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flt1 fms related receptor tyrosine kinase 1 [ Danio rerio (zebrafish) ]

Gene ID: 544667, updated on 17-Nov-2020

Summary

Official Symbol
flt1provided by ZNC
Official Full Name
fms related receptor tyrosine kinase 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-050407-1
See related
Ensembl:ENSDARG00000019371
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
flt; VEGF; flt1b; sFlt1; VEGFR1
Orthologs

Genomic context

See flt1 in Genome Data Viewer
Location:
chromosome: 24
Exon count:
31
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (21750810..21808819, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (21605636..21663645, complement)
103 previous assembly Zv9 (GCF_000002035.4) 24 NC_007135.5 (22358758..22416767, complement)

Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene fms related receptor tyrosine kinase 3 Neighboring gene poly(A) specific ribonuclease subunit PAN3 Neighboring gene suppressor of tumorigenicity 14 protein-like Neighboring gene transmembrane serine protease 7

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
vascular endothelial growth factor-activated receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
angiogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
blood vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endothelial cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hematopoietic progenitor cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of heart contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
sprouting angiogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 
vascular endothelial growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
vasculogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
venous blood vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
vascular endothelial growth factor receptor 1
Names
flt1a
fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
receptor tyrosine kinase Flt1b
soluble fms-like tyrosine kinase 1
NP_001014829.3
NP_001244082.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014829.3NP_001014829.3  vascular endothelial growth factor receptor 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001014829.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    BC163921, BX571696, CR352265
    UniProtKB/TrEMBL
    B3DKP1
    Related
    ENSDARP00000002466.8, ENSDART00000025621.10
    Conserved Domains (6) summary
    cd07702
    Location:345416
    Ig_VEGFR-1; Immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 1 (VEGFR-1)
    smart00409
    Location:558646
    IG; Immunoglobulin
    cd05054
    Location:8091138
    PTKc_VEGFR; Catalytic domain of the Protein Tyrosine Kinases, Vascular Endothelial Growth Factor Receptors
    pfam07679
    Location:650733
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:426529
    Ig_3; Immunoglobulin domain
    cl11960
    Location:238321
    Ig; Immunoglobulin domain
  2. NM_001257153.1NP_001244082.1  vascular endothelial growth factor receptor 1 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks multiple 3' exons and uses an alternate 3' terminal exon compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    BX571696, CR352265
    UniProtKB/TrEMBL
    F1QBD0
    Related
    ENSDARP00000106307.2, ENSDART00000130446.3
    Conserved Domains (3) summary
    cd07702
    Location:345416
    Ig_VEGFR-1; Immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 1 (VEGFR-1)
    pfam13927
    Location:426459
    Ig_3; Immunoglobulin domain
    cl11960
    Location:238321
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007135.7 Reference GRCz11 Primary Assembly

    Range
    21750810..21808819 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395171.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    419715..477721 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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