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Atf7ip activating transcription factor 7 interacting protein [ Mus musculus (house mouse) ]

Gene ID: 54343, updated on 21-Apr-2024

Summary

Official Symbol
Atf7ipprovided by MGI
Official Full Name
activating transcription factor 7 interacting proteinprovided by MGI
Primary source
MGI:MGI:1858965
See related
Ensembl:ENSMUSG00000030213 AllianceGenome:MGI:1858965
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AM; Mcaf1; 2610204M12Rik; 5830415B17Rik
Summary
Enables ATP hydrolysis activity and transcription corepressor activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; male reproductive gland or organ; and sensory organ. Orthologous to human ATF7IP (activating transcription factor 7 interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 11.1), whole brain E14.5 (RPKM 7.8) and 28 other tissues See more
Orthologs
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Genomic context

Location:
6; 6 G1
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (136495787..136587848)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (136518789..136610850)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:136440301-136440484 Neighboring gene ribosomal protein L36A, pseudogene 3 Neighboring gene STARR-seq mESC enhancer starr_17596 Neighboring gene predicted gene, 44140 Neighboring gene coenzyme Q2 homolog, prenyltransferase pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E691 Neighboring gene STARR-positive B cell enhancer ABC_E9106 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:136480481-136480679 Neighboring gene STARR-seq mESC enhancer starr_17599 Neighboring gene STARR-positive B cell enhancer ABC_E9282 Neighboring gene STARR-positive B cell enhancer ABC_E1715 Neighboring gene STARR-positive B cell enhancer ABC_E10415 Neighboring gene STARR-seq mESC enhancer starr_17605 Neighboring gene phospholipase B domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E4875 Neighboring gene predicted gene, 40409 Neighboring gene protein S100-A10 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription coregulator activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
activating transcription factor 7-interacting protein 1
Names
ATFa-associated Modulator
MBD1-containing chromatin-associated factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001388194.1NP_001375123.1  activating transcription factor 7-interacting protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124779, AC134474
    Conserved Domains (5) summary
    PHA03247
    Location:8691213
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:83362
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5271
    Location:290626
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    pfam16788
    Location:601812
    ATF7IP_BD; ATF-interacting protein binding domain
    pfam16794
    Location:11991299
    fn3_4; Fibronectin-III type domain
  2. NM_001388195.1NP_001375124.1  activating transcription factor 7-interacting protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC124779, AC134474
    Conserved Domains (5) summary
    PHA03247
    Location:8681212
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:83362
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5271
    Location:290623
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    pfam16788
    Location:598811
    ATF7IP_BD; ATF-interacting protein binding domain
    pfam16794
    Location:11981298
    fn3_4; Fibronectin-III type domain
  3. NM_001388196.1NP_001375125.1  activating transcription factor 7-interacting protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC124779, AC134474
    Conserved Domains (5) summary
    PHA03247
    Location:8661208
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:83362
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5271
    Location:290623
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    pfam16788
    Location:598809
    ATF7IP_BD; ATF-interacting protein binding domain
    pfam16794
    Location:11941294
    fn3_4; Fibronectin-III type domain
  4. NM_001388197.1NP_001375126.1  activating transcription factor 7-interacting protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC124779, AC134474
    Conserved Domains (3) summary
    PHA03247
    Location:271615
    PHA03247; large tegument protein UL36; Provisional
    pfam16788
    Location:3214
    ATF7IP_BD; ATF-interacting protein binding domain
    pfam16794
    Location:601701
    fn3_4; Fibronectin-III type domain
  5. NM_019426.3NP_062299.2  activating transcription factor 7-interacting protein 1 isoform 3

    See identical proteins and their annotated locations for NP_062299.2

    Status: VALIDATED

    Source sequence(s)
    AC124779, AC134474
    Consensus CDS
    CCDS20651.1
    UniProtKB/Swiss-Prot
    Q3TJ86, Q3TZW1, Q3UVK5, Q3UYZ7, Q7TT18, Q80ZK7, Q8C4A1, Q9JK31
    Related
    ENSMUSP00000032335.7, ENSMUST00000032335.13
    Conserved Domains (5) summary
    PHA03247
    Location:8661210
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:83362
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5271
    Location:290623
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    pfam16788
    Location:598809
    ATF7IP_BD; ATF-interacting protein binding domain
    pfam16794
    Location:11961296
    fn3_4; Fibronectin-III type domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    136495787..136587848
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036166296.1XP_036022189.1  activating transcription factor 7-interacting protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q3TJ86, Q3TZW1, Q3UVK5, Q3UYZ7, Q7TT18, Q80ZK7, Q8C4A1, Q9JK31
    Conserved Domains (5) summary
    PHA03247
    Location:8661210
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:83362
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5271
    Location:290623
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    pfam16788
    Location:598809
    ATF7IP_BD; ATF-interacting protein binding domain
    pfam16794
    Location:11961296
    fn3_4; Fibronectin-III type domain
  2. XM_036166295.1XP_036022188.1  activating transcription factor 7-interacting protein 1 isoform X1

