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FBXO42 F-box protein 42 [ Homo sapiens (human) ]

Gene ID: 54455, updated on 1-Jun-2020

Summary

Official Symbol
FBXO42provided by HGNC
Official Full Name
F-box protein 42provided by HGNC
Primary source
HGNC:HGNC:29249
See related
Ensembl:ENSG00000037637 MIM:609109
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
JFK; Fbx42
Summary
Members of the F-box protein family, such as FBXO42, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (SKP1A; MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Dec 2010]
Expression
Ubiquitous expression in skin (RPKM 6.4), fat (RPKM 5.1) and 25 other tissues See more
Orthologs

Genomic context

See FBXO42 in Genome Data Viewer
Location:
1p36.13
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (16246840..16352480, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (16573339..16678965, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ciliogenesis and planar polarity effector 2 Neighboring gene metallothionein 1X pseudogene 1 Neighboring gene ribosomal protein L22 pseudogene 3 Neighboring gene SUZ RNA binding domain containing 1 Neighboring gene spermatogenesis associated 21

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1332

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
F-box only protein 42
Names
just one F-box and Kelch domain-containing protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018994.3NP_061867.1  F-box only protein 42

    See identical proteins and their annotated locations for NP_061867.1

    Status: VALIDATED

    Source sequence(s)
    AB037753, AW449773, BC063864, DA488838, HY007337
    Consensus CDS
    CCDS30613.1
    UniProtKB/Swiss-Prot
    Q6P3S6
    UniProtKB/TrEMBL
    A0A024QZB0
    Related
    ENSP00000364742.3, ENST00000375592.8
    Conserved Domains (5) summary
    sd00038
    Location:119168
    Kelch; KELCH repeat [structural motif]
    pfam12937
    Location:4782
    F-box-like; F-box-like
    pfam13415
    Location:130182
    Kelch_3; Galactose oxidase, central domain
    pfam13854
    Location:229268
    Kelch_5; Kelch motif
    cl27059
    Location:228360
    Guanylate_kin; Guanylate kinase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    16246840..16352480 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017001502.1XP_016856991.1  F-box only protein 42 isoform X2

  2. XM_017001503.1XP_016856992.1  F-box only protein 42 isoform X2

  3. XM_006710698.3XP_006710761.1  F-box only protein 42 isoform X1

    See identical proteins and their annotated locations for XP_006710761.1

    UniProtKB/Swiss-Prot
    Q6P3S6
    UniProtKB/TrEMBL
    A0A024QZB0
    Conserved Domains (5) summary
    sd00038
    Location:119168
    Kelch; KELCH repeat [structural motif]
    pfam12937
    Location:4782
    F-box-like; F-box-like
    pfam13415
    Location:130182
    Kelch_3; Galactose oxidase, central domain
    pfam13854
    Location:229268
    Kelch_5; Kelch motif
    cl27059
    Location:228360
    Guanylate_kin; Guanylate kinase

RNA

  1. XR_001737235.1 RNA Sequence

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