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CYTL1 cytokine like 1 [ Homo sapiens (human) ]

Gene ID: 54360, updated on 8-Jul-2021

Summary

Official Symbol
CYTL1provided by HGNC
Official Full Name
cytokine like 1provided by HGNC
Primary source
HGNC:HGNC:24435
See related
Ensembl:ENSG00000170891 MIM:607930
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C17; C4orf4
Summary
C17 is a cytokine-like protein specifically expressed in bone marrow and cord blood mononuclear cells that bear the CD34 (MIM 142230) surface marker (Liu et al., 2000 [PubMed 10857752]).[supplied by OMIM, Mar 2008]
Expression
Biased expression in placenta (RPKM 17.2), urinary bladder (RPKM 5.8) and 11 other tissues See more
Orthologs
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Genomic context

See CYTL1 in Genome Data Viewer
Location:
4p16.2
Exon count:
5
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (5014586..5019470, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (5016313..5021185, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928306 Neighboring gene uncharacterized LOC107986218 Neighboring gene RN7SK pseudogene 113 Neighboring gene uncharacterized LOC107986256 Neighboring gene serine/threonine kinase 32B Neighboring gene uncharacterized LOC105374362

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables signaling receptor binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in cartilage homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in chondrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in chondroitin sulfate proteoglycan biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in inner ear development IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular space TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
cytokine-like protein 1
Names
cytokine-like protein C17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018659.3NP_061129.1  cytokine-like protein 1 precursor

    See identical proteins and their annotated locations for NP_061129.1

    Status: VALIDATED

    Source sequence(s)
    AC108139
    Consensus CDS
    CCDS3379.1
    UniProtKB/Swiss-Prot
    Q9NRR1
    Related
    ENSP00000303550.4, ENST00000307746.9
    Conserved Domains (1) summary
    pfam15153
    Location:21130
    CYTL1; Cytokine-like protein 1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    5014586..5019470 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008299.1XP_016863788.1  cytokine-like protein 1 isoform X1

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