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Cacng4 calcium channel, voltage-dependent, gamma subunit 4 [ Mus musculus (house mouse) ]

Gene ID: 54377, updated on 27-Nov-2024

Summary

Official Symbol
Cacng4provided by MGI
Official Full Name
calcium channel, voltage-dependent, gamma subunit 4provided by MGI
Primary source
MGI:MGI:1859167
See related
Ensembl:ENSMUSG00000020723 AllianceGenome:MGI:1859167
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable calcium channel regulator activity; ionotropic glutamate receptor binding activity; and voltage-gated calcium channel activity. Involved in regulation of AMPA receptor activity and regulation of postsynaptic neurotransmitter receptor activity. Acts upstream of or within transmission of nerve impulse. Located in somatodendritic compartment. Part of AMPA glutamate receptor complex. Is active in glutamatergic synapse. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and respiratory system. Orthologous to human CACNG4 (calcium voltage-gated channel auxiliary subunit gamma 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in whole brain E14.5 (RPKM 47.6), CNS E18 (RPKM 44.4) and 7 other tissues See more
Orthologs
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Genomic context

See Cacng4 in Genome Data Viewer
Location:
11 E1; 11 70.29 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (107623183..107685532, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (107732357..107794706, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene helicase with zinc finger domain Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:107505802-107506005 Neighboring gene microRNA 6932 Neighboring gene VISTA enhancer mm1348 Neighboring gene calcium channel, voltage-dependent, gamma subunit 1 Neighboring gene predicted gene 11650 Neighboring gene calcium channel, voltage-dependent, gamma subunit 5 Neighboring gene STARR-seq mESC enhancer starr_30997 Neighboring gene STARR-seq mESC enhancer starr_30998 Neighboring gene protein kinase C, alpha Neighboring gene predicted gene 11657 Neighboring gene microRNA 7223

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (3)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium channel regulator activity ISO
Inferred from Sequence Orthology
more info
 
enables calcium channel regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ionotropic glutamate receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables ionotropic glutamate receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables voltage-gated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables voltage-gated calcium channel activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of AMPA glutamate receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of AMPA glutamate receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of AMPA glutamate receptor complex ISO
Inferred from Sequence Orthology
more info
 
part_of AMPA glutamate receptor complex ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of L-type voltage-gated calcium channel complex ISO
Inferred from Sequence Orthology
more info
 
part_of L-type voltage-gated calcium channel complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cell body IEA
Inferred from Electronic Annotation
more info
 
located_in cell body ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic density membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in postsynaptic density membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
 
located_in somatodendritic compartment IDA
Inferred from Direct Assay
more info
PubMed 
part_of voltage-gated calcium channel complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
voltage-dependent calcium channel gamma-4 subunit
Names
TARP gamma-4
neuronal voltage-gated calcium channel gamma-4 subunit
transmembrane AMPAR regulatory protein gamma-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019431.4NP_062304.1  voltage-dependent calcium channel gamma-4 subunit

    See identical proteins and their annotated locations for NP_062304.1

    Status: VALIDATED

    Source sequence(s)
    AL645853, AL645947
    Consensus CDS
    CCDS25571.1
    UniProtKB/Swiss-Prot
    Q9JJV4
    UniProtKB/TrEMBL
    A2AAU2
    Related
    ENSMUSP00000021066.4, ENSMUST00000021066.4
    Conserved Domains (1) summary
    cl21598
    Location:6202
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    107623183..107685532 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)