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MOV10L1 Mov10 like RISC complex RNA helicase 1 [ Homo sapiens (human) ]

Gene ID: 54456, updated on 8-Jul-2021

Summary

Official Symbol
MOV10L1provided by HGNC
Official Full Name
Mov10 like RISC complex RNA helicase 1provided by HGNC
Primary source
HGNC:HGNC:7201
See related
Ensembl:ENSG00000073146 MIM:605794
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CHAMP; DJ402G11.8
Summary
This gene is similar to a mouse gene that encodes a putative RNA helicase and shows testis-specific expression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
Expression
Restricted expression toward testis (RPKM 7.8) See more
Orthologs
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Genomic context

See MOV10L1 in Genome Data Viewer
Location:
22q13.33
Exon count:
33
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (50090006..50161705)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (50528435..50600116)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene tubulin tyrosine ligase like 8 Neighboring gene modulator of VRAC current 1 Neighboring gene pannexin 2 Neighboring gene TraB domain containing

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
A genome-wide association study of behavioral disinhibition.
GeneReviews: Not available
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
GeneReviews: Not available
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ33421, DKFZp434B0717

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding TAS
Traceable Author Statement
more info
PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA binding TAS
Traceable Author Statement
more info
PubMed 
enables RNA helicase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables RNA helicase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables magnesium ion binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA methylation involved in gamete generation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in germ cell development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in male meiosis I ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in piRNA metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in post-transcriptional gene silencing by RNA IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in spermatogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in spermatogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in P granule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in P granule ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in pi-body ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
RNA helicase Mov10l1
Names
MOV10-like protein 1
Mov10 RISC complex RNA helicase like 1
Mov10-like 1
Mov10l1, Moloney leukemia virus 10-like 1, homolog
cardiac helicase activated by MEF2C protein
moloney leukemia virus 10-like protein 1
putative helicase Mov10l1
NP_001157576.1
NP_001157577.1
NP_001157578.1
NP_061868.1
XP_005261980.1
XP_011528998.1
XP_011528999.1
XP_011529000.1
XP_011529001.1
XP_011529002.1
XP_011529003.1
XP_011529004.1
XP_011529005.1
XP_011529006.1
XP_016884322.1
XP_016884323.1
XP_016884324.1
XP_016884325.1
XP_016884326.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164104.2NP_001157576.1  RNA helicase Mov10l1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AF285604, AL022328, BC150137, DB451595
    Consensus CDS
    CCDS54541.1
    UniProtKB/Swiss-Prot
    Q9BXT6
    Related
    ENSP00000379199.3, ENST00000395858.7
    Conserved Domains (3) summary
    pfam13086
    Location:745926
    AAA_11; AAA domain
    cl21455
    Location:744922
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    cl22977
    Location:9331108
    UvrD_C_2; UvrD-like helicase C-terminal domain
  2. NM_001164105.2NP_001157577.1  RNA helicase Mov10l1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (3) has shorter and distinct N- and C-termini compared to isoform 1.
    Source sequence(s)
    AF285604, AK302401, AL022328, AL034546
    Consensus CDS
    CCDS54542.1
    UniProtKB/Swiss-Prot
    Q9BXT6
    Related
    ENSP00000438542.1, ENST00000540615.5
    Conserved Domains (3) summary
    COG1112
    Location:4061143
    DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
    pfam13087
    Location:9131129
    AAA_12; AAA domain
    cl21455
    Location:724902
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. NM_001164106.1NP_001157578.1  RNA helicase Mov10l1 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (4) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AF285604, AK000033, BP382225
    Consensus CDS
    CCDS54543.1
    UniProtKB/Swiss-Prot
    Q9BXT6
    Related
    ENSP00000379193.1, ENST00000395852.5
    Conserved Domains (3) summary
    COG1112
    Location:2299
    DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
    pfam13087
    Location:60276
    AAA_12; AAA domain
    cl21455
    Location:1049
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  4. NM_018995.3NP_061868.1  RNA helicase Mov10l1 isoform 1

