Prss16 protease, serine 16 (thymus) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prss16provided by MGI
Official Full Name: protease, serine 16 (thymus)provided by MGI
Primary source: MGI:MGI:1859181
See related: Ensembl:ENSMUSG00000006179 AllianceGenome:MGI:1859181
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TSSP
Summary: Predicted to enable dipeptidyl-peptidase activity. Predicted to be involved in proteolysis. Located in endosome and lysosome. Is expressed in epididymis; prostate gland; testis; and thymus. Orthologous to human PRSS16 (serine protease 16). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward thymus adult (RPKM 217.8) See more
Orthologs: human all
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Genomic context

Location:: 13 A3.1; 13 8.12 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (22186346..22193911, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (22002176..22009741, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

these results show that TSSP increases experimental autoimmune encephalomyelitis severity by limiting central tolerance to myelin oligodendrocyte glycoprotein
Title: Thymic-Specific Serine Protease Limits Central Tolerance and Exacerbates Experimental Autoimmune Encephalomyelitis.
Data indicate that T-cell receptors that react to chromogranin A (ChgA) and islet amyloid polypeptide precursor (IAPP) autoantigens were impaired when the thymic stromal cells lacked thymus-specific serine protease (TSSP).
Title: The T Cell Repertoire-Diversifying Enzyme TSSP Contributes to Thymic Selection of Diabetogenic CD4 T Cell Specificities Reactive to ChgA and IAPP Autoantigens.
our data demonstrate that antitumoral immune surveillance requires thymic TSSP-driven production of CD4(+) T cells contributing to inflammatory balance.
Title: The thymus-specific serine protease TSSP/PRSS16 is crucial for the antitumoral role of CD4(+) T cells.
The differential thymic expression of 4,500 mRNAs of wild-type (WT) C57BL/6 mice with their respective Prss16-knockout (KO) mutants by using microarrays, was analyzed.
Title: Transcription profiling of Prss16 (Tssp) can be used to find additional peptidase genes that are candidates for self-peptide generation in the thymus.
Tssp is a critical regulator of diabetes development through the selection of the autoreactive CD4 T cell repertoire
Title: Thymus-specific serine protease controls autoreactive CD4 T cell development and autoimmune diabetes in mice.
suggesting that TSSP is necessary for the intrathymic development of cells expressing these T cell receptors
Title: Thymus-specific serine protease contributes to the diversification of the functional endogenous CD4 T cell receptor repertoire.
Prss16 is involved in the positive selection of some CD4(+) T lymphocytes and likely constitutes the first serine protease to play a function in the intrathymic presentation of self-peptides bound to MHC class II complexes.
Title: Thymus-specific serine protease regulates positive selection of a subset of CD4+ thymocytes.
role of Prss16 in T-cell development and susceptibility to autoimmunity in the mouse
Title: Expression, genomic structure and mapping of the thymus specific protease prss16: a candidate gene for insulin dependent diabetes mellitus susceptibility.
Data suggest that Prss16 is not required for quantitatively normal T-cell development.
Title: Prss16 is not required for T-cell development.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (2)

General gene information

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Homology

Homologs of the Prss16 gene: The Prss16 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, zebrafish, A.thaliana, rice, and frog.
Orthologs from Annotation Pipeline: 352 organisms have orthologs with human gene Prss16
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables dipeptidyl-peptidase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	ISO Inferred from Sequence Orthology more info
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed
located_in lysosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: thymus-specific serine protease

Names: serine protease 16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.