    Conserved Domains (5) summary
    PHA03247
    Location:8691213
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:83362
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5271
    Location:290626
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    pfam16788
    Location:601812
    ATF7IP_BD; ATF-interacting protein binding domain
    pfam16794
    Location:11991299
    fn3_4; Fibronectin-III type domain
  3. XM_017321681.3XP_017177170.1  activating transcription factor 7-interacting protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q3TJ86, Q3TZW1, Q3UVK5, Q3UYZ7, Q7TT18, Q80ZK7, Q8C4A1, Q9JK31
    Conserved Domains (5) summary
    PHA03247
    Location:8661210
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:83362
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5271
    Location:290623
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    pfam16788
    Location:598809
    ATF7IP_BD; ATF-interacting protein binding domain
    pfam16794
    Location:11961296
    fn3_4; Fibronectin-III type domain
  4. XM_006506390.5XP_006506453.1  activating transcription factor 7-interacting protein 1 isoform X3

    Conserved Domains (5) summary
    PHA03247
    Location:8771221
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:91370
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5271
    Location:298634
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    pfam16788
    Location:609820
    ATF7IP_BD; ATF-interacting protein binding domain
    pfam16794
    Location:12071307
    fn3_4; Fibronectin-III type domain
  5. XM_030255502.2XP_030111362.1  activating transcription factor 7-interacting protein 1 isoform X4

    Conserved Domains (5) summary
    PHA03247
    Location:8741218
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:91370
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5271
    Location:298631
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    pfam16788
    Location:606817
    ATF7IP_BD; ATF-interacting protein binding domain
    pfam16794
    Location:12041304
    fn3_4; Fibronectin-III type domain
  6. XM_006506388.5XP_006506451.2  activating transcription factor 7-interacting protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006506451.2

    Conserved Domains (5) summary
    PHA03247
    Location:8691213
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:83362
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5271
    Location:290626
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    pfam16788
    Location:601812
    ATF7IP_BD; ATF-interacting protein binding domain
    pfam16794
    Location:11991299
    fn3_4; Fibronectin-III type domain
  7. XM_006506389.5XP_006506452.2  activating transcription factor 7-interacting protein 1 isoform X2

    See identical proteins and their annotated locations for XP_006506452.2

    UniProtKB/Swiss-Prot
    Q3TJ86, Q3TZW1, Q3UVK5, Q3UYZ7, Q7TT18, Q80ZK7, Q8C4A1, Q9JK31
    Conserved Domains (5) summary
    PHA03247
    Location:8661210
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:83362
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5271
    Location:290623
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    pfam16788
    Location:598809
    ATF7IP_BD; ATF-interacting protein binding domain
    pfam16794
    Location:11961296
    fn3_4; Fibronectin-III type domain
  8. XM_036166294.1XP_036022187.1  activating transcription factor 7-interacting protein 1 isoform X1

    Conserved Domains (5) summary
    PHA03247
    Location:8691213
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:83362
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5271
    Location:290626
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    pfam16788
    Location:601812
    ATF7IP_BD; ATF-interacting protein binding domain
    pfam16794
    Location:11991299
    fn3_4; Fibronectin-III type domain
  9. XM_030255503.2XP_030111363.1  activating transcription factor 7-interacting protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q3TJ86, Q3TZW1, Q3UVK5, Q3UYZ7, Q7TT18, Q80ZK7, Q8C4A1, Q9JK31
    Conserved Domains (5) summary
    PHA03247
    Location:8661210
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:83362
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5271
    Location:290623
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    pfam16788
    Location:598809
    ATF7IP_BD; ATF-interacting protein binding domain
    pfam16794
    Location:11961296
    fn3_4; Fibronectin-III type domain
  10. XM_006506392.3XP_006506455.1  activating transcription factor 7-interacting protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006506455.1

    Conserved Domains (5) summary
    PHA03247
    Location:8691213
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:83362
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5271
    Location:290626
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    pfam16788
    Location:601812
    ATF7IP_BD; ATF-interacting protein binding domain
    pfam16794
    Location:11991299
    fn3_4; Fibronectin-III type domain

RNA

  1. XR_004942987.1 RNA Sequence

  2. XR_004942986.1 RNA Sequence