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PON2 paraoxonase 2 [ Homo sapiens (human) ]

Gene ID: 5445, updated on 1-Jun-2020

Summary

Official Symbol
PON2provided by HGNC
Official Full Name
paraoxonase 2provided by HGNC
Primary source
HGNC:HGNC:9205
See related
Ensembl:ENSG00000105854 MIM:602447
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 81.0), adrenal (RPKM 61.6) and 23 other tissues See more
Orthologs

Genomic context

See PON2 in Genome Data Viewer
Location:
7q21.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (95404862..95435072, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (95034174..95064636, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene paraoxonase 3 Neighboring gene uncharacterized LOC107986822 Neighboring gene Sharpr-MPRA regulatory region 10642 Neighboring gene uncharacterized LOC107986823

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 is identified to have a physical interaction with paraoxonase 2 (PON2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 is identified to have a physical interaction with paraoxonase 2 (PON2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Rev rev HIV-1 Rev interacting protein, paraoxonase 2 (PON2), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with PON2 is increased by RRE PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
acyl-L-homoserine-lactone lactonohydrolase activity IEA
Inferred from Electronic Annotation
more info
 
arylesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
aromatic compound catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
lipoxygenase pathway TAS
Traceable Author Statement
more info
 
response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
response to toxic substance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
 
lysosome IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serum paraoxonase/arylesterase 2
Names
A-esterase 2
PON 2
aromatic esterase 2
arylesterase 2
paraoxonase nirs
serum aryldialkylphosphatase 2
NP_000296.2
NP_001018171.1
XP_005250510.1
XP_016867846.1
XP_016867847.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008725.1 RefSeqGene

    Range
    5045..35211
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000305.3NP_000296.2  serum paraoxonase/arylesterase 2 isoform 1

    See identical proteins and their annotated locations for NP_000296.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF001601, BC040010, CB961097
    Consensus CDS
    CCDS5640.1
    UniProtKB/Swiss-Prot
    Q15165
    UniProtKB/TrEMBL
    A0A0J9YYG4
    Related
    ENSP00000222572.3, ENST00000222572.8
    Conserved Domains (1) summary
    pfam01731
    Location:167252
    Arylesterase; Arylesterase
  2. NM_001018161.1NP_001018171.1  serum paraoxonase/arylesterase 2 isoform 2

    See identical proteins and their annotated locations for NP_001018171.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate, in-frame splice site in the coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AC005021, BC093006, CB961097
    Consensus CDS
    CCDS47644.1
    UniProtKB/TrEMBL
    J3QT77
    Related
    ENSP00000404622.2, ENST00000433091.6
    Conserved Domains (1) summary
    pfam01731
    Location:155240
    Arylesterase; Arylesterase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    95404862..95435072 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005250453.1XP_005250510.1  serum paraoxonase/arylesterase 2 isoform X1

    See identical proteins and their annotated locations for XP_005250510.1

    Conserved Domains (1) summary
    pfam01731
    Location:99184
    Arylesterase; Arylesterase
  2. XM_017012357.2XP_016867846.1  serum paraoxonase/arylesterase 2 isoform X2

    Conserved Domains (1) summary
    pfam01731
    Location:97182
    Arylesterase; Arylesterase
  3. XM_017012358.2XP_016867847.1  serum paraoxonase/arylesterase 2 isoform X3

    Conserved Domains (1) summary
    pfam01731
    Location:81166
    Arylesterase; Arylesterase
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