_024305727.1  AN1-type zinc finger protein 6 isoform X1

    Conserved Domains (2) summary
    smart00154
    Location:149186
    ZnF_AN1; AN1-like Zinc finger
    pfam01754
    Location:1235
    zf-A20; A20-like zinc finger
  5. XM_024449958.1XP_024305726.1  AN1-type zinc finger protein 6 isoform X1

    Conserved Domains (2) summary
    smart00154
    Location:149186
    ZnF_AN1; AN1-like Zinc finger
    pfam01754
    Location:1235
    zf-A20; A20-like zinc finger
  6. XM_024449961.1XP_024305729.1  AN1-type zinc finger protein 6 isoform X1

    Conserved Domains (2) summary
    smart00154
    Location:149186
    ZnF_AN1; AN1-like Zinc finger
    pfam01754
    Location:1235
    zf-A20; A20-like zinc finger
  7. XM_024449960.1XP_024305728.1  AN1-type zinc finger protein 6 isoform X1

    Conserved Domains (2) summary
    smart00154
    Location:149186
    ZnF_AN1; AN1-like Zinc finger
    pfam01754
    Location:1235
    zf-A20; A20-like zinc finger
  8. XM_011521684.2XP_011519986.1  AN1-type zinc finger protein 6 isoform X1

    See identical proteins and their annotated locations for XP_011519986.1

    UniProtKB/Swiss-Prot
    Q6FIF0
    Conserved Domains (2) summary
    smart00154
    Location:149186
    ZnF_AN1; AN1-like Zinc finger
    pfam01754
    Location:1235
    zf-A20; A20-like zinc finger
  9. XM_024449957.1XP_024305725.1  AN1-type zinc finger protein 6 isoform X1

    Related
    ENSP00000478129.1, ENST00000616533.4
    Conserved Domains (2) summary
    smart00154
    Location:149186
    ZnF_AN1; AN1-like Zinc finger
    pfam01754
    Location:1235
    zf-A20; A20-like zinc finger
  10. XM_024449955.1XP_024305723.1  AN1-type zinc finger protein 6 isoform X1

    Conserved Domains (2) summary
    smart00154
    Location:149186
    ZnF_AN1; AN1-like Zinc finger
    pfam01754
    Location:1235
    zf-A20; A20-like zinc finger
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