    See identical proteins and their annotated locations for NP_061868.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AF285604, AL022328, DB451595
    Consensus CDS
    CCDS14084.1
    UniProtKB/Swiss-Prot
    Q9BXT6
    Related
    ENSP00000262794.5, ENST00000262794.10
    Conserved Domains (3) summary
    COG1112
    Location:4261172
    DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
    pfam13087
    Location:9331149
    AAA_12; AAA domain
    cl21455
    Location:744922
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    50090006..50161705
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530696.1XP_011528998.1  RNA helicase Mov10l1 isoform X1

    Conserved Domains (3) summary
    COG1112
    Location:4261217
    DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
    pfam13087
    Location:9331194
    AAA_12; AAA domain
    cl21455
    Location:744922
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. XM_017028833.1XP_016884322.1  RNA helicase Mov10l1 isoform X3

  3. XM_011530698.1XP_011529000.1  RNA helicase Mov10l1 isoform X4

    Conserved Domains (3) summary
    COG1112
    Location:3791170
    DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
    pfam13087
    Location:8861147
    AAA_12; AAA domain
    cl21455
    Location:697875
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  4. XM_011530701.1XP_011529003.1  RNA helicase Mov10l1 isoform X7

    Conserved Domains (3) summary
    pfam13086
    Location:745926
    AAA_11; AAA domain
    cl21455
    Location:744922
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    cl22977
    Location:9331072
    UvrD_C_2; UvrD-like helicase C-terminal domain
  5. XM_011530704.1XP_011529006.1  RNA helicase Mov10l1 isoform X11

    Conserved Domains (1) summary
    pfam14444
    Location:196240
    S1-like; S1-like
  6. XM_017028834.1XP_016884323.1  RNA helicase Mov10l1 isoform X9

    Conserved Domains (1) summary
    pfam14444
    Location:196240
    S1-like; S1-like
  7. XM_017028837.1XP_016884326.1  RNA helicase Mov10l1 isoform X12

    Conserved Domains (1) summary
    pfam14444
    Location:196240
    S1-like; S1-like
  8. XM_011530697.1XP_011528999.1  RNA helicase Mov10l1 isoform X2

    Conserved Domains (3) summary
    COG1112
    Location:4061197
    DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
    pfam13087
    Location:9131174
    AAA_12; AAA domain
    cl21455
    Location:724902
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  9. XM_011530702.1XP_011529004.1  RNA helicase Mov10l1 isoform X8

    Conserved Domains (3) summary
    COG1112
    Location:185976
    DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
    pfam13087
    Location:692953
    AAA_12; AAA domain
    cl21455
    Location:503681
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  10. XM_011530699.1XP_011529001.1  RNA helicase Mov10l1 isoform X5

    See identical proteins and their annotated locations for XP_011529001.1

    Conserved Domains (3) summary
    COG1112
    Location:3741165
    DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
    pfam13087
    Location:8811142
    AAA_12; AAA domain
    cl21455
    Location:692870
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  11. XM_005261923.4XP_005261980.1  RNA helicase Mov10l1 isoform X6

    Conserved Domains (3) summary
    COG1112
    Location:4061152
    DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
    pfam13087
    Location:9131129
    AAA_12; AAA domain
    cl21455
    Location:724902
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  12. XM_011530700.2XP_011529002.1  RNA helicase Mov10l1 isoform X5

    See identical proteins and their annotated locations for XP_011529002.1

    Conserved Domains (3) summary
    COG1112
    Location:3741165
    DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
    pfam13087
    Location:8811142
    AAA_12; AAA domain
    cl21455
    Location:692870
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  13. XM_011530703.1XP_011529005.1  RNA helicase Mov10l1 isoform X10

    Conserved Domains (3) summary
    pfam13086
    Location:219400
    AAA_11; AAA domain
    pfam13087
    Location:407668
    AAA_12; AAA domain
    cl21455
    Location:218396
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  14. XM_017028835.1XP_016884324.1  RNA helicase Mov10l1 isoform X10

    Conserved Domains (3) summary
    pfam13086
    Location:219400
    AAA_11; AAA domain
    pfam13087
    Location:407668
    AAA_12; AAA domain
    cl21455
    Location:218396
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  15. XM_017028836.1XP_016884325.1  RNA helicase Mov10l1 isoform X10

    Conserved Domains (3) summary
    pfam13086
    Location:219400
    AAA_11; AAA domain
    pfam13087
    Location:407668
    AAA_12; AAA domain
    cl21455
    Location:218396
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RNA

  1. XR_002958704.1 RNA Sequence

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