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TAS2R5 taste 2 receptor member 5 [ Homo sapiens (human) ]

Gene ID: 54429, updated on 10-Dec-2019

Summary

Official Symbol
TAS2R5provided by HGNC
Official Full Name
taste 2 receptor member 5provided by HGNC
Primary source
HGNC:HGNC:14912
See related
Ensembl:ENSG00000127366 MIM:605062
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
T2R5
Summary
This gene encodes a bitter taste receptor; bitter taste receptors are members of the G protein-coupled receptor superfamily and are specifically expressed by taste receptor cells of the tongue and palate epithelia. Each of these apparently intronless taste receptor genes encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes on chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008]
Orthologs

Genomic context

See TAS2R5 in Genome Data Viewer
Location:
7q34
Exon count:
1
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (141790217..141791367)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (141487129..141491338)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene taste 2 receptor member 4 Neighboring gene taste 2 receptor member 6 pseudogene Neighboring gene MT-CO1 pseudogene 55 Neighboring gene MT-ND2 pseudogene 5

Genomic regions, transcripts, and products

Pathways from BioSystems

  • Class C/3 (Metabotropic glutamate/pheromone receptors), organism-specific biosystem (from REACTOME)
    Class C/3 (Metabotropic glutamate/pheromone receptors), organism-specific biosystemThe class C G-protein-coupled receptors are a class of G-protein coupled receptors that include the metabotropic glutamate receptors and several additional receptors (Brauner-Osborne H et al, 2007). ...
  • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
  • Taste transduction, organism-specific biosystem (from KEGG)
    Taste transduction, organism-specific biosystemFive basic tastes are recognized by humans and most other animals - bitter, sweet, sour, salty and umami. In vertebrates, taste stimuli are detected by taste receptor cells (TRCs). At least three dis...
  • Taste transduction, conserved biosystem (from KEGG)
    Taste transduction, conserved biosystemFive basic tastes are recognized by humans and most other animals - bitter, sweet, sour, salty and umami. In vertebrates, taste stimuli are detected by taste receptor cells (TRCs). At least three dis...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126635, MGC126637

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
bitter taste receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
bitter taste receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
taste receptor activity TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IC
Inferred by Curator
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
taste receptor type 2 member 5
Names
taste receptor, type 2, member 5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018980.3NP_061853.1  taste receptor type 2 member 5

    See identical proteins and their annotated locations for NP_061853.1

    Status: REVIEWED

    Source sequence(s)
    AC004979, AW881072, BC095522
    Consensus CDS
    CCDS5869.1
    UniProtKB/Swiss-Prot
    Q9NYW4
    UniProtKB/TrEMBL
    A4D1U0, Q502V5
    Related
    ENSP00000247883.4, ENST00000247883.5
    Conserved Domains (1) summary
    pfam05296
    Location:1290
    TAS2R; Taste receptor protein (TAS2R)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    141790217..141791367
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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