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POLR2D RNA polymerase II subunit D [ Homo sapiens (human) ]

Gene ID: 5433, updated on 3-Jun-2018
Official Symbol
POLR2Dprovided by HGNC
Official Full Name
RNA polymerase II subunit Dprovided by HGNC
Primary source
HGNC:HGNC:9191
See related
Ensembl:ENSG00000144231 MIM:606017; Vega:OTTHUMG00000131531
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RBP4; RPB16; HSRBP4; HSRPB4
Summary
This gene encodes the fourth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. In yeast, this polymerase subunit is associated with the polymerase under suboptimal growth conditions and may have a stress protective role. A sequence for a ribosomal pseudogene is contained within the 3' untranslated region of the transcript from this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 27.2), lymph node (RPKM 9.2) and 25 other tissues See more
Orthologs
See POLR2D in Genome Data Viewer
Location:
2q14.3
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (127846266..127858155, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (128603840..128615729, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ZFP91 zinc finger protein pseudogene Neighboring gene RNA, U6 small nuclear 395, pseudogene Neighboring gene ribosomal protein S26 pseudogene 19 Neighboring gene uncharacterized LOC107985803 Neighboring gene AMMECR1 like Neighboring gene uncharacterized LOC107985944

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The transcription factors and kinases c-Jun, JNK, MEK, p38 MAPK, STAT-3, JAK-1, TFII D, TFII F, eIF-4E, and RNA polymerase II are induced by HIV-1 gp120 PubMed
Tat tat The interaction of Tip110 with HIV-1 Tat leads to a higher efficiency of elongation for RNAPII complexes formed on the LTR promoter PubMed
tat Expression of both Tip110 and Tat enhances phosphorylation of RNAPII at both serine 2 and serine 5, which account for Tip110 function in transcription activation PubMed
tat The interaction of Tip110 with HIV-1 Tat and the RNAPII C-terminal domain leads to the recruitment of increased CDK9/CycT1 to the transcription complex PubMed
tat HIV-1 Tat complexes with RNA polymerase II and cellular transcription factors as part of the HIV-1 transcription preinitiation and elongation complexes and stimulates RNA polymerase II processivity by inducing the phosphorylation of its C-terminal Domain PubMed
tat A small molecule compound C3 inhibits HIV-1 replication by suppressing HIV-1 Tat-mediated HIV-1 LTR-driven gene expression and phosphorylation of RNAPII through inhibition of Tat binding to CycT1 PubMed
tat JQ1, a small molecule inhibitor of Brd4, directly dissociates Brd4 from HIV-1 promoter and promotes subsequently HIV-1 Tat binding to HIV-1 promoter, resulting in increased phosphorylation of RNA polymerase II and viral transcription PubMed
tat HIV-1 Tat 41/44 peptide TAALS from the core domain of Tat inhibits Tat-mediated HIV-1 gene expression and replication by binding the Cdk2/Cyclin E complex and inhibiting the phosphorylation of serine 5 of RNAPII PubMed
Vpr vpr HIV-1 Vpr interacts with basal transcription complexes such as P-TEFb, TFIIH, TFIID (TBP) and TFIIB which activate RNA polymerase II gene transcription PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
CONTRIBUTES_TO DNA-directed 5'-3' RNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-directed 5'-3' RNA polymerase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
CONTRIBUTES_TO single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
CONTRIBUTES_TO single-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translation initiation factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
7-methylguanosine mRNA capping TAS
Traceable Author Statement
more info
 
RNA metabolic process TAS
Traceable Author Statement
more info
 
fibroblast growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
mRNA export from nucleus in response to heat stress IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA splicing, via spliceosome TAS
Traceable Author Statement
more info
 
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of gene silencing by miRNA TAS
Traceable Author Statement
more info
 
snRNA transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 
transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 
transcription elongation from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
transcription initiation from RNA polymerase II promoter IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription initiation from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
transcription-coupled nucleotide-excision repair TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
DNA-directed RNA polymerase II, core complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-directed RNA polymerase II, core complex IDA
Inferred from Direct Assay
more info
PubMed 
P-body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nuclear speck IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
DNA-directed RNA polymerase II subunit RPB4
Names
DNA-directed RNA polymerase II 16 kDa polypeptide
DNA-directed RNA polymerase II subunit D
RNA polymerase II 16 kDa subunit
RNA polymerase II subunit B4
RNA polymerase II subunit hsRBP4
polymerase (RNA) II (DNA directed) polypeptide D
polymerase (RNA) II subunit D
NP_004796.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004805.3NP_004796.1  DNA-directed RNA polymerase II subunit RPB4

    See identical proteins and their annotated locations for NP_004796.1

    Status: REVIEWED

    Source sequence(s)
    AA775787, AC006011, BC093795
    Consensus CDS
    CCDS2151.1
    UniProtKB/Swiss-Prot
    O15514
    UniProtKB/TrEMBL
    A0A024RAJ4
    Related
    ENSP00000272645.3, OTTHUMP00000162266, ENST00000272645.8, OTTHUMT00000254388
    Conserved Domains (1) summary
    smart00657
    Location:24141
    RPOL4c; DNA-directed RNA-polymerase II subunit

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    127846266..127858155 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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