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Barhl1 BarH like homeobox 1 [ Mus musculus (house mouse) ]

Gene ID: 54422, updated on 26-Jun-2024

Summary

Official Symbol
Barhl1provided by MGI
Official Full Name
BarH like homeobox 1provided by MGI
Primary source
MGI:MGI:1859288
See related
Ensembl:ENSMUSG00000026805 AllianceGenome:MGI:1859288
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MBH2; Dres115
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific. Acts upstream of or within several processes, including negative regulation of neuron apoptotic process; nervous system development; and sensory perception of sound. Located in nucleus. Is expressed in several structures, including central nervous system; ear; future brain; heart; and urinary system. Orthologous to human BARHL1 (BarH like homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in whole brain E14.5 (RPKM 4.8), CNS E14 (RPKM 3.9) and 3 other tissues See more
Orthologs
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Genomic context

See Barhl1 in Genome Data Viewer
Location:
2 A3; 2 19.38 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (28797692..28807996, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (28907680..28917984, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene adenylate kinase 8 Neighboring gene high mobility group box 3 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10088 Neighboring gene general transcription factor IIIC, polypeptide 4 Neighboring gene DEAD/H box helicase 31 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene cilia and flagella associated protein 77

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
barH-like 1 homeobox protein
Names
bar-class homeodomain protein MBH2
barH-related homeobox protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164186.2NP_001157658.1  barH-like 1 homeobox protein isoform a

    See identical proteins and their annotated locations for NP_001157658.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 5 all encode the same isoform (a).
    Source sequence(s)
    AL732526
    Consensus CDS
    CCDS15849.1
    UniProtKB/Swiss-Prot
    P63157, Q9JK26
    Related
    ENSMUSP00000109480.2, ENSMUST00000113849.8
    Conserved Domains (1) summary
    pfam00046
    Location:182235
    Homeobox; Homeobox domain
  2. NM_001355434.2NP_001342363.1  barH-like 1 homeobox protein isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 5 all encode the same isoform (a).
    Source sequence(s)
    AL732526
    Consensus CDS
    CCDS15849.1
    UniProtKB/Swiss-Prot
    P63157, Q9JK26
    Related
    ENSMUSP00000109478.2, ENSMUST00000113847.3
    Conserved Domains (1) summary
    pfam00046
    Location:182235
    Homeobox; Homeobox domain
  3. NM_001355435.2NP_001342364.1  barH-like 1 homeobox protein isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AL732526
    UniProtKB/TrEMBL
    Q8BJ04
    Related
    ENSMUST00000124059.2
    Conserved Domains (1) summary
    pfam00046
    Location:3991
    Homeobox; Homeobox domain
  4. NM_001421536.1NP_001408465.1  barH-like 1 homeobox protein isoform a

    Status: VALIDATED

    Source sequence(s)
    AL732526
    UniProtKB/Swiss-Prot
    P63157, Q9JK26
  5. NM_001421537.1NP_001408466.1  barH-like 1 homeobox protein isoform c

    Status: VALIDATED

    Source sequence(s)
    AL732526
  6. NM_019446.5NP_062319.1  barH-like 1 homeobox protein isoform a

    See identical proteins and their annotated locations for NP_062319.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1, 2, 3, and 5 all encode the same isoform (a).
    Source sequence(s)
    AL732526
    Consensus CDS
    CCDS15849.1
    UniProtKB/Swiss-Prot
    P63157, Q9JK26
    Related
    ENSMUSP00000053147.3, ENSMUST00000050776.9
    Conserved Domains (1) summary
    pfam00046
    Location:182235
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    28797692..28807996 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251885.1XP_030107745.1  barH-like 1 homeobox protein isoform X1

    UniProtKB/Swiss-Prot
    P63157, Q9JK26
    Conserved Domains (1) summary
    pfam00046
    Location:182235
    Homeobox; Homeobox domain
  2. XM_030251886.1XP_030107746.1  barH-like 1 homeobox protein isoform X1

    UniProtKB/Swiss-Prot
    P63157, Q9JK26
    Conserved Domains (1) summary
    pfam00046
    Location:182235
    Homeobox; Homeobox domain
  3. XM_030251884.1XP_030107744.1  barH-like 1 homeobox protein isoform X1

    UniProtKB/Swiss-Prot
    P63157, Q9JK26
    Conserved Domains (1) summary
    pfam00046
    Location:182235
    Homeobox; Homeobox domain
  4. XM_011239138.3XP_011237440.1  barH-like 1 homeobox protein isoform X1

    See identical proteins and their annotated locations for XP_011237440.1

    UniProtKB/Swiss-Prot
    P63157, Q9JK26
    Conserved Domains (1) summary
    pfam00046
    Location:182235
    Homeobox; Homeobox domain