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SSH1 slingshot protein phosphatase 1 [ Homo sapiens (human) ]

Gene ID: 54434, updated on 11-Sep-2019

Summary

Official Symbol
SSH1provided by HGNC
Official Full Name
slingshot protein phosphatase 1provided by HGNC
Primary source
HGNC:HGNC:30579
See related
Ensembl:ENSG00000084112 MIM:606778
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SSH1L
Summary
The protein encoded by this gene belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by kinases such as LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins. The SSH family thus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Expression
Ubiquitous expression in gall bladder (RPKM 6.2), endometrium (RPKM 5.8) and 25 other tissues See more
Orthologs

Genomic context

See SSH1 in Genome Data Viewer
Location:
12q24.11
Exon count:
20
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (108778191..108857606, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (109176466..109251359, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene coronin 1C Neighboring gene Sharpr-MPRA regulatory region 839 Neighboring gene uncharacterized LOC105369969 Neighboring gene uncharacterized LOC101929204 Neighboring gene microRNA 619 Neighboring gene D-amino acid oxidase Neighboring gene RNA, U6 small nuclear 361, pseudogene Neighboring gene SV2 related protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21928, FLJ38102, KIAA1298

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin binding IDA
Inferred from Direct Assay
more info
PubMed 
phosphoprotein phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphoprotein phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
phosphoprotein phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine/serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to ATP IDA
Inferred from Direct Assay
more info
PubMed 
excitatory chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of AMPA glutamate receptor clustering IEA
Inferred from Electronic Annotation
more info
 
positive regulation of excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neuron death IEA
Inferred from Electronic Annotation
more info
 
positive regulation of synaptic plasticity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of vascular associated smooth muscle cell migration IEA
Inferred from Electronic Annotation
more info
 
protein dephosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cellular protein metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cleavage furrow IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
growth cone IEA
Inferred from Electronic Annotation
more info
 
lamellipodium IEA
Inferred from Electronic Annotation
more info
 
midbody IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein phosphatase Slingshot homolog 1
Names
SSH-like protein 1
hSSH-1L
slingshot homolog 1
NP_001154802.1
NP_001154803.1
NP_061857.3
XP_005269041.1
XP_005269042.1
XP_011536799.1
XP_011536801.1
XP_011536802.1
XP_011536803.1
XP_016874980.1
XP_016874981.1
XP_016874982.1
XP_016874983.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029846.1 RefSeqGene

    Range
    5001..79894
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001161330.2NP_001154802.1  protein phosphatase Slingshot homolog 1 isoform 2

    See identical proteins and their annotated locations for NP_001154802.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs at the 3' end compared to variant 1. This results in a shorter isoform (2, also known as SSH-1S) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AB072356, BP363810
    Consensus CDS
    CCDS55882.1
    UniProtKB/Swiss-Prot
    Q8WYL5
    Related
    ENSP00000448824.1, ENST00000551165.5
    Conserved Domains (3) summary
    cd11652
    Location:3237
    SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
    cd00127
    Location:308444
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    pfam08766
    Location:252303
    DEK_C; DEK C terminal domain
  2. NM_001161331.1NP_001154803.1  protein phosphatase Slingshot homolog 1 isoform 3

    See identical proteins and their annotated locations for NP_001154803.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternative 5' terminal exon, and differs at the 3' end compared to variant 1. This results in a shorter isoform (3) with distinct N- and C-termini compared to isoform 1.
    Source sequence(s)
    AB072356, AK095421
    Consensus CDS
    CCDS53825.1
    UniProtKB/Swiss-Prot
    Q8WYL5
    Related
    ENSP00000326107.5, ENST00000326470.9
    Conserved Domains (3) summary
    cd11652
    Location:41248
    SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
    cd00127
    Location:319455
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    pfam08766
    Location:263314
    DEK_C; DEK C terminal domain
  3. NM_018984.4NP_061857.3  protein phosphatase Slingshot homolog 1 isoform 1

    See identical proteins and their annotated locations for NP_061857.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1, also known as SSH-1L). This isoform has been shown to be enzymatically active (PMID:11832213).
    Source sequence(s)
    AB072355, AC087893, AI621348, BC020243, BP363810
    Consensus CDS
    CCDS9121.1
    UniProtKB/Swiss-Prot
    Q8WYL5
    Related
    ENSP00000315713.5, ENST00000326495.10
    Conserved Domains (3) summary
    cd11652
    Location:3237
    SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
    cd00127
    Location:308444
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    pfam08766
    Location:252303
    DEK_C; DEK C terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    108778191..108857606 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017019492.1XP_016874981.1  protein phosphatase Slingshot homolog 1 isoform X6

    Conserved Domains (3) summary
    cd11652
    Location:10111
    SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
    cd00127
    Location:182318
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    pfam08766
    Location:126177
    DEK_C; DEK C terminal domain
  2. XM_005268985.2XP_005269042.1  protein phosphatase Slingshot homolog 1 isoform X5

    See identical proteins and their annotated locations for XP_005269042.1

    Conserved Domains (3) summary
    cd11652
    Location:1157
    SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
    cd00127
    Location:228364
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    pfam08766
    Location:172223
    DEK_C; DEK C terminal domain
  3. XM_005268984.4XP_005269041.1  protein phosphatase Slingshot homolog 1 isoform X2

    Conserved Domains (3) summary
    cd11652
    Location:11237
    SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
    cd00127
    Location:308444
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    pfam08766
    Location:252303
    DEK_C; DEK C terminal domain
  4. XM_017019493.1XP_016874982.1  protein phosphatase Slingshot homolog 1 isoform X7

    UniProtKB/Swiss-Prot
    Q8WYL5
    Conserved Domains (1) summary
    cd00127
    Location:23132
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
  5. XM_011538499.1XP_011536801.1  protein phosphatase Slingshot homolog 1 isoform X4

    Conserved Domains (3) summary
    cd11652
    Location:41248
    SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
    pfam08766
    Location:263314
    DEK_C; DEK C terminal domain
    cl21483
    Location:320401
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  6. XM_011538497.1XP_011536799.1  protein phosphatase Slingshot homolog 1 isoform X1

    Conserved Domains (3) summary
    cd11652
    Location:41248
    SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
    cd00127
    Location:319455
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    pfam08766
    Location:263314
    DEK_C; DEK C terminal domain
  7. XM_017019494.1XP_016874983.1  protein phosphatase Slingshot homolog 1 isoform X7

    UniProtKB/Swiss-Prot
    Q8WYL5
    Conserved Domains (1) summary
    cd00127
    Location:23132
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
  8. XM_017019491.2XP_016874980.1  protein phosphatase Slingshot homolog 1 isoform X3

  9. XM_011538501.3XP_011536803.1  protein phosphatase Slingshot homolog 1 isoform X5

    See identical proteins and their annotated locations for XP_011536803.1

    Conserved Domains (3) summary
    cd11652
    Location:1157
    SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
    cd00127
    Location:228364
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    pfam08766
    Location:172223
    DEK_C; DEK C terminal domain
  10. XM_011538500.3XP_011536802.1  protein phosphatase Slingshot homolog 1 isoform X5

    See identical proteins and their annotated locations for XP_011536802.1

    Conserved Domains (3) summary
    cd11652
    Location:1157
    SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
    cd00127
    Location:228364
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    pfam08766
    Location:172223
    DEK_C; DEK C terminal domain
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