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GFOD1 glucose-fructose oxidoreductase domain containing 1 [ Homo sapiens (human) ]

Gene ID: 54438, updated on 24-Nov-2021

Summary

Official Symbol
GFOD1provided by HGNC
Official Full Name
glucose-fructose oxidoreductase domain containing 1provided by HGNC
Primary source
HGNC:HGNC:21096
See related
Ensembl:ENSG00000145990
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ADG-90; C6orf114
Expression
Broad expression in brain (RPKM 7.3), fat (RPKM 5.7) and 21 other tissues See more
Orthologs
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Genomic context

See GFOD1 in Genome Data Viewer
Location:
6p24.1-p23
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (13357830..13487600, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (13358062..13487832, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene TBC1D7-LOC100130357 readthrough Neighboring gene TBC1 domain family member 7 Neighboring gene uncharacterized LOC105374936 Neighboring gene GFOD1 antisense RNA 1 Neighboring gene ribosomal protein S4X pseudogene 7 Neighboring gene RN7SK pseudogene 204

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20330, FLJ30569, FLJ45648, MGC70653, DKFZp547P158

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
glucose-fructose oxidoreductase domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242628.2NP_001229557.1  glucose-fructose oxidoreductase domain-containing protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001229557.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' exon, resulting in a downstream AUG start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AF264036, AL589984, AW137218, BC124557
    Consensus CDS
    CCDS56397.1
    UniProtKB/Swiss-Prot
    Q9NXC2
    Related
    ENSP00000479493.1, ENST00000612338.4
    Conserved Domains (1) summary
    cl40708
    Location:19260
    MviM; Predicted dehydrogenase [General function prediction only]
  2. NM_001242629.2NP_001229558.1  glucose-fructose oxidoreductase domain-containing protein 1 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001229558.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has an alternate 3' exon, compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL583828
    Consensus CDS
    CCDS64351.1
    UniProtKB/Swiss-Prot
    Q9NXC2
    UniProtKB/TrEMBL
    S4R302
    Related
    ENSP00000473812.1, ENST00000603223.1
    Conserved Domains (1) summary
    cl21454
    Location:587
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  3. NM_001242630.2NP_001229559.1  glucose-fructose oxidoreductase domain-containing protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001229559.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate 5' exon, resulting in a downstream AUG start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK027010, AL589984, AW137218
    Consensus CDS
    CCDS56397.1
    UniProtKB/Swiss-Prot
    Q9NXC2
    Related
    ENSP00000368586.1, ENST00000379284.1
    Conserved Domains (1) summary
    cl40708
    Location:19260
    MviM; Predicted dehydrogenase [General function prediction only]
  4. NM_018988.4NP_061861.1  glucose-fructose oxidoreductase domain-containing protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_061861.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL583828, AL589984
    Consensus CDS
    CCDS4524.1
    UniProtKB/Swiss-Prot
    Q9NXC2
    Related
    ENSP00000368589.3, ENST00000379287.4
    Conserved Domains (1) summary
    COG0673
    Location:5363
    MviM; Predicted dehydrogenase [General function prediction only]

RNA

  1. NR_038459.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) is supported by mRNAs and ESTs, but none of the open reading frame is supported, so this variant is thought to be a non-coding transcript. The transcript shares the 3' exon with variant 4 and does not share any exon with variant 1.
    Source sequence(s)
    AL583828, BC066553, BP283322
    Related
    ENST00000605067.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    13357830..13487600 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_033069.2: Suppressed sequence

    Description
    NM_033069.2: This RefSeq was permanently suppressed because it is now thought that this gene does not encode a protein.
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