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POLR2G RNA polymerase II subunit G [ Homo sapiens (human) ]

Gene ID: 5436, updated on 6-Jan-2019

Summary

Official Symbol
POLR2Gprovided by HGNC
Official Full Name
RNA polymerase II subunit Gprovided by HGNC
Primary source
HGNC:HGNC:9194
See related
Ensembl:ENSG00000168002 MIM:602013
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RPB7; RPB19; hRPB19; hsRPB7
Summary
This gene encodes the seventh largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The protein functions in transcription initiation, and is also thought to help stabilize transcribing polyermase molecules during elongation. [provided by RefSeq, Jan 2009]
Expression
Ubiquitous expression in lymph node (RPKM 35.1), brain (RPKM 26.4) and 25 other tissues See more
Orthologs

Genomic context

See POLR2G in Genome Data Viewer
Location:
11q12.3
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (62761539..62766715)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (62529011..62534187)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 9C Neighboring gene zinc finger and BTB domain containing 3 Neighboring gene TATA-box binding protein associated factor 6 like Neighboring gene transmembrane protein 179B Neighboring gene microRNA 6748

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The transcription factors and kinases c-Jun, JNK, MEK, p38 MAPK, STAT-3, JAK-1, TFII D, TFII F, eIF-4E, and RNA polymerase II are induced by HIV-1 gp120 PubMed
Tat tat The interaction of Tip110 with HIV-1 Tat leads to a higher efficiency of elongation for RNAPII complexes formed on the LTR promoter PubMed
tat Expression of both Tip110 and Tat enhances phosphorylation of RNAPII at both serine 2 and serine 5, which account for Tip110 function in transcription activation PubMed
tat The interaction of Tip110 with HIV-1 Tat and the RNAPII C-terminal domain leads to the recruitment of increased CDK9/CycT1 to the transcription complex PubMed
tat HIV-1 Tat complexes with RNA polymerase II and cellular transcription factors as part of the HIV-1 transcription preinitiation and elongation complexes and stimulates RNA polymerase II processivity by inducing the phosphorylation of its C-terminal Domain PubMed
tat A small molecule compound C3 inhibits HIV-1 replication by suppressing HIV-1 Tat-mediated HIV-1 LTR-driven gene expression and phosphorylation of RNAPII through inhibition of Tat binding to CycT1 PubMed
tat JQ1, a small molecule inhibitor of Brd4, directly dissociates Brd4 from HIV-1 promoter and promotes subsequently HIV-1 Tat binding to HIV-1 promoter, resulting in increased phosphorylation of RNA polymerase II and viral transcription PubMed
tat HIV-1 Tat 41/44 peptide TAALS from the core domain of Tat inhibits Tat-mediated HIV-1 gene expression and replication by binding the Cdk2/Cyclin E complex and inhibiting the phosphorylation of serine 5 of RNAPII PubMed
Vpr vpr HIV-1 Vpr interacts with basal transcription complexes such as P-TEFb, TFIIH, TFIID (TBP) and TFIIB which activate RNA polymerase II gene transcription PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC138367, MGC138369

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to DNA-directed 5'-3' RNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
single-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translation initiation factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
7-methylguanosine mRNA capping TAS
Traceable Author Statement
more info
 
RNA metabolic process TAS
Traceable Author Statement
more info
 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
fibroblast growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
mRNA splicing, via spliceosome TAS
Traceable Author Statement
more info
 
nuclear-transcribed mRNA catabolic process, exonucleolytic IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of nuclear-transcribed mRNA poly(A) tail shortening IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of gene silencing by miRNA TAS
Traceable Author Statement
more info
 
snRNA transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 
transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 
transcription elongation from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
transcription initiation from RNA polymerase II promoter IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription initiation from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
transcription-coupled nucleotide-excision repair TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
P-body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II, core complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II, core complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
DNA-directed RNA polymerase II subunit RPB7
Names
DNA directed RNA polymerase II 19 kda polypeptide
DNA-directed RNA polymerase II 19 kDa polypeptide
DNA-directed RNA polymerase II subunit G
RNA polymerase II 19 kDa subunit
RNA polymerase II seventh subunit
RNA polymerase II subunit B7
polymerase (RNA) II (DNA directed) polypeptide G
polymerase (RNA) II subunit G
NP_002687.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002696.3NP_002687.1  DNA-directed RNA polymerase II subunit RPB7

    See identical proteins and their annotated locations for NP_002687.1

    Status: REVIEWED

    Source sequence(s)
    AW016747, BC112162, BG530809
    Consensus CDS
    CCDS31585.1
    UniProtKB/Swiss-Prot
    P62487
    Related
    ENSP00000301788.7, ENST00000301788.11
    Conserved Domains (1) summary
    cl04309
    Location:1169
    RNAP_Rpb7_N_like; RNAP_Rpb7_N_like: This conserved domain represents the N-terminal ribonucleoprotein (RNP) domain of the Rpb7 subunit of eukaryotic RNA polymerase (RNAP) II and its homologs, Rpa43 of eukaryotic RNAP I, Rpc25 of eukaryotic RNAP III, and RpoE (subunit E) ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    62761539..62766715
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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