flt1 fms related receptor tyrosine kinase 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: flt1provided by ZNC
Official Full Name: fms related receptor tyrosine kinase 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-050407-1
See related: Ensembl:ENSDARG00000019371 AllianceGenome:ZFIN:ZDB-GENE-050407-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: flt1b; sFlt1; VEGFR1
Summary: Predicted to enable growth factor binding activity and vascular endothelial growth factor receptor activity. Acts upstream of or within blood vessel development; establishment of left/right asymmetry; and regulation of heart contraction. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in angioblastic mesenchymal cell; brain; cardiovascular system; endothelial cell; and somite. Human ortholog(s) of this gene implicated in Kuhnt-Junius degeneration; bronchopulmonary dysplasia; diabetic retinopathy; and pre-eclampsia. Orthologous to human FLT1 (fms related receptor tyrosine kinase 1). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 24

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	24	NC_133199.1 (25630716..25689634, complement)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	24	NC_007135.7 (21750810..21808819, complement)

Chromosome 24 - NC_133199.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A defined clathrin-mediated trafficking pathway regulates sFLT1/VEGFR1 secretion from endothelial cells.
Title: A defined clathrin-mediated trafficking pathway regulates sFLT1/VEGFR1 secretion from endothelial cells.
dnVegfaa and sFlt1 have different roles in zebrafish pancreatic vasculature and islet development
Title: Disruption of the pancreatic vasculature in zebrafish affects islet architecture and function.
sFlt1 role in the venous sprouting and spinal cord vascularization.
Title: Neuronal sFlt1 and Vegfaa determine venous sprouting and spinal cord vascularization.
we determined that radial glia control this process via the Vegf decoy receptor sFlt1: sflt1 mutants exhibit the venous over-sprouting observed in radial glia-ablated larvae, and sFlt1 overexpression rescues it. Genetic mosaic analyses show that sFlt1 function in trunk endothelial cells can limit their over-sprouting.
Title: Radial glia regulate vascular patterning around the developing spinal cord.
Flt1-tyrosine kinase (TK) activity contributed significantly in endothelial cells survival and vascular development during embryo angiogenesis in zebrafish by engaging PI3K/Akt pathway.
Title: Basal Flt1 tyrosine kinase activity is a positive regulator of endothelial survival and vascularization during zebrafish embryogenesis.
Elevated Notch signaling downstream of perturbed VEGF signaling contributes to aberrant flt-1(-/-) blood vessel formation.
Title: Flt-1 (vascular endothelial growth factor receptor-1) is essential for the vascular endothelial growth factor-Notch feedback loop during angiogenesis.
Data indicate that the increase in FLT1/sFLT1 protein levels upon miR-10 knockdown inhibited the angiogenic behavior of endothelial cells largely by antagonizing vascular endothelial growth factor receptor 2 signaling.
Title: MicroRNA-10 regulates the angiogenic behavior of zebrafish and human endothelial cells by promoting vascular endothelial growth factor signaling.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables growth factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables vascular endothelial growth factor receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables vascular endothelial growth factor receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within angiogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sprouting angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sprouting angiogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vascular endothelial growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within vascular endothelial growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vasculogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within venous blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: vascular endothelial growth factor receptor 1

Names: Flt1 (Ig-like domains 1-3); flt1a; fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor); receptor tyrosine kinase Flt1b; soluble fms-like tyrosine kinase 1

NP_001014829.3

EC 2.7.10.1

NP_001244082.1

EC 2.7.10.1

XP_073796465.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001014829.3 → NP_001014829.3 vascular endothelial growth factor receptor 1 isoform 1 precursor

See identical proteins and their annotated locations for NP_001014829.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).

Source sequence(s)

BC163921, JBMGRA010000024

UniProtKB/TrEMBL

A0A8M1N529, B3DKP1

Related

ENSDARP00000002466.8, ENSDART00000025621.10

Conserved Domains (6) summary

cd07702
Location:345 → 416

Ig_VEGFR-1; Immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 1 (VEGFR-1)

smart00409
Location:558 → 646

IG; Immunoglobulin

cd05054
Location:809 → 1138

PTKc_VEGFR; Catalytic domain of the Protein Tyrosine Kinases, Vascular Endothelial Growth Factor Receptors

pfam07679
Location:650 → 733

I-set; Immunoglobulin I-set domain

pfam13927
Location:426 → 529

Ig_3; Immunoglobulin domain

cl11960
Location:238 → 321

Ig; Immunoglobulin domain
NM_001257153.1 → NP_001244082.1 vascular endothelial growth factor receptor 1 isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks multiple 3' exons and uses an alternate 3' terminal exon compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.

Source sequence(s)

JBMGRA010000024

UniProtKB/TrEMBL

A0A8M1P2R3, F1QBD0

Related

ENSDARP00000106307.2, ENSDART00000130446.3

Conserved Domains (2) summary

smart00408
Location:344 → 396

IGc2; Immunoglobulin C-2 Type

smart00409
Location:233 → 320

IG; Immunoglobulin