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MRPS21 mitochondrial ribosomal protein S21 [ Homo sapiens (human) ]

Gene ID: 54460, updated on 5-Jul-2020

Summary

Official Symbol
MRPS21provided by HGNC
Official Full Name
mitochondrial ribosomal protein S21provided by HGNC
Primary source
HGNC:HGNC:14046
See related
Ensembl:ENSG00000266472 MIM:611984
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MDS016; RPMS21; MRP-S21
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S21P family. Pseudogenes corresponding to this gene are found on chromosomes 1p, 1q, 9p, 10p, 10q, 16q, and 17q. Available sequence data analyses identified splice variants that differ in the 5' UTR; both transcripts encode the same protein. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in adrenal (RPKM 25.8), brain (RPKM 23.2) and 25 other tissues See more
Orthologs

Genomic context

See MRPS21 in Genome Data Viewer
Location:
1q21.2
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (150293842..150308979)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (150266262..150281414)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371434 Neighboring gene circadian associated repressor of transcription Neighboring gene pre-mRNA processing factor 3 Neighboring gene regulation of nuclear pre-mRNA domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
structural constituent of ribosome ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
structural constituent of ribosome NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
mitochondrial translation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
mitochondrial translational elongation TAS
Traceable Author Statement
more info
 
mitochondrial translational termination TAS
Traceable Author Statement
more info
 
translation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial small ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
28S ribosomal protein S21, mitochondrial
Names
S21mt
mitochondrial 28S ribosomal protein S21
mitochondrial small ribosomal subunit protein bS21m
NP_061870.1
NP_114107.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018997.3NP_061870.1  28S ribosomal protein S21, mitochondrial

    See identical proteins and their annotated locations for NP_061870.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC242988, U79258
    Consensus CDS
    CCDS950.1
    UniProtKB/Swiss-Prot
    P82921
    UniProtKB/TrEMBL
    Q99768
    Related
    ENSP00000461930.1, ENST00000581066.2
    Conserved Domains (1) summary
    TIGR00030
    Location:1066
    S21p; ribosomal protein S21
  2. NM_031901.6NP_114107.2  28S ribosomal protein S21, mitochondrial

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the predominant transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC242988
    Consensus CDS
    CCDS950.1
    Related
    ENSP00000480129.1, ENST00000614145.4

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    150293842..150308979
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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