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DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 [ Homo sapiens (human) ]

Gene ID: 54431, updated on 15-Apr-2019

Summary

Official Symbol
DNAJC10provided by HGNC
Official Full Name
DnaJ heat shock protein family (Hsp40) member C10provided by HGNC
Primary source
HGNC:HGNC:24637
See related
Ensembl:ENSG00000077232 MIM:607987
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
JPDI; MTHr; ERdj5; PDIA19
Summary
This gene encodes an endoplasmic reticulum co-chaperone which is part of the endoplasmic reticulum-associated degradation complex involved in recognizing and degrading misfolded proteins. The encoded protein reduces incorrect disulfide bonds in misfolded glycoproteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012]
Expression
Ubiquitous expression in endometrium (RPKM 35.6), thyroid (RPKM 29.7) and 25 other tissues See more
Orthologs

Genomic context

See DNAJC10 in Genome Data Viewer
Location:
2q32.1
Exon count:
26
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (182715979..182780025)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (183580768..183644752)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 1A Neighboring gene RNA, 7SL, cytoplasmic 267, pseudogene Neighboring gene uncharacterized LOC101929976 Neighboring gene ribosomal protein L31 pseudogene 15 Neighboring gene frizzled related protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with DNAJC10; predicted interaction to be within the endoplasmic reticulum and function as chaperone for endoplasmic reticulum-associated degradation PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
    Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
  • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
    Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC104194, DKFZp434J1813

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATPase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
ATPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Hsp70 protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
chaperone binding IDA
Inferred from Direct Assay
more info
PubMed 
disulfide oxidoreductase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
misfolded protein binding IDA
Inferred from Direct Assay
more info
PubMed 
oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein disulfide oxidoreductase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein disulfide oxidoreductase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
cell redox homeostasis IEA
Inferred from Electronic Annotation
more info
 
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ATPase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein folding in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
response to endoplasmic reticulum stress IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-dependent ERAD pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum chaperone complex IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum lumen IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 

General protein information

Preferred Names
dnaJ homolog subfamily C member 10
Names
DnaJ (Hsp40) homolog, subfamily C, member 10
ER-resident protein ERdj5
J-domain-containing protein disulfide isomerase-like protein
endoplasmic reticulum DNA J domain-containing protein 5
macrothioredoxin
protein disulfide isomerase family A, member 19

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271581.1NP_001258510.1  dnaJ homolog subfamily C member 10 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001258510.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform (1).
    Source sequence(s)
    AA651917, AC105396, AK027647, AY358577, DA106532
    Consensus CDS
    CCDS74613.1
    UniProtKB/Swiss-Prot
    Q8IXB1
    Related
    ENSP00000479930.1, ENST00000616986.4
    Conserved Domains (6) summary
    COG0484
    Location:34132
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    cd03003
    Location:129229
    PDI_a_ERdj5_N; PDIa family, N-terminal ERdj5 subfamily; ERdj5, also known as JPDI and macrothioredoxin, is a protein containing an N-terminal DnaJ domain and four redox active TRX domains. This subfamily is comprised of the first TRX domain of ERdj5 located after the ...
    cd03004
    Location:510617
    PDI_a_ERdj5_C; PDIa family, C-terminal ERdj5 subfamily; ERdj5, also known as JPDI and macrothioredoxin, is a protein containing an N-terminal DnaJ domain and four redox active TRX domains. This subfamily is composed of the three TRX domains located at the C-terminal ...
    TIGR01130
    Location:130614
    ER_PDI_fam; protein disulfide isomerase, eukaryotic
    pfam00226
    Location:3597
    DnaJ; DnaJ domain
    cl00388
    Location:347401
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
  2. NM_018981.3NP_061854.1  dnaJ homolog subfamily C member 10 isoform 1 precursor

    See identical proteins and their annotated locations for NP_061854.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC073951, AC105396, KF456753
    Consensus CDS
    CCDS33345.1
    UniProtKB/Swiss-Prot
    Q8IXB1
    Related
    ENSP00000264065.6, ENST00000264065.12
    Conserved Domains (3) summary
    COG0484
    Location:34132
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    cd03003
    Location:129229
    PDI_a_ERdj5_N; PDIa family, N-terminal ERdj5 subfamily; ERdj5, also known as JPDI and macrothioredoxin, is a protein containing an N-terminal DnaJ domain and four redox active TRX domains. This subfamily is comprised of the first TRX domain of ERdj5 located after the ...
    cd03004
    Location:556663
    PDI_a_ERdj5_C; PDIa family, C-terminal ERdj5 subfamily; ERdj5, also known as JPDI and macrothioredoxin, is a protein containing an N-terminal DnaJ domain and four redox active TRX domains. This subfamily is composed of the three TRX domains located at the C-terminal ...

RNA

  1. NR_073365.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA651917, AC105396, AK027647, AL137648, AL832632, BC107425, BC126168, DA106532
    Related
    ENST00000650903.1
  2. NR_073366.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in an internal exon and contains an alternate exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA651917, AC105396, AK027647, AL137648, AL832632, BC070034, BC107425, BC126168, DA106532
  3. NR_073367.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks two alternate internal exons and contains one alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA651917, AC105396, AK027647, AY089971, DA106532

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    182715979..182780025
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024452971.1XP_024308739.1  dnaJ homolog subfamily C member 10 isoform X1

    Conserved Domains (3) summary
    COG0484
    Location:34132
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    cd03003
    Location:129229
    PDI_a_ERdj5_N; PDIa family, N-terminal ERdj5 subfamily; ERdj5, also known as JPDI and macrothioredoxin, is a protein containing an N-terminal DnaJ domain and four redox active TRX domains. This subfamily is comprised of the first TRX domain of ERdj5 located after the ...
    cd03004
    Location:556663
    PDI_a_ERdj5_C; PDIa family, C-terminal ERdj5 subfamily; ERdj5, also known as JPDI and macrothioredoxin, is a protein containing an N-terminal DnaJ domain and four redox active TRX domains. This subfamily is composed of the three TRX domains located at the C-terminal ...
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