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ATAD2B ATPase family AAA domain containing 2B [ Homo sapiens (human) ]

Gene ID: 54454, updated on 24-Nov-2020

Summary

Official Symbol
ATAD2Bprovided by HGNC
Official Full Name
ATPase family AAA domain containing 2Bprovided by HGNC
Primary source
HGNC:HGNC:29230
See related
Ensembl:ENSG00000119778 MIM:615347
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene belongs to the AAA ATPase family. This family member includes an N-terminal bromodomain. It has been found to be localized to the nucleus, partly to replication sites, consistent with a chromatin-related function. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Expression
Ubiquitous expression in lymph node (RPKM 1.9), testis (RPKM 1.9) and 25 other tissues See more
Orthologs

Genomic context

See ATAD2B in Genome Data Viewer
Location:
2p24.1-p23.3
Exon count:
40
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (23687624..23927123, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (23971534..24149978, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene kelch like family member 29 Neighboring gene uncharacterized LOC105374325 Neighboring gene uncharacterized LOC102723401 Neighboring gene phosphoglycerate mutase 1 pseudogene 6 Neighboring gene ribosomal protein S13 pseudogene 4 Neighboring gene UBX domain protein 2A Neighboring gene succinate dehydrogenase complex subunit C pseudogene 3 Neighboring gene RNA, 7SL, cytoplasmic 610, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1240, MGC88424

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lysine-acetylated histone binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
negative regulation of chromatin silencing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ATPase family AAA domain-containing protein 2B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029017.2 RefSeqGene

    Range
    4944..183403
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001242338.3NP_001229267.2  ATPase family AAA domain-containing protein 2B isoform 2

    Status: REVIEWED

    Source sequence(s)
    AB033066, AC066692, AK094821, BC171846, BM974506
    UniProtKB/Swiss-Prot
    Q9ULI0
    Conserved Domains (4) summary
    cd05528
    Location:9601066
    Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
    smart00382
    Location:433574
    AAA; ATPases associated with a variety of cellular activities
    COG5076
    Location:8521081
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    pfam00004
    Location:438572
    AAA; ATPase family associated with various cellular activities (AAA)
  2. NM_001354107.2NP_001341036.1  ATPase family AAA domain-containing protein 2B isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC009242, AC066692, AC079924, BM974506, KF456640
    Conserved Domains (2) summary
    cd05528
    Location:9741080
    Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
    cl27568
    Location:411683
    TIP49; TIP49 C-terminus
  3. NM_017552.4NP_060022.2  ATPase family AAA domain-containing protein 2B isoform 1

    Status: REVIEWED

    Source sequence(s)
    AB033066, AC066692, AK094821, AK125718, BC171846, BM974506
    Consensus CDS
    CCDS46227.1
    UniProtKB/Swiss-Prot
    Q9ULI0
    UniProtKB/TrEMBL
    B3KWS5
    Related
    ENSP00000238789.5, ENST00000238789.10
    Conserved Domains (4) summary
    cd05528
    Location:9601071
    Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
    smart00382
    Location:433574
    AAA; ATPases associated with a variety of cellular activities
    COG5076
    Location:8521086
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    pfam00004
    Location:438572
    AAA; ATPase family associated with various cellular activities (AAA)

RNA

  1. NR_125717.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AB033066, AC066692, AK094821, BC171846, BM974506

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    23687624..23927123 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006712030.4XP_006712093.1  ATPase family AAA domain-containing protein 2B isoform X6

    Conserved Domains (4) summary
    cd05528
    Location:9741085
    Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
    smart00382
    Location:447588
    AAA; ATPases associated with a variety of cellular activities
    COG5076
    Location:8661100
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    pfam00004
    Location:452586
    AAA; ATPase family associated with various cellular activities (AAA)
  2. XM_017004375.2XP_016859864.1  ATPase family AAA domain-containing protein 2B isoform X4

  3. XM_011532920.3XP_011531222.1  ATPase family AAA domain-containing protein 2B isoform X3

    Conserved Domains (4) summary
    cd05528
    Location:9601071
    Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
    smart00382
    Location:433574
    AAA; ATPases associated with a variety of cellular activities
    COG5076
    Location:8521086
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    pfam00004
    Location:438572
    AAA; ATPase family associated with various cellular activities (AAA)
  4. XM_011532919.3XP_011531221.1  ATPase family AAA domain-containing protein 2B isoform X2

    Conserved Domains (4) summary
    cd05528
    Location:9741080
    Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
    smart00382
    Location:447588
    AAA; ATPases associated with a variety of cellular activities
    COG5076
    Location:8661095
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    pfam00004
    Location:452586
    AAA; ATPase family associated with various cellular activities (AAA)
  5. XM_011532918.3XP_011531220.1  ATPase family AAA domain-containing protein 2B isoform X1

    Conserved Domains (4) summary
    cd05528
    Location:9741085
    Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
    smart00382
    Location:447588
    AAA; ATPases associated with a variety of cellular activities
    COG5076
    Location:8661100
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    pfam00004
    Location:452586
    AAA; ATPase family associated with various cellular activities (AAA)
  6. XM_005264372.4XP_005264429.2  ATPase family AAA domain-containing protein 2B isoform X5

    Conserved Domains (4) summary
    cd05528
    Location:9741085
    Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
    smart00382
    Location:447588
    AAA; ATPases associated with a variety of cellular activities
    COG5076
    Location:8661100
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    pfam00004
    Location:452586
    AAA; ATPase family associated with various cellular activities (AAA)
  7. XM_011532925.3XP_011531227.1  ATPase family AAA domain-containing protein 2B isoform X8

    Conserved Domains (3) summary
    cd05528
    Location:9741059
    Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
    smart00382
    Location:447588
    AAA; ATPases associated with a variety of cellular activities
    pfam00004
    Location:452586
    AAA; ATPase family associated with various cellular activities (AAA)
  8. XM_011532924.3XP_011531226.1  ATPase family AAA domain-containing protein 2B isoform X7

    Conserved Domains (3) summary
    cd05528
    Location:9741059
    Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
    smart00382
    Location:447588
    AAA; ATPases associated with a variety of cellular activities
    pfam00004
    Location:452586
    AAA; ATPase family associated with various cellular activities (AAA)
  9. XM_006712031.4XP_006712094.1  ATPase family AAA domain-containing protein 2B isoform X9

    Conserved Domains (3) summary
    cd05528
    Location:9741058
    Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
    smart00382
    Location:447588
    AAA; ATPases associated with a variety of cellular activities
    pfam00004
    Location:452586
    AAA; ATPase family associated with various cellular activities (AAA)
  10. XM_011532928.2XP_011531230.1  ATPase family AAA domain-containing protein 2B isoform X10

    See identical proteins and their annotated locations for XP_011531230.1

    Conserved Domains (2) summary
    smart00382
    Location:447588
    AAA; ATPases associated with a variety of cellular activities
    pfam00004
    Location:452586
    AAA; ATPase family associated with various cellular activities (AAA)
  11. XM_011532929.3XP_011531231.1  ATPase family AAA domain-containing protein 2B isoform X11

    Conserved Domains (2) summary
    smart00382
    Location:447588
    AAA; ATPases associated with a variety of cellular activities
    pfam00004
    Location:452586
    AAA; ATPase family associated with various cellular activities (AAA)
  12. XM_011532931.3XP_011531233.1  ATPase family AAA domain-containing protein 2B isoform X13

    Conserved Domains (2) summary
    smart00382
    Location:447588
    AAA; ATPases associated with a variety of cellular activities
    pfam00004
    Location:452586
    AAA; ATPase family associated with various cellular activities (AAA)
  13. XM_011532930.3XP_011531232.1  ATPase family AAA domain-containing protein 2B isoform X12

    Conserved Domains (2) summary
    smart00382
    Location:447588
    AAA; ATPases associated with a variety of cellular activities
    pfam00004
    Location:452586
    AAA; ATPase family associated with various cellular activities (AAA)
  14. XM_011532932.2XP_011531234.1  ATPase family AAA domain-containing protein 2B isoform X14

    See identical proteins and their annotated locations for XP_011531234.1

    Conserved Domains (2) summary
    smart00382
    Location:447588
    AAA; ATPases associated with a variety of cellular activities
    pfam00004
    Location:452586
    AAA; ATPase family associated with various cellular activities (AAA)

RNA

  1. XR_001738780.2 RNA Sequence

  2. XR_001738781.2 RNA Sequence

  3. XR_001738783.2 RNA Sequence

  4. XR_001738784.2 RNA Sequence

  5. XR_001738782.2 RNA Sequence

  6. XR_001738785.2 RNA Sequence

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